Distinctive activated cellular subsets in colon from patients with Crohn's disease and ulcerative colitis

Scandinavian Journal of Gastroenterology

Volumn 33, Issue 7, 1998, Pages 743-748

  Elewaut, D ^a   De Keyser, F ^b   Cuvelier, C ^b   Lazarovits, A I ^b   Mielants, H ^b   Verbruggen, G ^b   Sas, S ^b   Devos, M ^b   Veys, E M ^b  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b NONE

Author keywords

Adhesion molecules; Inflammatory bowel disease; Interleukin 2; T cell activation

Indexed keywords

INTERLEUKIN 2;

ARTICLE; CROHN DISEASE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ULCERATIVE COLITIS;

BIOLOGICAL MARKERS; BIOPSY, NEEDLE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MALE; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0031820499     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365529850171693     Document Type: Article

References (38)

1. Brynskov J, Nielsen OH, Ahnfelt-Ronne I, Bendtzen K. Cytokines in inflammatory bowel disease. Scand J Gastroenterol 1992;27:897-906.
2. Pirzer U, Schonhaar A, Fleischer B, Hermann E, Meyer zum Buschenfelde KH. Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 1991;338:1238-9.
3. Brynskov J, Tvede N, Andersen CB, Vilien M. Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992;33:55-8.
4. Smith KA. Interleukin 2. Annu Rev Immunol 1984;2:319-33.
5. Robb RJ. Interleukin-2: the molecule and its function. Immunol Today 1984;5:203-9.
6. Matsuura T, West GA, Youngman KR, Klein JS, Fiocchi C. Immune activation genes in inflammatory bowel disease. Gastroenterology 1993;104:448-58.
7. Choy MY, Walker-Smith JA, Williams CB, MacDonald TT. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990;31:1365-70.
8. Schreiber S, MacDermott RP, Raedler A, Pinnau R, Bertovich MJ, Nash GS. Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease. Gastroenterology 1991;101:1020-30.
9. Kirman I, Nielsen OH, Kjaersgaard E, Brynskov J. Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease. Dig Dis Sci 1995;40:291-5.
10. Picker LJ. Control of lymphocyte homing. Curr Opin Immunol 1994;6:394-406.
11. Schurmann GM, Bishop AE, Facer P, Vecchio M, Lee JC, Rampton DS, et al. Increased expression of cell adhesion molecule P-selectin in active inflammatory bowel disease. Gut 1995;36:411-8.
12. Koizumi M, King N, Lobb R, Benjamin C, Podolsky DK. Expression of vascular adhesion molecules in inflammatory bowel disease. Gastroenterology 1992;103:840-7.
13. Pooley N, Ghosh L, Sharon P. Up-regulation of E-selectin and intercellular adhesion molecule-1 differs between Crohn's disease and ulcerative colitis. Dig Dis Sci 1995;40:219-25.
14. Taylor PM, Rose ML, Yacoub MH, Pigott R. Induction of vascular adhesion molecules during rejection of human cardiac allografts. Transplantation 1992;54:451-7.
15. Suzuki Y, Ohtani H, Mizoi T, Takeha S, Shiiba K, Matsuno S, et al. Cell adhesion molecule expression by vascular endothelial cells as an immune/inflammatory reaction in human colon carcinoma. Jpn J Cancer Res 1995;86:585-93.
16. Burgio VL, Fais S, Boirivant M, Perrone A, Pallone F. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 1995;109:1029-38.
17. Rugtveit J, Brandtzaeg P, Halstensen TS, Hausa O, Scott H. Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut 1994;35:669-74.
18. Grimm MC, Pullman WE, Bennett GM, Sullivan PJ, Pavli P, Doe WF. Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa. J Gastroenterol Hepatol 1995;10: 387-95.
19. Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, New man W, et al. CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med 1992;176:245-53.
20. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185-5.
21. Strauch UG, Lifka A, Gosslar U, Kilshaw PJ, Clements J, Holzmann B. Distinct binding specificities of integrins alpha 4 beta 7 (LPAM-1), alpha4 beta 1 (VLA-4), and alpha IEL beta 7. Int Immunol 1994;6:263-75.
22. Briskin MJ, McEvoy LM, Butcher EC. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 1993;363:461-1.
23. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher HC. A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature 1988;331:41-6.
24. Kruschwitz M, Fritzsche G, Schwarting R, Micklem K, Mason DY, Falini B, et al. Ber-ACT8: new monoclonal antibody to the mucosa lymphocyte antigen. J Clin Pathol 1991;44:636-45.
25. Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature 1994;372:190-3.
26. Wagner N, Lohler J, Kunkel EJ, Ley K, Leung E, Krissansen G, et al. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996;382:366-70.
27. Hesterberg PE, Winsor-Hines D, Briskin MJ, Soler-Ferran D, Merrill C, Mackay CR, et al. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Gastroenterology 1996;111:1373-80.
28. high CD4+ T cells. J Immunol 1997;158:2099-106.
29. Yacyshyn BR, Lazarovits A, Tsai V, Matejko K. Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. Gastroenterology 1994; 107:1364-71.
30. Meenan J, Spaans J, Grool TA, Pals ST, Tytgat GN, van Deventer SJ. Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. Gut 1997;40:241-6.
31. Rosenberg WM, Prince C, Kaklamanis L, Fox SB, Jackson DG, Siminons DL, et al. Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease. Lancet 1995;345:1205-9.
32. Hernandez-Caselles T, Martinez-Esparza M, Lazarovits AI, Aparicio P. Specific regulation of VLA-4 and alpha 4 beta 7 integrin expression on human activated T lymphocytes. J Immunol 1996;156:3668-77.
33. Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996;110: 975-84.
34. Austrup F, Rebstock S, Kilshaw PJ, Hamann A. Transforming growth factor-beta 1-induced expression of the mucosa-related integrin alpha E on lymphocytes is not associated with mucosa-specific homing. Eur J Immunol 1995;25:1487-91.
35. Ellis TM, Simms PE, Slivnick DJ, Jack HM, Fisher RI. CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells. J Immunol 1993;151:2380-9.
36. Del Prete G, De Carli M, Almerigogna F, Daniel CK, D'Elios MM, Zancuoghi G, et al. Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB J 1995;9:81-6.
37. Del Prete G, De Carli M, D'Elios MM, Daniel KC, Almerigogna F, Alderson M, et al. CD30-mediated signaling promotes the development of human T helper type 2-like T cells. J Exp Med 1995;182:16.55-61.
38. Kanegane H, Kasahara Y, Niida Y, Yachie A, Sughii S, Takatsu K, et al. Expression of L-selectin (CD62L) discriminates Th1- and Th2-like cytokine-producing memory CD4+ T cells. Immunology 1996;87:186-90.