4-Aminopyridine derivatives: A family of novel modulators of voltage-dependent sodium channels

Drug Development Research

Volumn 44, Issue 1, 1998, Pages 8-13

  Tang, Lei ^a   Huger, Francis P ^a   Klein, Joseph T ^a   Davis, Larry ^a   Martin, Lawrence L ^a   Shimshock, Stephen ^a   Effland, Richard C ^a   Smith, Craig P ^a   Kongsamut, Sathapana ^a,b  

^a Hoechst Marion Roussel   (United States)

^b NONE   (United States)

Author keywords

4 aminopyridine derivative; Anticonvulsant; Batrachotoxin; Besipirdine; SAR; Sodium channel

Indexed keywords

AMINOPYRIDINE DERIVATIVE; BATRACHOTOXIN; BESIPIRDINE; SODIUM CHANNEL; VERATRIDINE;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; IN VITRO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME;

EID: 0031826551     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199805)44:1<8::AID-DDR2>3.0.CO;2-L     Document Type: Article

References (20)

1. 3H]-Batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: Inhibition by the channel blockers tetrodotoxin and saxitoxin. J Neurosci 6:2064-2070.
2. Catterall WA (1977): Activation of action potential sodium ionophore by neurotoxins: An allosteric model. J Biol Chem 252:8669-8676.
3. Catterall WA (1986): Molecular properties of voltage-sensitive sodium channels. Ann Rev Biochem 55:953-985.
4. + channels: Local anesthetics, antiarrhythmics and anticonvulsants. Trends Pharm Sci 8:57-65.
5. Cornfeldt M, Wirtz-Brugger F, Szewczak MR, Blitzer R, Landau E, Haroutunian V, Effland RC, Klein JT, Smith CP (1990): HP 749 (I): A pharmacological profile of a therapeutic agent for Alzheimer's disease. Soc Neurosci Abstr 16:612.
6. Courtney KR, Strichartz JM (1987); Structural elements which determine local anesthetic activity. In Strichartz GR (ed): Local Anesthetics, Handbook of Experimental Pharmacology, Vol. 81. Berlin: Springer-Verlag, pp 53-94.
7. Fischer W, Bodewei R, Satzinger G (1992): Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Naunyn Schmiedebergs Arch Pharmacol 346:442-452.
8. Gladding CD, Kupferberg HJ, Swinyard EA (1985): Antiepileptic drag development program. In Frey HH, Janz D (eds): Antiepileptic Drugs, Handbook of Experimental Pharmacology, Vol. 74. Berlin: Springer-Verlag, pp 342-347.
9. Huger FP, Smith CP, Petko WW, Conway PG, Effland RC, Klein JT (1990). HP 749. A potential therapeutic agent for Alzheimer's disease. II. Neurochemical profile. Soc Neurosci Ahstr 16:612.
10. Klein JT, Davis L, Olsen GE, Wong GS, Huger FP, Smith CP, Petko WW, Cornfeldt ML, Wilker JC, Blitzer RD, Landau E, Haroutunian V Martin LL, Effland RC (1996): Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (hesipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. J Med Chem 39:570-581.
11. + channels by local anesthetics. Science 265:1724-1728.
12. Santucci AC, Haroutunian V, Davis KL (1991): Pharmacological alleviation of combined cholinergic/noradrenergic lesion-induced memory deficits in rats. Clin Neuropharmacol 14(Suppl 1):S1-S8.
13. Sheldon RS, Hill RJ, Taouis M, Wilson LM (1991): Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes. Mol Pharmacol 39:609-614.
14. 3H]batrachotoxinin binding to rat cardiac sodium channels. J Pharmacol Exp Ther 268:187-194.
15. 3H]norepinephrine release from rat cortical slices by N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine. Drug Dev Res 32:13-18.
16. Strichartz GR, Ritchie JM (1987): The action of local anesthetic on ion channels of excitable tissues. In Strichartz. GR (ed): Local Anesthetics, Handbook of Experimental Pharmacology, Vol. 81. Berlin: Springer-Verlag, pp 21-53.
17. Tang L, Kongsamut S (1996): Frequency dependent inhibition of neurotransmitter release by besipirdine and HP 184. Eur J Pharmacol 300:71-74.
18. Tang L, Smith CP, Huger FP, Kongsamut S (1995): Besipirdine inhibits effects of veratridine at the voltage dependent sodium channel. Br J Pharmacol 116:2468-2472.
19. 3H]batrachotoxin A 20-α-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol 22:627-635.
20. Willow M, Gonoi T, Catterall WA (1985): Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol Pharmacol 27:549-558.