Stability of nonaqueous suspension formulations of plasma derived factor IX and recombinant human alpha interferon at elevated temperatures

Pharmaceutical Research

Volumn 15, Issue 7, 1998, Pages 1090-1095

  Knepp, Victoria M ^a   Muchnik, Anna ^a   Oldmark, Sofia ^a   Kalashnikova, Larisa ^a  

^a ALZA CORPORATION   (United States)

Author keywords

Alpha interferon; Factor IX; Nonaqueous suspension; Perfluorodecalin; Protein; Stability

Indexed keywords

BLOOD CLOTTING FACTOR 9; HYDROCARBON; MACROGOL 400; METHOXYFLURANE; OCTANOL; PERFLUOROTRIBUTYLAMINE; RECOMBINANT ALPHA INTERFERON; SOYBEAN OIL; TETRADECANE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG STABILITY; DRY POWDER; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLUBILITY; SUSPENSION; TEMPERATURE; THROMBOPLASTIN TIME; VESICULAR STOMATITIS VIRUS; WATER CONTENT;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; FACTOR IX; FLUOROCARBONS; HEAT; HUMANS; INTERFERON TYPE I, RECOMBINANT; POWDERS; SUSPENSIONS; VEHICLES;

EID: 0031822501     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011994514358     Document Type: Article

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