Development of an immunoassay for BMS-191352, a single-chain immunotoxin, and its application to toxicokinetic studies

Journal of Immunoassay

Volumn 19, Issue 2-3, 1998, Pages 145-165

  Damle, Bharat ^a   Hollenbaugh, Deborah ^b   Timoszyk, Julita ^b   Tay, Lee ^b   Kaul, Sanjeev ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b NONE

Author keywords

BMS 191352; ELISA; Immunotoxin; Toxicokinetics

Indexed keywords

IMMUNOTOXIN; PSEUDOMONAS EXOTOXIN;

ARTICLE; CYTOTOXICITY; DIAGNOSTIC VALUE; DOG; IMMUNOASSAY; NONHUMAN; TOXIN ANALYSIS;

EID: 0031823802     PISSN: 01971522     EISSN: None     Source Type: Journal    
DOI: 10.1080/01971529808005478     Document Type: Article

References (17)

1. Wawrzynczak, E. J. Systemic immunotoxin therapy of cancer: advances and prospects. Br. J. Cancer 1991; 64: 624-630.
2. Cobb P.W., LeMaistre C.F. Therapeutic use of immunotoxins. Semin. Oncol. 1992; 29(3): 6-13.
3. Frankel, A.E., FitzGerald, D., Siegall, C., Press, O.W. Advances in immunotoxin biology and therapy: a summary of the Fourth International Symposium on Immunotoxins. Cancer Res. 1996; 56(4): 926-932.
4. Friedman, P.N., McAndrew, S.J., Gawlak, S.L., Chace, D., Trail, P.A., Brown, J.P., and Siegall, C.B. BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells. Cancer Res. 1993; 53: 334-339.
5. Hellström, I., Garrigues, H.J., Garrigues, U., and Hellström, K.E. Highly tumor reactive, internalizing, mouse monoclonal antibodies to LeY-related cell-surfact antigens. Cancer Res. 1990; 50: 2183-2190.
6. Ogata, M., Chaudhary, V.K., Pastan, I., and FitzGerald, D.J., Processing of Pseudomonas exotoxin by a cellular protease results in generation of a 37,000 Da toxin fragment that is translocated to the cytosol. J. Biol. Chem. 1990; 265; 20678-20682.
7. Iglewski, B.H., Lui, P. V., Kabat, D. Mechanism of action of Pseudomonas aeruginosa exotoxin A; adenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect. Immun. 1977; 15: 38-44.
8. Siegall, C.B., Chaudhary, V.K., Fitzgerald, D.J., and Pastan, I. Functional analysis of domains II, Ib and III of Pseudomonas exotoxin. J. Biol. Chem. 1989; 264: 14256-14261.
9. Siegall, C.B., Chace, D., Mixan, B., Garrigues, U., Wan, H., Paul, L., Wolff, E., Hellström, I., Hellström, K.E. In vitro and in vivo characterization of BR96 sFv-PE40: A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats. J. Immunol. 1994; 152: 2377-2384.
10. Friedman, P.N., Chace, D., Trail, P., Siegall, C.B. Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts. J. Immunol. 1993; 150: 3054-3061.
11. DeLean, A., Munson, P. J., Rodbard, D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 1978; 235 (2): E97-E102.
12. Dixon, W.J., and Massey F.J. Introduction to statistical analysis. 4th ed. McGraw-Hill, New York, NY, 1983.
13. Neter, J., and Wasserman, W. Applied linear statistical methods. R. D. Irwin Inc.; 117-121.
14. Winer, B.J. Statistical Principles in Experimental Design. 2nd ed. McGraw-Hill; New York, NY, 1971.
15. Gibaldi, M., and Perner, D. Non-compartmental analysis based on statistical moment theory. In: Gibaldi M, Perrier D., ed. Pharmacokinetics. 2nd ed. New York: Marcel Dekker, 1982: 409-418.
16. SAS/STAT Users Guide; Version 6, 4th ed., SAS Institute Inc., Cary, NC, 1989.
17. Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm. Res. 1993; 10: 1093-1095.