High serum interleukin-6 levels correlate with a shorter failure-free survival in indolent lymphoma

Leukemia and Lymphoma

Volumn 30, Issue 5-6, 1998, Pages 563-571

  Fayad, Luis ^a   Cabanillas, Fernando ^a   Talpaz, Moshe ^a   Mclaughlin, Peter ^a   Kurzrock, Razelle ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Interleukin 6; Lymphoma; Prognostic factors

Indexed keywords

BETA 2 MICROGLOBULIN; BLEOMYCIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOKINE; DOXORUBICIN; ETOPOSIDE; INTERLEUKIN 6; METHOTREXATE; METHYLPREDNISOLONE SODIUM SUCCINATE; MITOXANTRONE; PREDNISONE; PROCARBAZINE; VINCRISTINE; VINCRISTINE SULFATE;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS;

EID: 0031822779     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057568     Document Type: Article

References (50)

1. Van Snick, J. (1990). Interleukin-6: An overview. Annu Rev Immunol, 8, 253-278.
2. Kishimoto, T. (1989). The biology of interleukin-6. Blood, 74, 1-10.
3. Heinrich, P. C., Catell, J. V. and Andus, T. (1990). Interleukin-6 and the acute phase response. Biochem J, 265, 621-636.
4. Yee, C. Y., Biondi, A., Wang, X. H., Iscovenn, N., de Sousa, J., Aarden, L. A., Wong, G. G., Clark, S. C., Messner, H. A. and Minden, M. D. (1989). A possible autcrine role for Interleukin-6 in two lymphoma cell lines. Blood, 74, 798-804.
5. Chang, H., Jamal, N., Wang, X.-H., Minden, M. D. and Messner, H. A. (1992). Constitutive production of the IL-5 and IL-6 by the lymphoma cell line OCI-Ly 17 derived from a patient with malignant lymphoma and hypereosinophilia. Leuk Lymphoma, 8, 97-107.
6. Takeshita, M., Sumiyoshi, Y., Masuda, Y., Ohshima, K., Yoshida, T., Kikuchi, M. and Muller, H. (1993). Cytokine (Interleukin-1 alpha, Interleukin-1 beta, tumor necrosis factor alpha, and Interleukin-6)-possessing cells in lymph nodes of malignant lymphoma. Pathol Res Pract, 189, 18-25.
7. Hsu, S.-M., Xie, S.-S. and Waldron, J. A., Jr. (1992). Functional heterogeneity and pathogenic significance of Interleukin-6 in B-cell lymphomas, Am J Pathol, 141, 915-923.
8. Freeman, G. J., Freeman, A. S., Rabinowe, S. N., Segil, J. M., Horowitz, J., Rosen, K., Whitman, J. M. and Nadler, L. M. (1989). Interleukin-6 gene expression in normal and neoplastic B cells. J Clin Invest, 83, 1512-1518.
9. Muller, H., Takeshita, M., Krause, J., Schuster, K., Kikushi, M. and Stutle, H. J. (1992). Immunohistochemical in situ demonstration of cytokines in Hodgkin's and non-Hodgkin's lymphoma. Verb Dtsch Ges Pathol, 76, 164-168.
10. Pluda, J. M., Venzon, D. J., Tosato, G., Lietzan, J., Wyvill, X., Nelson, D. L., Jaffe, E. S., Karp, J. E., Broder, S. and Yarchoan, R. (1993). Parameters affecting the development of non-Hodgkin's lymphoma in patients with severe immunodeficiency virus infection receiving antiretroviral therapy. J Clin Oncol, 11, 1099-1107.
11. Scala, G., Quinto, I., Ruocco, M. R., Arcucci, A., Mallardo, M., Laretto, P., Foresi, G. and Venuta, S. (1990). Expression of an exogenous interleukin-6 gene in human Epstein-Barr virus B cells confers growth advantage and tumorigenicity. J Exp Med, 172, 61-68.
12. Woodroofe, C., Muller, W. and Ruther, U. (1992). Long-term consequences of interleukin-6 overexpression in transgenic mice. DNA Cell Biol, 587-592.
13. Tosato, G., Jones, K., Breinig, M. K., McWilliams, H. P. and McKnight, J. L. C. (1993). Interleukin-6 production in post-transplant lymphoproliferative disease. J Clin Invest, 91, 2806-2814.
14. Seymour, J. F., Talpaz, M., Cabanillas, F., Wetzler, M. and Kurzrock, R. (1995). Serum Interleukin-6 levels correlate with prognosis in diffuse large-cell lymphoma. J Clin Oncol, 13, 575-582.
15. Preti, A. H., Cabanillas, F., Talpaz, M., Tucker, S., Seymour, J. and Kurzrock, R. Prognostic value of serum interleukin-6 in diffuse large cell lymphoma. Ann Int Med (In Press.)
16. Gause, A., Scholz, R., Klein, S., Jung, W., Diehl, B., Tesch, H., Hasenclever, D. and Pfreundschuh, M. (1991). Increased levels of circulating interleukin-6 in patients with Hodgkin's disease. Hematol Oncol, 9, 307-313.
17. Kurzrock, R., Redman, J., Cabanillas, F., Jones, D., Rothberg, J. and Talpaz, M. (1993). Serum interleukin-6 levels are elevated in lymphoma patients and correlate with survival in advanced Hodgkin's disease and with B symptoms. Cancer Res, 53, 2118-2122.
18. Seymour, J. F., Talpaz, M., Hagemeister, F. B., Cabanillas, F. and Kurzrock, R. (1997). Clinical correlates of elevated serum levels of interleukin-6 in patients with untreated Hodgkin's disease. Am J Med, 102, 21-28.
19. Blay, J. Y., Negrier, S., Combaret, V., Attali, S., Goillot, E., Merrouche, Y., Mercatello, A., Ravault, A., Tourani, J. M., Moskovtchenko, J. E., Philip, T. and Favrot, M. (1992). Serum levels of interleukin-6 as a prognostic factor in metastatic renal carcinoma. Cancer Res, 52, 3317-33322.
20. Twillie, D. A., Eisenberger, M. A., Carducce, M. A., Hseih, W.-S., Kim, W. Y. and Simons, J. W. (1995). Interleukin-6: A candidate mediator of human prostate cancer morbidity. Urology, 45, 542-549.
21. Berek, J. S., Chung, C., Kaldi, K., Watson, J. M., Knox, R. M. and Martinez-Maza, O. (1991). Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer. Am J Ob Gyn, 164, 1038-1043.
22. Ludwig, H., Nachbaur, D. M., Fritz, E., Krainer, M. and Huber, H. (1991). Interleukin-6 is a prognostic factor in multiple myeloma. Blood, 77, 1794-2795.
23. Nachbaur, D. M., Herold, M., Maneschg, A. and Huber, H. (1991). Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: Correlation with disease activity and other prognostic parameters. Ann Hematol, 62, 54-58.
24. Kaplan, EI. and Meier, P. (1958). Non-parametric estimation from incomplete observations. J AM Stat Assoc, 53, 457-481.
25. Gehan, E. A. (1965). A generalized Wilcoxon test for comparing arbitrary singly censored samples. Biometrika, 52, 203-223.
26. Snedecor, G. W. and Cochran, W. G. (1980). Statistical Methos. (7th ed.). (Iowa State University, Ames. IA).
27. Altman, D. G. (1991). Practical statistics for medical research, (1st ed.), (Chapman & Hall, London).
28. Horning, S. J. and Rosenberg, S. A. (1984). The natural history of untreated low-grade non-Hodgkin's lymphomas. N Engl J Med, 311, 1471-1475.
29. Rosenberg, S. A. (1977). Validity of Ann Arbor staging of the non-Hodgkin's lymphomas. Cancer Treat Rep, 61, 1023-1027.
30. Ciampi, A., Bush, R. S., Gospodarowitz, M. and Till, J. E. (1981). An approach to classifying prognostic factors related to survival: Experience for non-Hodgkin's lymphoma patient based on a series of 982 patients: 1967-1975. Cancer, 46, 621-627.
31. Gospodarowitz, M., Bush, R. S. and Brown, T. C. (1984). Prognostic factors in the nodular lymphomas: a multivariate analysis based on the Princess Margaret experience, Int J Radiat Oncol Biol Phys, 10, 489-497.
32. Steward, W., Crowther, D., McWilliam, L. J., Jones, J. M., Deakin, D. P., Todd, I. D., Blackledge, G., Wagstaff, J., Scarffe, J. H. and Harris, M. (1988). Maintenance chlorambucil after CVP in the management of advance stage, low grade histological type of non-Hodgkin's lymphoma. Cancer, 61, 441-447.
33. Rudders, R. A., Kaddis, M., Delellis, L. A. and Casey, H. Jr. (1979). Nodular non-Hodgkin's lymphoma: Factor influencing prognosis and indications for aggressive treatment. Cancer, 43, 1643-1651.
34. Bloomfield, C. D., McKenna, R. W. and Brunning, R. D. (1974). Significance of haematological parameters in the non-Hodgkin's malignant lymphomas. Cancer, 33, 870-879.
35. McLaughlin, P., Fuller, L. M., Velasquez, W. S., Butler, J. J., Hagemeister, F. B., Sullivan-Halley, J. A. and Dixon, D. O. (1987). Stage III follicular lymphoma: Durable remissions with a combined chemotherapy-radiotherapy regimen. J Clin Oncol, 5, 867-874.
36. Romaguera, J. E., McLaughlin, P., North, L., Dixon, D., Silvermintz, K. B., Garnsey, L. A., Velasquez, W. S., Hagemeister, F. B. and Cabanillas, F. (1991). Multivariate analysis of prognostic factors in stage IV follicular low-grade lymphomas: A risk model. J Clin Oncol, 9, 762-769.
37. Litam, P., Swan, P., Cabanillas, F., Tucker, S. L., McLaughlin, P., Hagemeister, F. B., Rodriguez, M. A. and Velusques, W. S. (1991). Prognostic value of serum b-2 microglobulin in low-grade lymphoma. Ann Int Med, 114, 855-860.
38. Rodgers, R., McLaughlin, P., Sullivan, J. and Cubanillas, F. (1983). Prognostic factors in stage IV nodular lymphoma. Proc Am Soc Clin Oncol, 2, 217 (abstr).
39. Stasi, R., Conforti, M., Del Poeta, G., Simone, M. D., Coppetelli, U., Tribalto, M., Cantonetti, M., Perrotti, A., Venditti, A. and Papa, G. (1992). Soluble factors levels in the initial staging of high-grade non-Hodgkin's lymphomas. Haematologica, 77, 18-21.
40. Yee, C., Sutcliffe, S., Messner, H. A. and Minden, M. D. (1992). Interleukin-6 levels in the plasma of patients with lymphoma. Leuk Lymphoma, 7, 123-129.
41. Stasi, R., Stipa, E., Masi, M., Oliva, F., Sciarra, A., Perrotti, A., Olivieri, M., Zaccari, G., Gandolfo, G. M., Galli, M., et al. (1993). Antiphospholipid antibodies: Prevalence, clinical significance and correlation to cytokine levels in acute myelogenous leukemia and non-Hodgkin's lymphoma. Thromb Haemost, 70, 568-572.
42. Emilie, D., Devergne, O., Raphael, M., Coumbaras, C. J. and Galanaud, D. (1992). Production of interleukin-6 in high-grade B lymphomas. Curr Top Microbiol Immunol, 182, 349-355.
43. Emilie, D., Coumbaras, J., Raphael, M., Devergne, O., Delechse, H. J., Gissebrecht, C., Michiels, J. F., Van Damme, J., Taga, T. and Kishimoto, T. (1992). Interleukin-6 production in high-grade B lymphomas. Correlation with the presence of malignant immunoblast in acquired immunodeficiency syndrome and in human immunodeficiency virus-seronegative patients. Blood, 80, 498-504.
44. Strassman, G., Fong, M., Kenney, J. S. and Jacob, C. O. (1992). Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest, 89, 1681-1684.
45. Black, K., Garrett, J. R. and Mundy, G. R. (1991). Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology, 128, 2657-2659.
46. Ni, K. and O'Neill, H. C. (1992). Proliferation of the BCL1 B cell lymphoma induced by IL-4 and IL-5 is dependent on IL-6 and GM-CSF. Immnunol Cell Biol, 70, 315-322.
47. Shimizu, S., Hirano, T., Yoshioka, R., Sugai, S., Matsuda, T., Taga, T., Kishimoto, T. and Konda, S. (1988). Interleukin-6 (B-cell stimulatory factor-2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3). Blood, 72, 1826-1828.
48. 2 interferon Involved. Proc Natl Acad Sci USA, 83, 8957-8961.
49. Dansky Ullmann, C., Sclom, J. and Greiner, J. W. (1993). In vitro regulation of carcinoembryonic antigen (CEA) and class I HLA expression in human colon xenografts by interleukin-6 (IL-6) and the possible role of intrinsic interferon-induction. Proc Am Assoc Cancer Res, 34, 454 (abstr 2710).
50. The International Non-Hodgkin's Lymphoma Prognostic Factor Project. (1993). A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med, 329, 987-994.