Cytotoxic and genotoxic effects of Paclitaxel (Taxol®) and radiation in a squamous cell carcinoma cell line of the larynx

Acta Oto-Laryngologica

Volumn 118, Issue 4, 1998, Pages 600-605

  Preisler, Verena K ^a   Stopper, Helga ^a   Schindler, Detlev ^a   Friedl, Richard ^a   Pfreundner, Leo ^a   Hoppe, Florian ^a   Hagen, Rudolf ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cytotoxic genotoxic effects; Human laryngeal carcinoma cell line; Paclitaxel (Taxol ); Radiation sensitizing

Indexed keywords

PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GENOTOXICITY; HUMAN; HUMAN CELL; LARYNX CARCINOMA; PRIORITY JOURNAL; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; FLOW CYTOMETRY; HUMANS; LARYNGEAL NEOPLASMS; PACLITAXEL; RADIATION DOSAGE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0031825803     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016489850154793     Document Type: Article

References (25)

1. Rowinsky EK, Cazenave LA, Donehower RC. Taxol: a novel investigational antimicrotubule agent. J Natl Cancer Inst 1990; 82: 1247-59.
2. Runowicz CD, Wiernik PH, Einzig AI. Taxol in ovarian cancer. Cancer 1993; 71: 1591-6.
3. Arbuck SG, Blaylock BA. Taxol: clinical results and current issues in development. In: Suffness M, ed. Taxol: science and applications. Boca Raton. FL: CRC Press, 1995: 379-415
4. Forastiere AA. Paclitaxel (Taxol) for the treatment of head and neck cancer. Semin Oncol 1994; 21: 49-52.
5. Frei E III. Combination cancer therapy: presidential address. Cancer Res 1972; 32: 2593-607.
6. Horwitz SB. Mechanism of action of Taxol. Trends Pharmacol Sci 1992; 13: 134-6.
7. Horwitz SB. Taxol (paclitaxel). Mechanism of action. Ann Oncol 1994; 5: 53-6.
8. Cook JA, Teague D, Fisher J. Radiosensitization of Chinese hamster V79 cells by taxol. Radiat Oncol Invest 1993; 1: 103-10.
9. Sinclair WK. Cyclic X-ray responses in mammalian cells in vitro. Radiat Res 1968; 33: 620-43.
10. Tishler RB, Schiff PB, Geard CR, Hall EJ. Taxol: a novel radiation sensitizer. Int J Radiat Oncol Biol Phys 1992; 22: 613-7.
11. Zenner HP, Lehner W, Herrmann IF. Establishment of carcinoma cell lines from larynx and submandibular gland. Arch Otorhinolaryngol 1979; 225: 269-77.
12. Rownisky EK, Donehower RC, Jones RJ, Tucker RW. Microtubule changes and cytotoxicity in leukaemic cell lines treated with taxol. Cancer Res 1988; 48: 4093-100.
13. Tishler RB, Geard CR, Hall EJ, Schiff PB. Taxol sensitizes human astrocytoma cells to radiation. Cancer Res 1992; 52: 3495-7.
14. Hanauske AR, Degen D, Hilsenbeck SG. Effects of taxotere and taxol on in vitro colony formation of freshly explanted tumor cells. Anticancer Drugs 1992; 3: 121-4.
15. Elomaa L, Joensuu H, Kulmala J. Squamous cell carcinoma is highly sensitive to taxol, a possible new radiation sensitizer. Acta Otolaryngol (Stockh) 1995; 115: 340-4.
16. Matsuoka H, Furusawa M, Tomoda H, Seo Y. Difference in cytotoxicity of paclitaxel against neoplastic and normal cells. Anticancer Res 1994; 14: 163-7.
17. Choy H, Rodriguez FF, Koester S. Investigation of taxol as a potential radiation sensitizer. Cancer 1993; 71: 3774-8.
18. R). Int J Radiat Oncol Biol Phys 1994; 29: 559-64.
19. Steren A, Sevin B, Perras J. Taxol sensitizes human ovarian cancer cells to radiation. Gynecol Oncol 1993; 48: 252-8.
20. Geard CR, Jones JM. Radiation and taxol effects on synchronized human cervical carcinoma cells. Int J Radiat Oncol Biol Phys 1994; 29: 565-9.
21. Geard CR, Jones JM, Schiff PB. Taxol and radiation. J Natl Cancer Inst 1993; 15: 89-94.
22. Jagetia GC, Adiga SK. Influence of various concentrations of taxol on cell survival, micronuclei induction, and LDH activity in cultured V79 cells. Cancer Lett 1995; 96: 195-200.
23. Jordan MA, Wendell K, Gardiner S. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-25.
24. Shibamoto Y, Shibata T, Miyatake S. Assessment of the proliferative activity and radiosensitivity of human tumours using the cytokinesis-block micronucleus assay. Br J Cancer 1994; 70: 67-71.
25. Streffer C. Is the micronucleus assay predictive for cellular radiosensitivity? Br J Radiol 1992; 24: 70-3.