Site-specific effect of radical scavengers on the resistance of low density lipoprotein to copper-mediated oxidative stress: Influence of α-tocopherol and temperature

Chemistry and Physics of Lipids

Volumn 92, Issue 2, 1998, Pages 139-149

  Gallová, Jana ^a,b   Abuja, Peter M ^c   Pregetter, Magdalena ^a   Laggner, Peter ^a   Prassl, Ruth ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b Faculty of Natural Sciences   (Slovakia)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Conjugated diene formation; Copper mediated oxidation; EPR spectroscopy; Spin labels

Indexed keywords

ALPHA TOCOPHEROL; COPPER; LOW DENSITY LIPOPROTEIN; NITROXIDE; SCAVENGER;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

COPPER; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HUMANS; KINETICS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; OXIDATIVE STRESS; SPIN LABELS; TEMPERATURE; VITAMIN E;

EID: 0031817572     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(98)00017-6     Document Type: Article

References (46)

1. Abuja P.M., Albertini R., Esterbauer H. Simulation of the induction of oxidation of low-density lipoprotein by high copper concentrations: evidence for a nonconstant rate of initiation. Chem. Res. Toxicol. 10:1997;644-651.
2. Abuja P.M., Esterbauer H. Simulation of lipid peroxidation in low-density lipoprotein by a basic 'skeleton' of reactions. Chem. Res. Toxicol. 8:1995;753-763.
3. Bales B.L., Lesin E.S., Oppenheimer S.B. On cell membrane lipid fluidity and plant lectin agglutinability. a spin label study of mouse ascites tumor cells. Biochim. Biophys. Acta. 465:1977;400-407.
4. Berliner J.A., Heinecke J.W. The role of oxidized lipoproteins in atherogenesis. Free Rad. Biol. Med. 20:1996;707-727.
5. Bowry V.W., Ingold K.U., Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem. J. 288:1992;341-344.
6. Bowry V.W., Mohr D., Cleary J., Stocker R. Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein. J. Biol. Chem. 270:1995;5756-5763.
7. Bowry V.W., Stocker R. Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115:1993;6029-6044.
8. Deckelbaum R.J., Shipley G.G., Small D.M. Structure and interactions of lipids in human plasma low density lipoproteins. J. Biol. Chem. 252:1977;744-754.
9. Dieber-Rotheneder M., Puhl H., Waeg G., Striegl G., Esterbauer H. Effect of oral supplementation with D-alpha-tocopherol on the vitamin-E content of human low-density lipoproteins and resistance to oxidation. J. Lipid Res. 32:1991;1325-1332.
10. Esterbauer H., Rotheneder M., Striegl G., Waeg G., Ashly A., Sattler W., Jürgens G. Vitamin E and other lipophilic antioxidants protect LDL against oxidation. Fat Sci. Technol. 91:1989;316-324.
11. Esterbauer H., Gebicki J., Puhl H., Jürgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad. Biol. Med. 13:1992;341-390.
12. Esterbauer H., Puhl H., Waeg G. et al. The role of vitamin E in lipoprotein oxidation. Packer L., Fuchs J. Vitamin E in Health and Disease. 1992;649-671 Marcel Dekker, New York.
13. 31P NMR study. Biochemistry. 29:1990;3973-3981.
14. Gieseg S.P., Esterbauer H. Low density lipoprotein is saturable by pro-oxidant copper. FEBS Lett. 343:1994;188-194.
15. Gotoh N., Noguchi N., Tsuchiya J., Morita K., Sakai H., Shimasaki H., Niki E. Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds. Free Rad. Res. 24:1996;123-134.
16. Gutteridge J.M.C., Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. TIBS. 15:1990;129-135.
17. Halliwell B. How to characterize a biological antioxidant. Free Rad. Res. Commun. 9:1990;1-32.
18. Hoff H.F., O'Neil J. Lesion-derived low-density-lipoprotein and oxidized low-density-lipoprotein share a lability for aggregation. Leading to enhanced macrophage degradation. Arterioscler. Thromb. 11:1991;1209-1222.
19. Hubbell W.L., McConnell H.M. Molecular motion in spin-labeled phospholipids and membranes. J. Am. Chem. Soc. 93:1971;314-325.
20. Kalyanaraman B., Joseph J., Parthasarathy S. The spin trap, α-phenyl N-tert-butylnitrone inhibits the oxidative modification of low-density lipoprotein. FEBS Lett. 280:1991;17-20.
21. Kalyanaraman B., Joseph J., Parthasarathy S. Site-specific trapping of reactive species in low-density lipoprotein oxidation: biological implications. Biochim. Biophys. Acta. 1168:1993;220-227.
22. Kontush A., Meyer S., Finckh B., Kohlschutter A., Beisiegel U. Alpha-tocopherol as a reductant for Cu (II) in human lipoproteins - triggering role in the initiation of lipoprotein oxidation. J. Biol. Chem. 271:1996;11106-11112.
23. Kveder M., Pifat G., Pecar S., Schara M. The ESR characterization of molecular mobility in the lipid surface layer of human serum lipoproteins. Chem. Phys. Lipids. 70:1994;101-108.
24. Kveder M., Pifat G., Pecar S., Schara M., Ramos P., Esterbauer H. Nitroxide reduction with ascorbic acid in spin labeled human plasma LDL and VLDL. Chem. Phys. Lipids. 85:1997;1-12.
25. Laggner P., Kostner G.M. Thermotropic changes in the surface structure of lipoprotein B from human-plasma low-density lipoproteins. A spin-label study. Eur. J. Biochem. 84:1978;227-232.
26. Laggner P., Kostner G.M., Degovics G., Worcester D.L. Structure of the cholesteryl ester core of human plasma low density lipoproteins: Selective deuteration and neutron small-angle scattering. Proc. Natl. Acad. Sci. USA. 81:1984;4389-4393.
27. Laggner P., Kostner G.M., Rakusch U., Worcester D.L. Neutron small-angle scattering on selectively deuterated human plasma low density lipoproteins. The location of polar phospholipid headgroups. J. Biol. Chem. 256:1981;11832-11839.
28. Lynch S.M., Frei B. Reduction of copper, but not iron by human low density lipoprotein (LDL)-implications for metal ion-dependent oxidative modification of LDL. J. Biol. Chem. 270:1995;5158-5163.
29. Neuzil J., Thomas S.R., Stocker R. Requirement for, promotion or inhibition by alpha-tocopherol of radical-induced initiation of plasma-lipoprotein lipid-peroxidation. Free Rad. Biol. Med. 22:1997;57-71.
30. Puhl H., Waeg G., Esterbauer H. Methods to determine oxidation of low-density lipoproteins. Methods Enzymol. 233:1994;425-441.
31. Puhl H., Waeg G., Tatzber F. et al. Effect of vitamin E and other antioxidants on the oxidation resistance of human low density lipoproteins. Poli G., Albano E., Dianzani M.U. Free Radicals: From Basic Science to Medicine. 1993;479-489 Birkhäuser Verlag, Basel.
32. Ramos P., Gieseg S.P., Schuster B., Esterbauer H. Effect of temperature and phase transition on oxidation resistance of low density lipoprotein. J. Lipid Res. 36:1995;2113-2128.
33. Rumsey S.C., Galeano N.F., Arad Y., Deckelbaum R.J. Cryopreservation with sucrose maintains normal physical and biological properties of human plasma low-density lipoproteins. J. Lipid Res. 33:1992;1551-1561.
34. Rumsey S.C., Stucchi A.F., Nicolosi R.J., Ginsberg H.N., Ramakrishnan R., Deckelbaum R.J. Human plasma LDL cryopreserved with sucrose maintains in-vivo kinetics indistinguishable from freshly isolated human LDL in cynomolgus monkeys. J. Lipid Res. 35:1994;1592-1598.
35. Sato Y., Kamo S., Takahashi T., Suzuki Y. Mechanism of free radical-induced hemolysis of human erythrocytes: hemolysi by water-soluble radical initiator. Biochemistry. 34:1995;8940-8948.
36. Sattler W., Kostner G.M., Waeg G., Esterbauer H. Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins. Biochim. Biophys. Acta. 1081:1991;65-74.
37. Schuster B., Prassl R., Nigon F., Chapman M.J., Laggner P. Core lipid structure is a major determinant of the oxidative resistance of low density lipoprotein. Proc. Natl. Acad. Sci. USA. 92:1995;2509-2513.
38. Singh S., Suri R., Agrawal C.G. Fluorescence properties of oxidised human plasma low-density lipoproteins. Biochim. Biophys. Acta. 1254:1995;135-139.
39. Steinberg D., Parthasarathy S., Carew S., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. New Engl. J. Med. 320:1989;915-924.
40. Steinbrecher U.P., Lougheed M. Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima. Arterioscler. Thromb. 12:1992;608-625.
41. Steinbrecher U.P., Parthasarathy S., Leake D.S., Witztum J.L., Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA. 81:1984;3883-3887.
42. Takahashi M., Tsuchiya J., Niki E. Scavenging of radicals by vitamin E in the membranes as studied by spin labeling. J. Am. Chem. Soc. 111:1989;6350-6353.
43. Waldeck A.R., Stocker R. Radical-initiated lipid peroxidation in low density lipoproteins: insights obtained from kinetic modeling. Chem. Res. Toxicol. 9:1996;954-9641.
44. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88:1991;1785-1792.
45. Ylä-Herttuala S. Macrophages and oxidized low density lipoproteins in the pathogenesis of atherosclerosis. Ann. Med. 23:1991;561-567.
46. Yoshida Y., Kashiba K., Niki E. Free radical-mediated oxidation of lipids induced by hemoglobin in aqueous dispersions. Biochim. Biophys. Acta. 1201:1994;165-172.