Vascular deprivation-induced necrosis of the femoral head of the rat. An experimental model of avascular osteonecrosis in the skeletally immature individual or Legg-Perthes disease

International Journal of Experimental Pathology

Volumn 79, Issue 3, 1998, Pages 173-181

  Norman, D ^a   Reis, D ^a   Zinman, C ^a   Misselevich, I ^a   Boss, J H ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

Bone remodeling; Degeneration of the articular cartilage; Experimental model; Femoral head; Osteonecrosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVASCULAR NECROSIS; BONE BLOOD FLOW; BONE NECROSIS; BONE REMODELING; FEMALE; FEMUR HEAD; NONHUMAN; PATHOPHYSIOLOGY; PERTHES DISEASE; PRIORITY JOURNAL; RAT;

ANIMALS; BONE REMODELING; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; FEMALE; FEMUR HEAD; FEMUR HEAD NECROSIS; LEGG-PERTHES DISEASE; RATS; REGIONAL BLOOD FLOW; TIME FACTORS;

EID: 0031826880     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1998.00063.x     Document Type: Article

References (31)

1. ASPENBERG P., WANG J.S., JONSSON K. & HAGERT C.G. (1994) Experimental osteonecrosis of the lunate. Revascularization may cause collapse. J. Hand Surg. 19B, 565-569.
2. BASSETT L.W., MIRRA J.W., CRACCHIOLO A. & GOLD R.H. (1987) Ischemic necrosis of the femoral head: Correlation of magnetic resonance imaging and histologic sections. Clin. Orthop. 223, 181-187.
3. BUCKWALTER J.A., GLIMCHER M.J., COOPER R.R. & RECKER R. (1995) Bone biology. Part I: Structure, blood supply, cells, matrix, and mineralization. J. Bone Joint Surg. 77A, 1256-1275.
4. BULLOUGH P.G., KAMBOLIS C.P., MARCOVE R.C. & JAFFE H.L. (1965) Bone infarctions not associated with caisson disease. J. Bone Joint Surg. 47A, 477-491.
5. CATTERAL A., PRINGLE J., BYERS P.D., FULFORD G.E., KEMP H.B.S., DOLMAN C.L., BELL H.M., MCKIBBIN B., RALIS Z., JENSEN O.M., LAURITZEN J., PONSETI J.V. & OGDEN J. (1982) A review of the morphology of Perthes' disease. J. Bone Joint Surg. 64B, 269-275.
6. CATTO M. (1965) A histological study of avascular necrosis of the femoral head after transcervical fracture. J. Bone Joint Surg. 47B, 749-776.
7. FROST H.M. (1997) Defining osteopenias and osteoporoses: Another view (with insights from a new paradigm). Bone 20, 385-391.
8. GAGE A.A., GREENE G.W. JR, NEIDERS M.E. & EMMINGS F.G. (1966) Freezing bone without excision: An experimental study of bone cell destruction and manner of regrowth in dog. J. Am. Med. Ass. 196, 770-774.
9. GARGENIERS J., FAVENESI J., HUISKES R., SLOOFF T. & KUBAT K. (1988) Behavior of normal, avascular and revascularizing cancellous bone in the femoral head. Acta Orthop. Scand. Supplement 227, 20.
10. GLIMCHER M.J. & KENZORA J.E. (1979a) The biology of osteonecrosis of the human femoral head and its clinical implication. I. Tissue Biology. Clin. Orthop. 138, 284-309.
11. GLIMCHER M.J. & KENZORA J.E. (1979b) The biology of osteonecrosis of the human femoral head and its clinical implication. II. The pathological changes in the femoral head as an organ and in the hip joint. Clin. Orthop. 139, 283-312.
12. GLIMCHER M.J. & KENZORA J.E. (1979c) The biology of osteonecrosis of the human femoral head and its clinical implication. III. Discussion of the etiology and the genesis of the pathological sequelae, comments on treatment. Clin. Orthop. 140, 273-312.
13. GONZALES DEL PINO J., KNAPP K., GOMEZ CASTRESANA F., BENITO M., GUTIERREZ DE LA CAMARA A., CANOSA R. & DE MIGUEL E. (1988) Vascular medullary patency in free vascularised bone graft: CT scan experimental study. J. Reconstr. Microsurg. 4, 271-276.
14. JONES J.P. JR (1991) Etiology and pathogenesis of osteonecrosis. Sem. Arthroplasty 2, 160-168.
15. JONES L.C. & HUNGERFORD D.S. (1984) Models of ischaemic necrosis of bone. In Bone Circulation, Eds. J. Arlet, R. P. Ficat & D. S. Hungerford. Baltimore: Williams and Wilkins. pp. 30-34.
16. KAHLSTROM S.C. & PHEMISTER D.B. (1946) Bone infarcts. Case report with autopsy findings. Am. J. Path. 22, 947-963.
17. KALLIO P.E., MAH E.T., FOSTER B.K., PATERSON D.C. & LEQUESNE G.W.J. (1995) Slipped capital femoral epiphysis. Incidence and clinical assessment of physeal instability. J. Bone Joint Surg. 77B, 752-755.
18. KISTLER G.H. (1934) Sequences of experimental infarction of the femur in rabbits. Arch. Surg. 29, 589-611.
19. MALIZOS K.M., QUARLES L.D., SEABER A.V., RIZK W.S. & URBANIAK J.R. (1993) An experimental canine model of osteonecrosis: Characterization of the repair process. J. Orthop Res. 11, 350-357.
20. MATSUI M., OHZONO K., NAKAMURA N., SAGANO N., MASUHARA K., NAKATA K., TAKAOKA K., ONO K. & OCHI T. (1995) Immune reaction to heterologous serum-induced reaction causes osteonecrosis in rabbits. Virchows Arch. path. Anat. 427, 205-211.
21. MEDGYESI S. (1971) Bone growth in the femoral head following pedicled bone grafting: An experimental study. Acta Orthop. Scand. 42, 82-93.
22. MONT M. & HUNGERFORD D. (1995) Non-traumatic avascular necrosis of the femoral head. J. Bone Joint Surg. 77A, 459-474.
23. NELKEN D., GABRIEL M. & BOSS J.H. (1966) Modification of homograft rejection pattern in sperm-treated rabbits. Lab. Invest. 15, 1263-1268.
24. PLENK H. JR, HOFMANN S., ESCHBERGER J., GSTETTNER M., KRAMER J., SCHNEIDER J. & ENGEL A. (1997) Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin. Orthop. 334, 73-84.
25. ROACH H.I., SHEARER J.R. & ARCHER C. (1989) The choice of an experimental model: A guide for research workers. J. Bone Joint Surg. 71B, 549-553.
26. SHOLTER D. & JONES N. (1965) Rheumatic manifestations of inherited diseases. Curr. Opin. Rheumatol. 9, 80-82.
27. SPENCER J.D. & BROOKES M. (1988) Avascular necrosis and the blood supply of the femoral head. Clin. Orthop. 235, 127-140.
28. TAKAOKA K., YOSHIOKA T., HOSOYA T., ONO K. & TAKASE T. (1981) The repair process in experimentally induced avascular necrosis of the femoral head in dogs. Arch. Trauma. Surg. 99, 109-115.
29. TAKASHI A. & YOSHIKATSU K. (1992) Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis. Clin. Orthop. 277, 22-30.
30. USUI Y., KAWAI K. & HIROHATA K. (1989) An electronmicroscopic study of changes observed in osteocytes under ischaemic conditions. J. Orthop. Res. 7, 12-21.
31. YAMAMOTO T., HIRANO K., TSUTSUI H., SUGIOKA Y. & SUEISHI K. (1995) Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction. Clin. Orthop 316, 235-243.