Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules

Human Immunology

Volumn 59, Issue 7, 1998, Pages 415-425

  Graeb, Christian ^a   Scherer, Marcus N ^a   Knechtle, Stuart J ^b   Geissler, Edward K ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ADOPTIVE TRANSFER; ARTICLE; CYTOTOXIC T LYMPHOCYTE; GRAFT SURVIVAL; IMMUNOMODULATION; LIVER CELL CULTURE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0031826683     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(98)00037-8     Document Type: Article

References (55)

1. Davies HfS, Pollard S.G., Calne R.Y. Soluble HLA antigens in the circulation of liver graft recipients. Transplantation. 47:1989;524.
2. Flye M.W., Duffy B.F., Phelan D.L., Ratner L.E., Mohanakumar T. Protective effects of liver transplantation on a simultaneously transplanted kidney in a highly sensitized patient. Transplantation. 50:1990;1051.
3. Starzl T.E., Demetris A.J., Trucco M., Murase N., Ricordi C., ldstad S., Ramos H., Todo S., Tzakis A., Fung J.J., Nalesnik M., Zeevi A., Rudert W.A., Kocova M. Cell migration and chimerism after whole-organ transplantation the basis of graft acceptance . Hepatology. 17:1993;1127.
4. Kamada N. The immunology of experimental liver transplantation in the rat. Immunology. 55:1985;369.
5. Calne R., Davies H. Organ graft tolerance the liver effect . Lancet. 343:1994;67.
6. Kamada N. Transplantation tolerance and immunosuppression following liver grafting in rats. Immunol Today. 6:1985;336.
7. Kamada N., Davies HfS, Roser B. Reversal of transplantation immunity by liver grafting. Nature. 292:1981;840.
8. Sumimoto R., Shinomiya T. Examination of serum class I antigen in liver-transplanted rats. Clin Exp Immunol. 85:1991;114.
9. Spencer S.C., Fabre J.W. Bulk purification of a naturally occurring soluble form of RT1-A Class I major histocompatibility complex antigens from DA rat liver, and studies of specific immunosuppression. Transplantation. 44:1987;141.
10. Madsen J., Superina R.A., Wood K.J., Morris P.J. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature. 332:1988;161.
11. Yamaguchi Y., Harland R.C., Wyble C., Bollinger R.R. The effect of pretreatment with class I major histocompatibility complex (MHC) antigens on hepatic or cardiac allograft survival in the rat. Transplant Proc. 21:1989;3555.
12. Foster S., Cranston D., Wood K.J., Morris P.J. Production of indefinite renal allograft survival in the rat by pretreatment with viable and nonviable hepatocytes or liver membrane extracts. Transplantation. 45:1987;228.
13. Foster S., Wood K.J., Morris P.J. The effectiveness of pretreatment with soluble or membrane-bound donor class I major histocompatibility complex antigens in the induction of unresponsiveness to a subsequent rat renal allograft. Transplantation. 53:1992;1322.
14. Rogers J., Mescher M.F. Augmentation of in vivo cytotoxic T lymphocyte activity and reduction of tumor growth by large multivalent immunogen. J Immunol. 149:1992;269.
15. Geissler E.K., Wang J., Fechner J.H., Burlingham W.J., Knechtle S.J. Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle. J Immunol. 152:1994;413.
16. Abastado J.P., Lone Y.C., Casrouge A., Boulot G., Kourilsky P. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J Exp Med. 182:1995;439.
17. Zavazava N., Hausmann R., Muller-Ruchholtz W. Inhibition of anti-HLA-B7 alloreactive CTL by affinity-purified soluble HLA. Transplantation. 51:1991;838.
18. Hausmann R., Zavazava N., Steinmann J., Muller-Ruchholtz W. Interaction of papain-digested class I molecules with human alloreactive cytotoxic T lymphocytes (CTL). Clin Exp Immunol. 91:1993;183.
19. Dal Porto J., Johansen T.E., Catipovic B., Parfiit D.J., Tuveson D., Gether U., Kozlowski S., Fearon D.T., Schneck J.P. A soluble divalent class I major histocompatibilty complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc Natl Acad Sci USA. 90:1993;6671.
20. Zavazava N., Kronke M. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nature Med. 2:1996;1005.
21. Geissler E.K., Korzun W.J., Graeb C. Secreted donor-MHC class I antigen prolongs liver allograft survival and inhibits recipient anti-donor cytotoxic T lymphocyte responses. Transplantation. 64:1997;782.
22. Mann D.W., Stroynowski I., Hood L., Forman J. Cytotoxic T lymphocytes from mice with soluble Class I Q10 molecules in their serum are not tolerant to membrane-bound Q10. J Immunol. 138:1987;240.
23. Arnold B., Dill O., Kublbeck G., Jatsch L., Simon M.M., Tucker J., Hammerling G.J. Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form. Proc Natl Acad Sci USA. 85:1988;2269.
24. Grumet F.C., Krishnaswamy S., See-Tho K., Filvaroff E., Hiraki D.D. Soluble form of an HLA-B7 class I antigen specifically suppresses humoral alloimmunization. Hum Immunol. 40:1994;228.
25. Sumimoto R., Kamada N. Specific suppression of allograft rejection by soluble class I antigen and complexes with monoclonal antibody. Transplantation. 50:1990;678.
26. Seglen P.O. Isolation of hepatocytes by collagenase perfusion. Methods Toxicol. 1:1993;231.
27. Graeb C., Geissler E.K. Effect of portal vein injection of allo-MHC-transfected hepatocytes on immunity prior to organ transplantation. Transplant Proc. 29:1997;1017.
28. Stepkowski S.M., Ito T. Frequency of alloantigen-specific T cytotoxic cells in high- and low-responder recipients of class I MHC-disparate heart allografts. Transplantation. 50:1990;112.
29. Clement J.D., Chan S.Y., Bishop D.K. Allogeneic class I MHC requirement for alloantigen-reactive helper T-lymphocyte responses in vivo. Transplantation. 62:1996;388.
30. Derry H., Miller R.G. Measurement and calculation of CTL-P frequencies. Fathman C.G., Fitch F.W. Isolation, Characterization, and Utilization of T Lymphocyte Clones. 1982;Academic Press, New York.
31. Gassel H.J., Hutchinson I.V., Engemann R., Morris P.J. The role of T suppressor cells in the maintenance of spontaneously accepted orthotopic rat liver allografts. Transplantation. 54:1992;1048.
32. Knechtle S.J., Wang J., Graeb C., Zhai Y., Hong X., Fechner J.H., Geissler E.K. Direct MHC class I complementary deoxyribonucleic acid transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms. J Immunol. 159:1997;152.
33. Ono K., Lindsey E.D. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 57:1969;225.
34. SAS/STAT User's Guide. 1989;SAS Institute Inc, Cary, NC.
35. Geissler EK, Scherer MN, Graeb C: Soluble donor MHC class I antigen inhibits immunologic priming in vitro and in vivo. Transpl Int (in press).
36. Wang J., Geissler E.K., Fechner J.H., Burlingham W.J., Knechtle S.J. Use of donor serum to prevent passive transfer of hyperacute rejection. J Surg Res. 57:1994;150.
37. Goto S., Kamada N., Lotz M., Kobayashi E., Enosawa S., Kipps T.J. Induction of natural chimerism after retransplantation of the liver in rats. Transplantation. 58:1994;1230.
38. Callery M.P., Kamei T., Flye M.W. The anatomic site-specificity of tolerance indution to alloantigen. Transplantation. 49:1990;230.
39. Squiers E.C., Salomon D.R., Pickard L.L., Howard R.R., Pfaff W.W. Abrogation of the induction of portal venous tolerance in a cardiac transplant model resulting from Kupffer cell inhibition by gadolinium. Transplantation. 50:1990;171.
40. Lowry R.P., Forbes R.D.C., Blackburn J.H., Marghesco D.M. Immune mechanisms in organ allograft rejection V.Pivotal role of the cytotoxic suppressor T-cell subset in the rejection of heart grafts bearing isolated class I disparate in the inbred rat . Transplantation. 40:1982;432.
41. Hall B.M., Gurley K.E., Dorsch S.E. The possible role of cytotoxic T cells in the mediation of the first-set allograft rejection. Transplantation. 40:1985;336.
42. DeSilva D.R., Urdahl K.B., Jenkins M.K. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol. 147:1991;3261.
43. Mellor A.L., Weiss E.H., Kress M., Jay G., Flavell R.A. A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell. 36:1984;139.
44. Lew A.M., Maloy W.L., Coligan J.E. Characteristics of the expression of the murine soluble class I molecule (Q10). J Immunol. 136:1986;254.
45. Buelow R., Burlingham W.J., Clayberger C. Immunomodulation by soluble HLA class I. Transplantation. 59:1995;649.
46. Lehmann M., Graser E., Risch K., Hancock W.W., Muller A., Kuttler B., Hahn H.J., Kupiec-Weglinski J.W., Brock J., Volk H.D. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation. 64:1997;1181.
47. So S.K.S., Wilkes L.M., Platt J.L., Ascher N.L., Simmons R.L. Purified hepatocytes can stimulate allospecific cytolytic T lymphocytes in a mixed lymphocyte-hepatocyte culture. Transplant Proc. 19:1987;251.
48. Brent L., Bain A.G., Butler R., Horsburgh T., Opara S.C., Wood P.J. The antigenicity of purified liver parenchyma cells. Transplant Proc. 13:1981;860.
49. Jones-Youngblood S.L., Wieties K., Forman J., Hammer R.E. Effect of the expression of a hepatocyte-specific MHC molecule in transgenic mice on T cell tolerance. J Immunol. 144:1990;1187.
50. Kreamer B.L., Staecker J.L., Sawada N., Sattler G.L., Hsia M.T.S., Pitot H.C. Use of a low-speed, iso-density Percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro. 22:1986;201.
51. Davies J.D., Martin G., Phillips J., Marshall S.E., Coffman T.M., Waldmann H. T cell regulation in adult transplantation tolerance. J Immunol. 157:1996;529.
52. Thomas J.M., Carver F.M., Cunningham P.R.G., Olson L.C., Thomas F.T. Kidney allograft tolerance in primates without chronic immunosuppression - The role of veto cells. Transplantation. 51:1991;198.
53. Planz O., Seiler P., Hengartner H., Zinkernagel R.M. Specific cytotoxic T cells eliminate cells producing neutralizing antibodies. Nature. 382:1996;726.
54. Hall B.M., Pearce N.W., Gurley K.E., Dorsch S.E. Specifc unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine III. further characterization of the CD4-suppressor cell and its mechanisms of action. J Exp Med. 171:1990;141.
55. Miller R.G., Sheng-Tanner X. Correlation between lymphocyte-induced donor-specific tolerance and doner cell recirculation. J Exp Med. 176:1992;407.