Novel 3'-spiro nucleoside analogues of TSAO-T. Part II. A comparative study based on NMR conformational analysis in solution and theoretical calculations

Antiviral Chemistry and Chemotherapy

Volumn 9, Issue 4, 1998, Pages 333-340

  Alvarez, R ^a   Jimeno, M L ^a   Gago, F ^b   Balzarini, J ^c   Perez Perez M J ^a   Camarasa, M J ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

3' spironucleosides; AIDS; HIV; Non nucleoside HIV 1 RT inhibitors; TSAO T

Indexed keywords

[1 [2',5' BIS O (TERT BUTYL DIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL]THYMINE] 3' SPIRO 5'' (4'' AMINO 1'',2'',3'' OXATHIAZOLE 2'',2'' DIOXIDE); [1 [2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL]THYMINE] 3' SPIRO 5'' (4'' AMINO 1'',2'' OXATHIOLE 2'',2'' DIOXIDE); [1 [2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL]THYMINE] 3' SPIRO 5'' (4'' AMINO 2'' OXAZOLONE); ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE INHIBITOR; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; COMPARATIVE STUDY; COMPUTER PROGRAM; DRUG CONFORMATION; ELECTRIC POTENTIAL; HUMAN IMMUNODEFICIENCY VIRUS; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SOLVATION; STRUCTURE ANALYSIS;

ANTI-HIV AGENTS; ELECTROSTATICS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; SPIRO COMPOUNDS; THYMIDINE;

EID: 0031818269     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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