Monitoring of proteinuria in phase I studies in healthy male subjects

European Journal of Clinical Pharmacology

Volumn 54, Issue 4, 1998, Pages 287-294

  Lemm, G ^a   Kuppers J ^a   Frey, R ^a   Wingender, W ^a   Kuhlmann, J ^a  

^a Institute of Clinical Pharmacology   (Germany)

Author keywords

1 Microglobulin; Albuminuria; Drug development; N Acetyl glucosaminidase; Nephrotoxicity; Proteinuria

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; DRUG; MARKER; N ACETYL BETA GLUCOSAMINIDASE; PROTEIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; HUMAN; KIDNEY FUNCTION; MALE; NEPHROTOXICITY; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEINURIA;

ACETYLGLUCOSAMINIDASE; ADULT; ALBUMINURIA; ALPHA-GLOBULINS; CREATININE; CROSS-OVER STUDIES; EXERTION; HUMANS; MALE; PROSPECTIVE STUDIES; PROTEINURIA; REFERENCE VALUES; RETROSPECTIVE STUDIES;

EID: 0031818473     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050461     Document Type: Article

References (25)

1. Hofmann W, Regenbogen C, Edel H, Guder WG (1994) Diagnostic strategies in urinalysis. Kidney Int 46 [Suppl 47]: 111-114
2. Olivarius ND, Morgensen CE (1995) Danish general-practitioners' estimation of urinary albumin concentration in the detection of proteinuria and microalbuminuria. Br J Gen Pract 45: 71-73
3. Morgan DB, Dillon S, Payne RB (1978) The assessment of glomerular function: creatinine clearance or plasma creatinine? Postgrad Med J 54: 302-310
4. Viberti G, Hill RD, Jarrett RJ, Argyropoulos A, Marmud U, Keen H (1982) Microalbuminuria as a predictor of clinical nephropathy in insulin dependent diabetes mellitus. Lancet i: 1430-1432
5. Ritz E, Nowicki M, Fliser D, Horner D, Klimm HD (1994) Proteinuria and hypertension. Kidney Int 46 [Suppl 47]: 876-880
6. 1Microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. Eur J Clin Chem Clin Biochem 30: 683-691
7. Maruhn D (1976) Rapid colorimetric assay of β-galactosidase and N-acetyl-β-glucosaminidase in human urine. Clin Chim Acta 73: 453-461
8. Hofmann W, Guder WG (1989) A diagnostic program for quantitative analysis of proteinuria. J Clin Chem Clin Biochem 27: 589-600
9. Price RG (1982) Urinary enzymes, nephrotoxicity and renal disease. Toxicology 23: 99-134
10. Wellwood JM, Price RG, Ellis BG, Thompson AE (1976) A note on the practical aspects of the assay of N-acetyl-β-glucosaminidase in human urine. Clin Chim Acta 69: 85-91
11. Maruhn D, Fuchs D, Mues G, Bock KD (1976) Normal limits of urinary excretion of eleven enzymes. Clin Chem 22: 1567-1574
12. 2-microglobulin and retinol binding protein in urine. Clin Chim Acta 179: 73-78
13. Teppo AM (1982) Immunoturbidimetry of albumin and immunoglobulin G in urine. Clin Chem 28: 1359-1361
14. Hallbach J, Poppe W, Guder WG (1985) An automated procedure to measure N-acetyl-β-D-glucosaminidase in urine. (abstract) J Clin Chem Clin Biochem 23: 590
15. Ivandic M, Hofmann W, Guder WG (1996) Development and evaluation of a urine protein expert system. Clin Chem 42: 1214-1222
16. Kuhlmann J, Seidel G, Grötsch H, Richter E, Seeger K (1982) Comparative studies of nephrotoxicity of antibiotic combinations with tobramycin, cefotaxime and azlocillin in man. Drugs Exp Clin Res 8: 137-148
17. Deslypere JP, Delanghe J, Vermeulen A (1990) Proteinuria as a complication of simvastatin treatment. Lancet 336: 1453
18. Wiesmann U, Peheim E, Colombo JP (1989) Excretion of N-acetyl-β-D-glucosaminidase in urine of children with type I diabetes and of patients treated with amikacin. Klin Wochenshr 67 [Suppl XVII]: 40-43
19. Maruhn D, Strozyk K, Gielow L, Bock KD (1977) Diurnal variations of urinary enzyme excretion. Clin Chim Acta 75: 427-433
20. Werner M, Heilhron DC, Maruhn D, Aloha M (1970) Patterns of urinary enzyme excretion in healthy subjects. Clin Chim Acta 29: 437-449
21. Romanelli G, Giustina A, Bossoni S, Caldonazzo A, Cimino A, Cravarezza P, Giustina G (1990) Short-term administration of captopril and nifedipine and exercise-induced albuminuria in normotensive diabetic patients with early-stage nephropathy. Diabetes 39: 1333-1338
22. Burchardt U, Jung K (1992) Physiological factors influencing enzyme excretion. In: Jung K, Mattenheimer H, Burchardt U (eds) Urinary enzymes. Springer, Berlin Heidelberg New York, pp 73-86
23. Scherberich JE, Mösbauer A, Meissner A, Bentele D, Schoeppe B, Schoeppe W (1989) Kidney-and serum derived proteins in urine of patients suffering from renal diseases or arterial hypertension. Klin Wochenschr 67 [Suppl XVII]: 44-47
24. Weber MH, Verwiebe R, Janning G, Scheler F (1989) Application of urinary indicator proteins in the non-invasive assessment of glomerulo-tubular lesions in patients with chronic glomerulonephritis and rheumatoid arthritis. Klin Wochenschr 67 [Suppl XVII]: 48-51
25. 1-microglobulin in urine. Clin Chim Acta 206: 245-247