A comparison of the oxytocin and vasopressin responses to the 5-HT(1A) agonist and potential anxiolytic drug alnespirone (S-20499)

Pharmacology Biochemistry and Behavior

Volumn 60, Issue 3, 1998, Pages 677-683

  Van De Kar, Louis D ^a   Levy, Andrew D ^a   Li, Qian ^a   Brownfield, Mark S ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

5 HT(1A) antagonist; Dose response; Hormone; Hypothalamus; Neuroendocrine; Paraventricular nucleus; Receptor; Secretion; Serotonin; Time course

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALNESPIRONE; ANXIOLYTIC AGENT; BUSPIRONE; IPSAPIRONE; NEUROHORMONE; OXYTOCIN; PINDOLOL; SEROTONIN AGONIST; SPIPERONE; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL EXPERIMENT; ARTICLE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG SCREENING; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; OXYTOCIN BLOOD LEVEL; OXYTOCIN RELEASE; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; THALAMUS MIDLINE NUCLEUS; VASOPRESSIN BLOOD LEVEL; VASOPRESSIN RELEASE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-ANXIETY AGENTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; OXYTOCIN; PINDOLOL; RATS; SEROTONIN AGONISTS; SPIPERONE; SPIRO COMPOUNDS; VASOPRESSINS;

EID: 0031827433     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(98)00025-2     Document Type: Article

References (50)

1. 2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behav. Brain Res. 73:277-280; 1995.
2. 1C receptors induce oxytocin release in the male rat. Brain Res. 611:330-332; 1993.
3. 2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. Eur. J. Pharmacol. 229:9-14; 1992.
4. 2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses. Endocrinology 134:1127-1131; 1994.
5. Bagdy, G.; Sved, A. F.; Murphy, D. L.; Szemeredi, K.: Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur. J. Pharmacol. 210:285-289; 1992.
6. 1A receptors: Variations in intrinsic activity studied in transfected HeLa cells. Naunyn Schmiedebergs Arch. Pharmacol. 345:257-263; 1992.
7. Boess, F. G.; Martin, I. L.: Molecular biology of 5-HT receptors. Neuropharmacology 33:275-317; 1994.
8. Bourque, C. W.; Oliet, S. H.; Richard, D.: Osmoreceptors, osmoreception, and osmoregulation. Front. Neuroendocrinol. 15:231-274; 1994.
9. Brownfield, M. S.; Greathouse, J.; Lorens, S. A.; Armstrong, J.; Urban, J. H.; Van de Kar, L. D.: Neuropharmacological characterization of serotoninergic stimulation of vasopressin secretion in conscious rats. Neuroendocrinology 47:277-283; 1988.
10. 1A receptor ligands on a safety signal withdrawal procedure of conflict in the rat. Pharmacol. Biochem. Behav. 48:281-289; 1994.
11. 1A full agonist, in the elevated plus-maze and social interaction tests. Drug Dev. Res. 32:183-190; 1994.
12. 1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 268:441-447; 1994.
13. Falke, N.: Modulation of oxytocin and vasopressin release at the level of the neurohypophysis. Prog. Neurobiol. 36:465-484; 1991.
14. Faull, C. M.; Charlton, J. A.; Phillips, E.; Thornton, S.; Butler, T.; Baylis, P. H.: The effect of modulation of central serotonin neurotransmission on osmoregulated vasopressin release in rats. Ann. NY Acad. Sci. 689:484-488; 1993.
15. 1A agonists in drug-naive and in benzodiazepine-experienced rats. Behav. Pharmacol. 5:99-102; 1994.
16. Gainer, H.; Wray, S.: Oxytocin and vasopressin: From genes to peptides. Ann. NY Acad. Sci. 652:14-28; 1992.
17. 1A receptor. Biochemistry 33:4283-4290; 1994.
18. 1A receptor agonists and antagonists: A comparison to adrenergic and dopaminergic neurons in rats. J. Pharmacol. Exp. Ther. 273:1032-1046; 1995.
19. 1A agonist anxiolytic S-20499. Behav. Pharmacol. 5:131-140; 1994.
20. Griebel, G.: 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research. Pharmacol. Ther. 65:319-395; 1995.
21. 1A agonist S20244, and its enantiomers in mice. Neuroreport 3:84-86; 1992.
22. 1A receptor: A site-directed mutation study. FEBS Lett. 312:259-262; 1992.
23. Hoyer, D.; Clarke, D. E.; Fozard, J. R.; Hartig, P. R.; Martin, G. R.; Mylecharane, E. J.; Saxena, P. R.; Humphrey, P. P. A., VII.: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:157-204; 1994.
24. Hoyer, D.; Schoeffter, P.: 5-HT receptors: Subtypes and second messengers. J. Receptor Res. 11:197-214; 1991.
25. Iovino, M.; Steardo, L.: Effect of substances influencing brain serotonergic transmission on plasma vasopressin levels in the rat. Eur. J. Pharmacol. 113:99-103; 1985.
26. Kadekaro, M.; Summy-Long, J. Y.; Harris, J. S.; Terrell, M. L.; Freeman, S.; Eisenberg, H. M.: Cerebral metabolic and vasopressin and oxytocin responses during osmotic stimulation in conscious rats. J. Neuroendocrinol. 4:217-222; 1992.
27. Kawano, S.; Osaka, T.; Kannan, H.; Yamashita, H.: Excitation of hypothalamic paraventricular neurons by stimulation of the raphe nuclei. Brain Res. Bull. 28:573-579; 1992.
28. 1A receptors. J. Pharmacol. Exp. Ther. 264:863-872; 1993.
29. 1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. Eur. J. Pharmacol. 249:25-35; 1993.
30. 1B receptors. Eur. J. Pharmacol. Mol. Pharmacol. 244:77-87; 1993.
31. Levy, A. D.; Li, Q.; Gustafson, M.; Van de Kar, L. D.: Neuroendocrine profile of the potential anxiolytic drug S-20499. Eur. J. Pharmacol. 274:141-149; 1995.
32. 1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats. Biol. Psychiatry 36:300-308; 1994.
33. 1A agonist 8-OH-DPAT in male rats. Brain Res. 630:148-156; 1993.
34. 1A agonist. J. Pharmacol. Exp. Ther. 279:1035-1042; 1996.
35. Lukic, D.; Haldar, J.: Isotonic and hypertonic saline act as stressful stimuli for oxytocinergic system of the pituitary, hypothalamus and spinal cord. Life Sci. 53:579-584; 1993.
36. 1A neurons of the dorsal raphe. Gen. Pharmacol. 25:675-683; 1994.
37. Montes, R.; Johnson, A. K.: Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin. Am. J. Physiol. 259:R1267-R1273; 1990.
38. Onaka, T.; Palmer, J. R.; Yagi, K.: Norepinephrine depletion impairs neuroendocrine responses to fear but not novel environmental stimuli in the rat. Brain Res. 713:261-268; 1996.
39. Pergola, P. E.; Sved, A. F.; Voogt, J. L.; Alper, R. H.: Effect of serotonin on vasopressin release: A comparison to corticosterone, prolactin and renin. Neuroendocrinology 57:550-558; 1993.
40. 1A agonist properties: S 20499 (+). Drug Dev. Res. 27:389-402; 1992.
41. 1A receptors: In vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology 15:349-360; 1996.
42. Saydoff, J. A.; Carnes, M.; Brownfield, M. S.: The role of serotonergic neurons in intravenous hypertonic saline-induced secretion of vasopressin, oxytocin, and ACTH. Brain Res. Bull. 32:567-572; 1993.
43. Saydoff, J. A.; Rittenhouse, P. A.; Carnes, M.; Armstrong, J.; Van de Kar, L. D.; Brownfield, M. S.: Neuroendocrine and cardiovascular effects of serotonin: Selective role of brain angiotensin on vasopressin. Am. J. Physiol. 270:E513-E521; 1996.
44. Saydoff, J. A.; Rittenhouse, P. A.; Van de Kar, L. D.; Brownfield, M. S.: Enhanced serotonergic transmission stimulates oxytocin secretion in conscious male rats. J. Pharmacol. Exp. Ther. 257:95-99; 1991.
45. Steel, R. G. D.; Torrie, J. H.: Principles and procedures of statistics with special reference to the biological sciences. New York: McGraw-Hill; 1960.
46. Van de Kar, L. D.; Brownfield, M. S.: Serotonergic neurons and neuroendocrine function. NIPS 8:202-207; 1993.
47. Van Wijngaarden, I.; Tulp, M. T. M.; Soudijn, W.: The concept of selectivity in 5-HT receptor research. Eur. J. Pharmacol. 188:301-312; 1990.
48. Vicentic, A.; Li, Q.; Battaglia, G.; Van de Kar, L. D.: WAY-100635 inhibits 8-OH-DPAT stimulated oxytocin, ACTH, and corticosterone, but not prolactin secretion. Eur. J. Pharmacol. (in press).
49. Yagi, K.; Onaka, T.: Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear- and anxiety-producing stimuli in the rat. Neurosci. Res. 24:151-158; 1996.
50. Zifa, E.; Fillion, G.: 5-Hydroxytryptamine receptors. Pharmacol. Rev. 44:401-458; 1992.