Ubiquinone supplementation during lovastatin treatment: Effect on LDL oxidation ex vivo

Journal of Lipid Research

Volumn 39, Issue 7, 1998, Pages 1430-1437

  Palomäki, Ari ^a   Malminiemi, Kimmo ^b,c   Solakivi, Tiina ^b,c   Malminiemi, Outi ^c  

^a KANTA HÄME CENTRAL HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

tocopherol; AMVN; Clinical trial; Coenzyme Q10; Copper induced oxidation; HMG CoA reductase inhibitors; Lipid oxidation; Oxidation kinetics; Statins; Ubiquinol

Indexed keywords

LOW DENSITY LIPOPROTEIN; MEVINOLIN; UBIQUINONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG POTENTIATION; HUMAN; HYPERCHOLESTEROLEMIA; KINETICS; LIPID OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ANALYSIS OF VARIANCE; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; CHOLESTEROL; COPPER SULFATE; CORONARY DISEASE; CROSS-OVER STUDIES; DIET; DOUBLE-BLIND METHOD; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LOVASTATIN; MALE; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; TRIGLYCERIDES; UBIQUINONE;

EID: 0031826167     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Shepherd, J., S. M. Cobbe, I. Ford, C. G. Isles, A. R. Lorimer, P. W. Macfarlane, J. H. McKillop, C. J. Packard, and West of Scotland Coronary Prevention Study Group. 1995. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med. 333: 1301-1307.
2. Scandinavian Simvastatin Survival Study Group. 1994. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 344: 1383-1389.
3. Watts, G. F., and V. Burke. 1996. Lipid-lowering trials in the primary and secondary prevention of coronary heart disease: new evidence, implications and outstanding issues. Curr. Opin. Lipidol. 7: 341-355.
4. Lehninger, A. L., D. L. Nelson, and M. M. Cox. 1993. Principles of Biochemistry. 2nd ed. Worth Publishers, Inc., New York, NY. 669-683.
5. Appelkvist, E. L., C. Edlund, P. Löw, S. Schedin, A. Kalén, and G. Dallner. 1993. Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosyntesis. Clin. Invest. 71: S97-S102.
6. 10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J. Clin. Pharmacol. 33: 226-229.
7. Laaksonen, R., J-P. Ojala, M. J. Tikkanen, and J-J. Himberg. 1994. Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors. 1994. Eur. J. Clin. Pharmacol. 46: 313-317.
8. Davidson, M., J. McKenney, E. Stein, H. Schrott, R. Bakker-Arkema, R. Fayyad, and D. Black, for the Atorvastatin Study Group I. 1997. Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Am. J. Cardiol. 79: 1475-1481.
9. Okamoto, T., M. Fukui, M. Nakamoto, T. Kishi, N. Kanamori, K. Kataoka, S. Nishii, H. Kishi, E. Hiraoka, and A. Okada. 1986. Serum levels of coenzyme Q10 and lipids in patients during total parenteral nutrition. J. Nutr. Sci. Vitaminol. 32: 1-12.
10. Åberg, F., E-L. Appelkvist, G. Dallner, and L. Ernster. 1992. Distribution and redox state of ubiquinones in rat and human tissues. Arch. Biochem. Biophys. 295: 230-234.
11. Kontush, A., C. Hübner, B. Finckh, A. Kohlschütter, and U. Beisiegel. 1994. Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol-10 and polyunsaturated fatty acid content. FEBS Lett. 341: 69-73.
12. Willis, R. A., K. Folkers, J. L. Tucker, C-Q. Ye, L-J. Xia, and H. Tamagawa. 1990. Lovastatin decreases coenzyme Q levels in rats. Proc. Natl. Acad. Sci. USA. 87: 8928-8930.
13. 10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Int. J. Clin. Lab. Res. 24: 171-176.
14. 10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim. Biophys. Acta. 1126: 247-254.
15. Kontush, A., C. Hübner, B. Finckh, A. Kohlschütter, and U. Beisiegel. 1995. Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low density lipoprotein. Biochim. Biophys. Acta. 1258: 177-187.
16. Esterbauer, H., J. Gebicki, H. Puhl, and G. Jurgens. 1992. The role of lipid peroxidation and antioxidants in oxidative modification in LDL. Free Radical Biol. Med. 13: 341-390.
17. Frei, B., and J. M. Gaziano. 1993. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J. Lipid. Res. 34: 2135-2145.
18. Palomäki, A., K. Malminiemi, and T. Metsä-Ketelä. 1997. Enhanced oxidizability of ubiquinol and α-tocopherol during lovastatin treatment. FEBS Lett. 410: 254-258.
19. EC Note for Guidance. 1990. Good Clinical Practice for Trials on Medicinal Products in the European Community. III/3976/88-EN.
20. Chung, B. H., J. P. Segrest, M. J. Ray, J. D. Brunzell, J. E. Hokansson, R. M. Krauss, K. Beaudrie, and J. T. Cone. 1986. Single vertical spin gradient ultracentrifugation. Methods Enzymol. 128: 181-209.
21. Markwell, M. A. K., S. M. Hass, N. E. Tolbert, and L. L. Bieber. 1981. Protein determination in membrane and lipoprotein samples: manual and automatic procedures. Methods Enzymol. 123: 293-303.
22. Esterbauer, H., G. Striegl, H. Puhl, and M. Rotheneder. 1989. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radical Res. Commun. 6: 67-75.
23. Ramos, P., S. P. Gieseg, B. Schuster, and H. Esterbauer. 1995. Effect of temperature and phase transition on oxidation resistance of low density lipoprotein. J. Lipid Res. 36: 2113-2128.
24. Wieland, H., and D. Seidel. 1983. A simple specific method for precipitation of low density lipoproteins. J. Ljpid Res. 24: 904-909.
25. Zar, J. H. 1984. Biostatistical Analysis. 2nd ed. Prentice-Hall International Inc., London, UK. 162-171.
26. Pocock, S. J. 1983. Clinical Trials. A Practical Approach. John Wiley & Sons Ltd., Chichester, UK. 116-119.
27. Hintze, J.L. 1991. BMDP SOLO Statistical Programs. Version 4.0. BMDP Statistical Software Inc., Los Angeles, CA, USA.
28. Tribble, D. L., J. J. M. van den Berg, P. A. Motchnik, B. N. Ames, D. M. Lewis, A. Chait, and R. M. Krauss. 1994. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and α-tocopherol content. Proc. Natl. Acad. Sci. USA. 91: 1183-1187.
29. Kleinveld, H. A., L. M. Hak-Leemers, A. F. H. Stalenhoef, and P. N. M. Demacker. 1992. Improved measurement of low-density lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolation low-density lipoprotein. Clin. Chem. 38: 2066-2072.
30. Esterbauer, H., M. Dieber-Rotheneder, G. Striegl, and G. Waeg. 1991. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am. J. Clin. Nutr. 53: 314S-321S.
31. Giessauf, A., E. Steiner, and H. Esterbauer. 1995. Early destruction of tryptophan residues of apolipoprotein B is a vitamin E-independent process during copper-mediated oxidation of LDL. Biochim. Biophys. Acta. 1256: 221-232.
32. Witting, P. K., V. W. Bowry, and R. Stocker. 1995. Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol-mediated peroxidation of LDL lipids. FEBS Lett. 375: 45-49.
33. Frei B., M. C. Kim, and B. N. Ames. 1990. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. USA. 87: 4879-4883.
34. Stocker, R., V. W. Bowry, and B. Frei. 1991. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. USA. 88: 1646-1650.
35. Suarna C., R. L. Hood, R. T. Dean, and R. Stocker. 1993. Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogenous system, and in rat and human lipoproteins. Biochem. Biophys. Acta. 1166: 163-170.
36. Lilja, J., R. Laaksonen, J. Laakso, M. J. Tikkanen, and J. J. Himberg. 1996. Does oral ubiquinone supplementation have an antioxidant affect on LDL? 66th Congress of the European Atherosclerosis Society, Florence, Italy, July 13-17, 1996. Abstract book p. 134.
37. Kaikkonen, J., K. Nyyssönen, P. Porkkala-Sarataho, H. E. Poulsen, T. Metsä-Ketelä, M. Hayn, R. Salonen, and J. T. Salonen. 1997. Effect of oral coenzymc Q10 supplementation on the oxidation resistance of human VLDL + LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radical Biol. Med. 22: 1195-1202.
38. Jialal, I., C. J. Fuller, and B. A. Huet. 1995. The effect of α-tocopherol supplementation on LDL oxidation. A dose-response study. Arterioscler. Thromb. Vasc. Biol. 15: 190-198.
39. Thomas, S. R., J. Neuzil, and R. Stocker. 1996. Cosupplementation with coenzyme Q prevents the pro-oxidant effect of α-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation. Arterioscler. Thromb. Vasc. Biol. 16: 687-696.
40. Shaish, A., A. Daugherty, F. O'Sullivan, G. Schonfeld, and J. W. Heinecke. 1995. Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J. Clin. Invest. 96: 2075-2082.
41. Fruebis, H., D. Steinberg, H. A. Dresel, and T. E. Carew. 1994. A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits. J. Clin. Invest. 94: 392-398.
42. Keaney, J. F., Jr., J. M. Gaziano, A. Xu, B. Frei, J. Curran-Celentano, G. T. Shwaery, J. Loscalzo, and J. A. Vita. 1993. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterolled rabbits. Proc. Natl. Acad. Sci. USA. 90: 11880-11884.
43. Diaz, M.N., B. Frei, J. A. Vita, and J. F. Keaney, Jr. 1997. Antioxidants and atherosclerotic heart disease. N. Engl. J. Med. 337: 408-416.
44. Baehner, R., L. Boxer, and L. Ingraham. 1982. Vitamin E - a membrane antioxidant in PMN. In Free Radicals in Biology. W. A. Pryor, editor. Academic Press, New York. 5: 103-104.
45. Forman, H. J., and A. Boveris. 1982. Superoxide radical as precursor of mitochondrial hydrogen peroxide. In Free Radicals in Biology. W. A. Pryor, editor. Academic Press, New York. 5: 77-82.
46. de Rijke, Y. B., S. J. H. Bredie, P. N. M. Demacker, J. M. Vogelaar, H. L. M. Hak-Lemmers, and A. F. H. Stalenhoef. 1997. The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Arterioscler. Thromb. Vasc. Biol. 17: 127-133.
47. Maguire, J. J., V. Kagan, B. A. C. Ackrell, E. Serbinova, and L. Packer. 1992. Succinate-ubiquinone reductase linked recycling of α-tocopherol in reconstituted systems and mitochondria: requirement for reduced ubiquinone. Arch. Biochem. Biophys. 292: 47-53.
48. Brown, B. G., X-Q. Zhao, J. Bardsley, and J. J. Albers. 1997. Secondary prevention of heart disease amongst patients with lipid abnormalities: practice and trends in the United States. J. Intern. Med. 241: 283-294.
49. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. 1993. Summary of the second report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel II). J. Am. Med. Assoc. 269: 3015-3023.