Deficits in smooth-pursuit eye movements after muscimol inactivation within the primate's frontal eye field

Journal of Neurophysiology

Volumn 80, Issue 1, 1998, Pages 458-464

  Shi, Dexiu ^a   Friedman, Harriet R ^a   Bruce, Charles J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; MUSCIMOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EYE FUNDUS; MACACA; NONHUMAN; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SMOOTH PURSUIT EYE MOVEMENT; VELOCITY;

EID: 0031816697     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.1.458     Document Type: Article

References (30)

1. BRUCE, C. J. Integration of sensory and motor signals for saccadic eye movements in the primate frontal eye fields. In: Signal and Sense, Local and Global Order in Perceptual Maps, edited by G. M. Edelman, W. E. Gall, and W. M. Cowan. New York: Wiley-Liss, 1990, p. 261-314.
2. BRUCE, C. J., GOLDBERG, M. E., BUSHNELL, M. C., AND STANTON, G. B. Primate frontal eye fields. II. Physiological and anatomic correlates of electrically evoked eye movements. J. Neurophysiol. 54: 714-734, 1985.
3. CRIST, C. F., YAMASAKI, D.S.G., KOMATSU, H., AND WURTZ, R. H. A grid system and a microsyringe for single cell recording. J. Neurosci. Methods 26: 117-122, 1988.
4. DIAS, E. C., KIESAU, M., AND SEGRAVES, M. A. Acute activation and inactivation of macaque frontal eye field with GABA-related drugs. J. Neurophysiol. 74: 2744-2748, 1995.
5. GOLDMAN-RAKIC, P. S. AND SELEMON, L. D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr. Bull. 23: 437-458, 1997.
6. GOTTLIEB, J. P., BRUCE, C. J., AND MACAVOY, M. G. Smooth eye movements elicited by microstimulation in the primate frontal eye field. J. Neurophysiol. 69: 786-799, 1993.
7. GOTTLIEB, J. P., MACAVOY, M. G., AND BRUCE, C. J. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field. J. Neurophysiol. 72: 1634-1653, 1994.
8. HUERTA, M. F., KRUBITZER, L. A., AND KAAS, J. H. Frontal eye field as defined by intracortical microstimulation in squirrel monkeys, owl monkeys, and macaque monkeys: I. Subcortical connections. J. Comp. Neurol. 253: 415-439, 1986.
9. KEATING, E. G. Frontal eye field lesions impair predictive and visually-guided pursuit eye movements. Exp. Brain Res. 86: 311-323, 1991.
10. KEATING, E. G. Lesions of the frontal eye field impair pursuit eye movements, but preserve the predictions driving them. Behav. Brain Res. 53: 91-104, 1993.
11. KEATING, E. G., PIERRE, A., AND CHOPRA, S. Ablation of the pursuit area in the frontal cortex of the primate degrades foveal but not optokinetic smooth eye movements. J. Neurophysiol. 76: 637-641, 1996.
12. KRAUZLIS, R. J. Pursuit eye movements. In: Handbook of Brain Theory and Neural Networks, edited by M. A. Arbib. Cambridge, MA: MIT Press, 1995, p. 775-779.
13. KRAUZLIS, R. J. AND LISBERGER, S. G. A model of visually-guided smooth pursuit eye movements based on behavioral observations. J. Comp. Neurosci. 1: 265-283, 1994.
14. LEVIN, S. Frontal lobe dysfunctions in schizophrenia - I. Eye movement impairments. J. Psychiatr. Res. 18: 27-55, 1984.
15. LEVIN, S., LUEBKE, A., ZEE, D. S., HAIN, T. C., ROBINSON, D. A., AND HOLZMAN, P. S. Smooth pursuit eye movements in schizophrenics: quantitative measurements with the search-coil technique. J. Psychiatr. Res. 22: 195-206, 1988.
16. LEVY, D. L., HOLZMAN, P. S., MATTHYSSE, S., AND MENDELL, N. R. Eye tracking and schizophrenia: a selective review. Schizophr. Bull. 20: 47-62, 1994.
17. LYNCH, J. C. Frontal eye field lesions in monkeys disrupt visual pursuit. Exp. Brain Res. 68: 437-441, 1987.
18. MACAVOY, M. G. AND BRUCE, C. J. Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions. Int. J. Neurosci. 80: 117-151, 1995.
19. MACAVOY, M. G., GOTTLIEB, J. P., AND BRUCE, C. J. Smooth-pursuit eye movement representation in the primate frontal eye field. Cereb. Cortex 1: 95-102, 1991.
20. MAY, J. G., KELLER, E. L., AND SUZUKI, D. A. Smooth-pursuit eye movement deficits with chemical lesions in the dorsolateral pontine nucleus of the monkey. J. Neurophysiol. 59: 952-977, 1988.
21. PETIT, L., CLARK, V. P., INGEHOLM, J., AND HAXBY, J. V. Dissociation of saccade-related and pursuit-related activation in human frontal eye fields as revealed by fMRI. J. Neurophysiol. 77: 3386-3390, 1997.
22. ROBINSON, F. R., STRAUBE, A., AND FUCHS, A. F. Participation of caudal fastigial nucleus in smooth pursuit eye movements. II. Effects of muscimol inactivation. J. Neurophysiol. 78: 848-859, 1997.
23. SHI, D., FRIEDMAN, H. R., AND BRUCE, C. J. Frontal eye field activity in conjunction with saccades made in response to step-ramp motion. Soc. Neurosci. Abstr. 21: 1195, 1995.
24. SHI, D., FRIEDMAN, H. R., AND BRUCE, C. J. Frontal eye field visual activity preceding saccades to moving targets. Soc. Neurosci. Abstr. 22: 418, 1996.
25. SHI, D., FRIEDMAN, H. R., AND BRUCE, C. J. Deficits in smooth-pursuit eye movements from muscimol injection in the primate frontal eye field. Soc. Neurosci. Abstr. 23: 473, 1997.
26. SOMMER, M. A. AND TEHOVNIK, E. J. Reversible inactivation of macaque frontal eye field. Exp. Brain Res. 116: 229-249, 1997.
27. STANTON, G. B., DENG, S.-Y., GOLDBERG, M. E., AND MCMULLEN, N. T. Cytoarchitectural characteristic of the frontal eye fields in macaque monkeys. J. Comp. Neurol. 282: 415-427, 1989.
28. STANTON, G. B., GOLDBERG, M. E., AND BRUCE, C. J. Frontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and pons. J. Comp. Neurol. 271: 493-506, 1988.
29. SWEENEY, J. A., LUNA, B., STROJWAS, M. H., AND THULBORN, K. R. Mapping distinct cortical eye fields for saccades and pursuit eye movements in humans using fMRI. Soc. Neurosci. Abstr. 23: 2222, 1997.
30. WEINBERGER, D. R. AND BERMAN, K. F. Prefrontal function in schizophrenia: confounds and controversies. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351: 1495-1503, 1996.