Is the single use of intraoperative 5-fluorouracil in filtering surgery for high-risk cases enough?

Eye (Basingstoke)

Volumn 12, Issue 3, 1998, Pages 374-378

  Watts, Patrick ^a   Karia, Niral ^a   McAllister, James ^a  

^a KING EDWARD VII HOSPITAL   (United Kingdom)

Author keywords

5 Fluorouracil; Trabeculectomy

Indexed keywords

FLUOROURACIL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; FILTERING OPERATION; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INTRAOCULAR DRUG ADMINISTRATION; INTRAOCULAR PRESSURE; MALE; REOPERATION; RISK FACTOR; TRABECULECTOMY; TREATMENT OUTCOME;

EID: 0031821191     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.1998.89     Document Type: Article

References (25)

1. Teng CC, Chi HH, Katzin HM. Histology and mechanism of filtering operations. Am J Ophthalmol 1959;47:16-34.
2. Addick EM, Quigley HA, Green WR, Robin AL. Histological characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol 1983;101:795-8.
3. Maumenee AE. External filtering operations for glaucoma: the mechanisms of function and failure. Trans Am Ophthalmol Soc 1960;58:319-28.
4. Skuta GL, Parrish RK. Wound healing in glaucoma filtering surgery. Surv Ophthalmol 1987;32:149-70.
5. Jampel HD, McGuigan LJB, Dunkelberger GR, et al. Cellular proliferation after experimental glaucoma filtering surgery. Arch OphthalmoI1988;106:89-94.
6. Hartzer M, Daily N, Blumenkranz MS. Ocular pharmacology of fluoropyrimidines: mechanism of action of 5FU. Invest Ophthalmol Vis Sci 1987;28(Suppl)75.
7. Lee DA, Tehrani ST, Kitada S. The effect of 5-fluorouracil and cytarabine on human fibroblasts from the Tenon’s capsule. Invest Ophthalmol Vis Sci 1990;31:1848-58.
8. Heuer DK, Parrish RK, Gressel MG, Hodapp E, Palmberg PF, Anderson D. 5-Fluorouracil and glaucoma filtering surgery. II. A pilot study. Ophthalmology 1984;91:384-94.
9. Rabowsky JH, Ruderman JM. Low-dose 5-fluorouracil and glaucoma filtering surgery. Ophthalmic Surg 1989;20:347-9.
10. Lee DA, Hersh P, Kersten D, Melamed S. Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. Ophthalmic Surg 1987;18:187-90.
11. Lanigan L, Sturmer J, Baez KA, Hitchings RA, Khaw PT. Single intraoperative applications of 5-fluorouracil during filtering surgery: early results. Br J OphthalmoI1994;78:33-7.
12. Heuer DK, Parrish RK, Gressel MG, Hodapp E, Desjardins DC, Skuta GL, et al. 5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study. Ophthalmology 1986;93:1537-46.
13. Cairns JE. Trabeculectomy. Am J Ophthalmol 1968;66:673-9.
14. The Fluorouracil Filtering Surgery Study Group. Fluorouracil Filtering Surgery Study: One year follow-up. Am J Ophthalmol 1989;108:625-35.
15. The Fluorouracil Filtering Surgery Study Group. Three-year follow-up of the Fluorouracil Filtering Surgery Study. Am J OphthalmoI 1993;115:82-92.
16. The Fluorouracil Filtering Surgery Study Group. Five-year follow-up of the Fluorouracil Filtering Surgery Study. Am J Ophthalmol 1996;121:349-66.
17. Mora JS, Nguyen N, Iwach AG, et al. Trabeculectomy with intraoperative sponge 5-fluorouracil. Ophthalmology 1996;103:963-70.
18. Singh K, Egbert P, Byrd S, et al. Trabeculectomy with intraoperative 5-fluorouracil vs mitomycin C. Am J Ophthalmol 1997;123:48-53.
19. Bell RWD, Habib NE, O’Brien C. Long-term results and complications after trabeculectomy with a single peroperative application of 5 FU. Eye 1997;11:663-71.
20. Khaw PT, Sherwood MB, Mackay SL, et al. Five minute treatments with fluorouracil, floxuridine and mitomycin have long term effects on human Tenon’s capsule fibroblasts. Arch Ophthalmol 1992;110:1150-4.
21. Ophir A, Ticho U. A randomised study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. Arch Ophthalmol 1992;110:1072-5.
22. Khaw PT, Doyle JW, Sherwood MB, Grierson I, Shultz G, McGorray S. Prolonged localised tissue effects from 5-minute exposures to fluorouracil and mitomycin C. Arch Ophthalmol 1993;111:263-7.
23. Kitazawa Y, Kawase K, Matsushita H, Minobe M. Trabeculectomy with mitomycin: a comparative study with fluorouracil. Arch Ophthalmol 1991;109:1693-8.
24. Smith MF, Sherwood MB, Doyle W, Khaw PT. Results of intraoperative 5-fluorouracil supplementation on trabeculectomy for open-angle glaucoma. Am J Ophthalmol 1992;114:737-41.
25. Ruderman JM, Welch DB, Smith MF, Shoch DE. A randomised study of 5-fluorouracil and filtering surgery. Am J Ophthalmol 1987;104:218.