Switch of osteonectin and osteopontin mRNA expression in the process of cartilage-to-bone transition during fracture repair

Acta Histochemica

Volumn 100, Issue 3, 1998, Pages 287-295

  Nakase, Takanobu ^a   Sugimoto, Mizuo ^a   Sato, Motohiko ^a   Kaneko, Motoharu ^a   Tomita, Tetsuya ^a   Sugamoto, Kazuomi ^a   Nomura, Shintaro ^a   Kitamura, Yukihiko ^a   Yoshikawa, Hideki ^b   Yasui, Natsuo ^a   Yonenobu, Kazuo ^a   Ochi, Takahiro ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

Cartilage to bone transition; Fracture healing; Gene expression; In situ hybridization; Osteocalcin; Osteonectin; Osteopontin

Indexed keywords

DIGOXIGENIN; MESSENGER RNA; OSTEONECTIN; OSTEOPONTIN; URIDINE TRIPHOSPHATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE; CARTILAGE; CONTROLLED STUDY; FRACTURE; GENE LOCATION; IN SITU HYBRIDIZATION; MINERALIZATION; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0031824342     PISSN: 00651281     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-1281(98)80015-9     Document Type: Article

References (20)

1. Bogumill G, and Schwamm H (1984) Fracture. In: Bogumill GP; Schwamm HA (Eds) Orthopaedic pathology. A synopsis with clinical and radiographic correction. Saunders, Philadelphia, pp 70-82
2. Boskey A (1989) Noncollagenous matrix proteins and their role in mineralization. Bone Miner 6: 111-123
3. Boskey A (1992) Mineral-matrix interactions in bone and cartilage. Clin Ortnop 281. 244-274
4. Celeste A, Rosen V, Buecker J, Kriz R, Wang E, and Wozney J (1986) Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J 5: 1885-1890
5. Craig A, Smith JJ, and Denhardt D (1989) Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. J Biol Chem 264: 9682-9689
6. Gerstenfeld LC, and Shapiro FD (1996) Expression of bone-specific genes by hypertrophic chondrocytes: implication of the complex functions of the hypertrophic chondrocyte during endochondral bone development. J Cell Biochem 62: 1-9
7. Harter L, Hruska K, and Duncan R (1995) Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation. Endocrinology 136: 528-535
8. Hirakawa K, Hirota S, Ikeda T, Yamaguchi A, Takemura T, Nagoshi J, Yoshiki S, Suda T, Kitamura Y, and Nomura S (1994) Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization. J Bone Miner Res 9: 1551-1557
9. Hirota S, Ito A, Morii E, Wanaka A, Tohyama M, Kitamura Y, and Nomura S (1992) Localization of mRNA for c-kit receptor and its ligand in the brain of adult rats: an analysis using in situ hybridization histochemistry. Mol Brain Res 15: 47-54
10. Ikeda T, Nomura S, Yamaguchi A, Suda T, and Yoshiki S (1992) In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections. J Histochem Cytochem 40: 1079-1088
11. Jingushi S, Joyce ME, and Bolander ME (1992) Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair. J Bone Miner Res 7: 1045-1055
12. Nakase T, Nomura S, Yoshikawa H, Hashimoto J, Hirota S, Kitamura Y, Oikawa S, Ono K, and Takaoka K (1994a) Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J Bone Miner Res 9: 651-659
13. Nakase T, Takaoka K, Hirakawa K, Hirota S, Takemura T, Onoue H, Takebayashi K, Kitamura Y, and Nomura S (1994b) Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Bone Miner 26: 109-122
14. Nomura S, Hashmi S, McVey J, Ham J, Parker M, and Hogan B (1989) Evidence for positive and negative regulatory elements in the 5′-flanking sequence of the mouse sparc (osteonectin) gene. J Biol Chem 264: 12201-12207
15. Owen T, Aronow M, Shalhoub V, Barone L, Wilming L, Tassinari M, Kennedy M, Pockwinse S, Lian J, and Stein G (1990) Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationship in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143: 420-430
16. Schenk R, and Hunziker E (1994) Histologic and ultrastructural features of fracture healing. In: Brighton CT, Friedlaender GT, Lane JM (Eds) Bone formation and repair. American Academy of Orthopaedic Surgens, Ilinois, pp 117-146
17. Sommer B, Bickel M, Hofstetter W, and Wetterwald A (1996) Expression of matrix proteins during the development of mineralized tissues. Bone 19: 371-380
18. Stanford C, Morcuende J, and Brand R (1995) Proliferative and phenotypic responses of bone-like cells to mechanical deformation. J Orthop Res 13: 664-670
19. Weber B, and Cech O (1976a) The healing of fractures. In: Weber BG, Cechn O (Eds) Pseudoarthrosis: Pathophysioloy, biomechanics, therapy, results. Huber Medical Publisher, Berne, pp 14-28
20. Weber B, and Cech O (1976b) Biological activity of bones in disturbed healing. The scintiscan. In: Weber BG, Cechn O (Eds) Pseudoarthrosis: Pathophysioloy, biomechanics, therapy, results. Huber Medical Publishers, Berne, pp 29-44