Effects of granulocyte colony-stimulating factor in healthy subjects

Current Opinion in Hematology

Volumn 5, Issue 3, 1998, Pages 209-214

  Körbling, Martin ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CD34 ANTIGEN; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LACTATE DEHYDROGENASE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ALLOTRANSPLANTATION; APHERESIS; BLOOD DONOR; BLOOD LEVEL; BONE PAIN; CELL KINETICS; CELL MOTILITY; CLINICAL TRIAL; CLONOGENESIS; CYTOKINE RESPONSIVE ELEMENT; FATIGUE; GRAFT VERSUS HOST REACTION; GRANULOCYTE; HEADACHE; HUMAN; LEUKOCYTE; LEUKOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MONOCYTE; MYALGIA; NAUSEA; NORMAL HUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; STEM CELL; SYSTEMIC CIRCULATION; T LYMPHOCYTE;

EID: 0031825766     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199805000-00011     Document Type: Review

References (60)

1. dim) and lymphoid subsets, and possible predictors of engraftment and GVHD. Blood 1995, 86:2842-2848.
2. Bensinger WI, Price TH, Dale DC, Appelbaum FR, Clift R, Lilleby K, Williams B, Storb R, Thomas ED, Buckner CD: The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis. Blood 1993, 81:1883-1888.
3. Caspar CB, Seger RA, Burger J, Gmur J: Effective stimulation of donors for granulocyte transfusions with recombinant methionyl granulocyte colony-stimulating factor. Blood 1993, 81:2866-2871.
4. Ali SM, Brown RA, Adkins DR, Todd G, Haug JS, Goodnough LT, DiPersio JF: Analysis of lymphocyte subsets and peripheral progenitor cells in apheresis products from normal donors mobilized with either G-CSF or concurrent G-CSF and GM-CSF. Blood 1997, 90(suppl 1):564a.
5. Lane TA, Law P, Maruyama M, Young D, Burgess J, Mullen M, Mealiffe M, Terstappen LW, Hardwick A, Moubayed M, et al.: Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor or G-CSF: potential role in allogeneic marrow transplantation. Blood 1995, 85:275-282.
6. Weaver CH, Longin K, Buckner CD, Bensinger W: Lymphocyte content in peripheral blood mononuclear cells collected after administration of recombinant human granulocyte colony-stimulating factor. Bone Marrow Transplant 1994, 13:411-415.
7. Sica S, Rutella S, Di Mario A, Salutari P, Rumi C, Ortu la Barbera E, Etuk B, Menichella G, D'Onofrio G, Leone G: rhG-CSF in healthy donors: mobilization of peripheral hemopoietic progenitors and effect on peripheral blood leukocytes. J Hematother 1996, 5:391-397.
8. Anderlini P, Przepiorka D, Seong D, Miller P, Sundberg J, Lichtiger B, Norfleet F, Chan K, Champlin R, Korbling M: Clinical toxicity and laboratory effects of granulocyte-colony-stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the procedure. Transfusion 1996, 36:590-595.
9. + cells derived from granulocyte colony stimulating factor-mobilized peripheral blood mononuclear cells. Blood 1997, 89:1629-1634.
10. Zeng D, Dejbakhsh-Jones S, Strober S: Granulocyte colony-stimulating factor reduces the capacity of blood mononuclear cells to induce graft-versus-host disease: impact on blood progenitor cell transplantation. Blood 1997, 90:453-463.
11. +) in the blood of normal donors. Blood 1997, 89:2586-2595.
12. Miller JS, Prosper F, McCullar V: Natural killer (NK) cells are functionally abnormal and NK cell progenitors are diminished in granulocyte colony stimulating factor-mobilized peripheral blood progenitor cell collections. Blood 1997, 90:3098-3105.
13. Chatta GS, Price TH, Allen RC, Dale DC: Effects of in vivo recombinant methionyl human granulocyte colony-stimulating factor on the neutrophil response and peripheral blood colony-forming cells in healthy young and elderly adult volunteers. Blood 1994, 84:2923-2929.
14. Stroncek DF, Clay ME, Petzold ML, Smith J, Jaszcz W, Oldham FB, McCullough J: Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells. Transfusion 1996, 36:601-610.
15. DeHaas M, Kerst JM, van der School C, Calafat J, Hach CE, Nuijens JH, Roos D, van Oers RHJ, von dem Borne EGK: Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effect on circulating neutrophils. Blood 1994, 84:3885-3894.
16. Roilides E, Walsh TJ, Pizzo PA, Rubin M: Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis 1991, 163:579-583.
17. Yuo A, Kitagawa S, Ohsaka A, Ohta M, Miyazono K, Okabe T, Urabe A, Saito M, Takaku F: Recombinant human granulocyte colony-stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor-mediated agonists and stimulation of C3bi receptor expression and adherence. Blood 1989, 74:2144-2149.
18. Tsuruta T, Tani K, Shimane M, Ozawa K, Takahashi S, Tsuchimoto D, Takahashi K, Nagata N, Sato N, Asano S: Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defensin and granulocyte colony-stimulating factor receptor mRNA expression in haematopoietic cells of normal individuals and myeloid disorders. Br J Haematol 1996, 92:9-22.
19. 1 integrin expression and function. Blood 1997, 90(suppl 1 ):260a.
20. Link H, Arseniev L, Bähre O, Berenson RJ, Battmer K, Kadar JG, Jacobs R, Casper J, Kuhl J, Schubert J, et al.: Combined transplantation of allogeneic bone marrow and CD34+ blood cells. Blood 1995, 86:2500-2508.
21. Fujisaki T, Otsuka T, Harada M, Ohno Y, Niho Y: Granulocyte colony-stimulating factor mobilizes primitive hematopoietic stem cells in normal individuals. Bone Marrow Transplant 1995, 16:57-62.
22. Tjønnfjord GE, Steen R, Evensen SA, Thorsby E, Egeland T: Characterization of CD34+ peripheral blood cells from healthy adults mobilized by recombinant human granulocyte-stimulating factor. Blood 1994, 84:2795-2801.
23. Grigg AP, Roberts AW, Raunow H, Houghton S, Layton JE, Boyd AW, McGrath KM, Maher D: Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 1995, 86:4437-4445.
24. Dreger P, Haferlach T, Eckstein V, Tanaka R, Matsudaira T, Tanaka I, et al.: Kinetics and characteristics of peripheral blood progenitor cells mobilized by G-CSF in normal healthy volunteers [abstract]. Blood 1994, 84(suppl 1):541a.
25. Stroncek DF, Clay ME, Herr G, Smith J, Jaszcz WB, Ilstrup S, McCullough J: The kinetics of G-CSF mobilization of CD34+ cells in healthy people. Transfus Med 1997, 7:19-24.
26. Jacobs S, Suttorp M, Loffler H, Muller-Ruchholtz W, Schmitz N: Filgrastim-mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics and mobilization, and composition of the graft. Br J Haematol 1994, 87:609-613.
27. Fujisaki T, Otsuka T, Harada M, Ohno Y, Niho Y: Granulocyte colony-stimulating factor mobilizes primitive hematopoietic stem cells in normal individuals. Bone Marrow Transplant 1995, 16:57-62.
28. Prosper F, Stroncek D, Verfaillie CM: Mobilization of LTC-IC in normal donors treated with G-CSF: phenotypic analysis of mobilized PBSC [abstract]. Blood 1995, 86:464a.
29. Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM: Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. Blood 1990, 76:2153-2158.
30. Höglund M, Smedmyr B, Simonsson B, Tötterman T, Bengtsson M: Dose-dependent mobilisation of haematopoietic progenitor cells in healthy volunteers receiving glycosylated rHuG-CSF. Bone Marrow Transplant 1996, 18:19-27.
31. Bensinger WI, Weaver CH, Appelbaum FR, Rowley S, Demirer T, Sanders J, Storb R, Buckner CD: Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor. Blood 1995, 85:1655-1658.
32. Stroncek D, Clay M, Lennon S, Smith J, McCullough J: Collection of two blood progenitor cell components from healthy donors [abstract]. Blood 1996, 88:396a.
33. Waller CF, Bertz H, Wenger MK, Fetscher S, Hardung M, Engelhardt M, Behringer D, Lange W, Mertelsmann R, Finke J: Mobilization of peripheral blood progenitor cells for allogeneic transplantation: efficacy and toxicity of a high-dose rhG-CSF regimen. Bone Marrow Transplant 1996, 18:279-283.
34. Matsunaga T, Sakamaki S, Kongo Y, Ohi S, Hirayama Y, Niitsu Y: Recombinant human granulocyte colony-stimulating factor can mobilize sufficient amounts of peripheral blood stem cells in healthy volunteers for allogeneic transplantation. Bone Marrow Transplant 1993, 11:103-108.
35. Kroger N, Zeller W, Hassan T, Kruger W, Hummel K, Goepfert C, Loliger C, Boermann B, Zander AR: 10 μg Versus 2 x 5 μg G-CSF in steady-state mobilization of CD34+ progenitor cells in high risk breast cancer patients: higher yield by splitting the dose. Blood 1997, 90(suppl 1):592a.
36. Hartung T, Docke WD, Gantner F, Krieger G, Sauer A, Stevens P, Volk HD, Wendel A: Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 1995, 85:2482-2489.
37. Pollmacher T, Korth C, Mullington J, Schreiber W, Sauer J, Vedder H, Galanos C, Holsboer F: Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men. Blood 1996, 87:900-905.
38. Mosmann TR, Coffman RL: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145-173.
39. Croft M, Carter L, Swain SL, Dutton RW: Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994, 180:1715-1728.
40. + T cells secreting Th1 or Th2 cytokines. Immunity 1995, 2:271-279.
41. Pan L, Delmonte J Jr, Jalonen CK, Ferrara JLM: Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft versus host disease. Blood 1995, 86:4422-4429.
42. Kadar JG, Arseniev L, Sosada M, Avenarius HJ, Schnittger K, Diedrich H, Sudmeier I, Zaki M, Battmer K, Stangel W, Link H: Prospective study of donor safety in growth factor mobilization and progenitor cell apheresis for allogeneic transplantation. Blood 1995, 86:579a.
43. Anderlini P, Przepiorka D, Champlin R, Körbling M: Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals. Blood 1996, 88:2819-2825.
44. Stroncek D, Clay M, Mills B, Oldham F, McCullough J: Experiences of normal individuals treated with granulocyte colony-stimulating factor. Blood 1994, 84:349a.
45. Becker PS, Wagle M, Matou S, Swanson RS, Pihan G, Lowry PA, Stewart FM, Heard SO: Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells. Biol Blood Marrow Transplant 1997, 3:45-49.
46. Parkhali T, Volin L, Siren MK, Ruutu T: Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer related peripheral blood progenitor cell donor. Bone Marrow Transplant 1996, 17:433-434.
47. Spitzer T, McAfee S, Poliquin C, Colby C: Acute gouty arthritis following recombinant human granulocyte colony-stimulating factor therapy in an allogeneic blood stem cell donor, [letter]. Bone Marrow Transplant 1998, in press.
48. Falanga A, Marchetti M, Oldani E, Giovanelli S, Barbu T: Changes of hemostatic parameters in healthy donors administered G-CSF for peripheral blood progenitor cells (PBPC) collection. Bone Marrow Transplant 1996, 17(suppl 2):S72.
49. Harada M, Nagafuji K, Fujisaki T, Kubota A, Mizuno S, Takenaka K, Miyamoto T, Ohno Y, Gondo H, Kuroiwa M, et al.: G-CSF-induced mobilization of peripheral blood stem cells from healthy adults for allogeneic transplantation. J Hematother 1996, 5:63-71.
50. Shimoda K, Okamura S, Inaba S, Okamura T, Ohga S, Ueda K, Niho Y: Granulocyte colony-stimulating factor and platelet aggregation [letter]. Lancet 1993, 341:633.
51. Avenarius HJ, Freund M, Deinhardt J, Poliwoda H: Effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on circulating platelets. Ann Hematol 1992, 65:6-9.
52. Anderlini P, Korbling M, Dale D, Gratwohl A, Schmitz N, Stroncek D, Howe C, Leitman S, Horowitz M, Gluckman E, et al.: Allogeneic blood stem cell transplantation: considerations for donors. Blood 1997, 90:903-908.
53. Bonilla MA, Dale D, Zeidler C, Last L, Reiter A, Ruggeiro M, Davis M, Koci B, Hammond W, Gillio A, et al.: Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (r-met-HuG-CSF) in patients with severe congenital neutropenias. Br J Haematol 1994, 88:723-730.
54. Sakamaki S, Matsunaga T, Hirayama Y, Kuga T, Niitsu Y: Haematological study of healthy volunteers 5 years after G-CSF [letter]. Lancet 1995, 346:1432-1433.
55. Hasenclever D, Sextro M: Safety of alloPBSCT donors: biometrical considerations on monitoring long term risks. Bone Marrow Transplant 1996, 17(suppl 2):S28-S30.
56. Gilman P, Jackson D, Guild H: Congenital agranulocytosis: prolonged survival and terminal acute leukemia. Blood 1970, 36:576-585.
57. de Planque MM, Bacigalupo A, Würsch A, Hows JM, Devergie A, Frickhofen N, Brand A, Nissen C: Long-term follow-up of severe aplastic anemia patients treated with antithymocyte globulin. Br J Haematol 1989, 73:121-126.
58. Russell N, Gratwohl A, Schmitz N: The place of blood stem cells in allogeneic transplantation. Br J Haematol 1996, 93:747-753.
59. Lane T: Allogeneic marrow reconstitution using peripheral blood stem cells: the dawn of a new era. Transfusion 1996, 36:585-589.
60. Körbling M, Przepiorka D, Gajewski J, Champlin RE, Chan KW: With first successful allogeneic transplantations of apheresis-derived hematopoietic progenitor cells reported, can the recruitment of volunteer matched, unrelated stem cell donors be expanded substantially [letter]?. Blood 1995, 86:1235.