Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis

British Journal of Cancer

Volumn 78, Issue 3, 1998, Pages 312-320

  Joseph, P ^a   Klein Szanto, A J P ^b   Jaiswal, A K ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

Carcinogenesis; Cellular transformation; Hydroquinone; Mutagenesis; NAD(P)H:quinone oxidoreductase 1 (DT diaphorase); Tumorigenesis

Indexed keywords

BENZENE; BENZO[A]PYRENE; CARCINOGEN; HYDROQUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSFER RNA;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL FREE SYSTEM; CELL TRANSFORMATION; CHO CELL; DNA SEQUENCE; EMBRYO; ESCHERICHIA COLI; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; KIDNEY CELL; MONOLAYER CULTURE; MUTAGENESIS; NONHUMAN; PLASMID; PRIORITY JOURNAL;

EID: 0031814671     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.492     Document Type: Article

References (29)

1. Balmain A and Brown K (1988) Oncogene activation in chemical carcinogenesis. Adv Cancer Res 51: 147-182
2. Beroud C, Verdier F and Soussi T (1996) p53 gene mutation: software and database. Nucl Acids Res 24: 147-150
3. Cadenas E (1995) Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism. Biochem Pharm 49: 127-140
4. Chesis PL, Levin DE, Smith MT, Ernster L and Ames BN (1984) Mutagenicity of quinones: pathways of metabolic activation and detoxification. Proc. Natl Acad Sci USA 81: 1696-1700
5. Colapietro A, Goodell AL and Smart RC (1993) Characterization of benzo(a)pyrene-induced mouse skin papillomas for Ha-ras mutations and protein kinase C levels. Carcinogenesis 14: 2289-2295
6. Gelboin HV (1980) Benzo(a)pyrene metabolism, activation and carcinogenesis: role and regulation of mixed function oxidases and related enzymes. Physiol Rev 60: 1107-1166
7. Goodrow TL, Storer RD, Leander KR, Prahalada SR, Van Zwieten MJ and Bradley MO (1992) Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors. Molecular Carcinogen 5: 9-15
8. Harris CC (1991) Physical and chemical carcinogenesis: advances and perspectives for the 1990s. Cancer Res 51: 5023s-5044s
9. Hiraku Y and Kawanishi S (1996) Oxidative DNA damage and apoptosis induced by benzene metabolites. Cancer Res 56: 5172-5178
10. Hollstein M, Sidransky D, Vogelstein B and Harris CC (1991) p53 mutations in human cancers. Science 253: 49-53
11. Jaiswal AK (1994) Antioxidant response element. Biochem. Pharmacol 48: 439-444
12. Jaiswal AK, McBride OW, Adensik M and Nebert DW (1988) Human dioxin-inducible cytosolic NAD(P)H:Quinone Oxidoreductase, J Biol Chem 263: 13572-13578
13. Jernstrom B and Graslund A (1994) Covalent binding of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: molecular structures, induced mutations and biological consequences. Biophys Chem 49: 185-199
14. Joseph P and Jaiswal AK (1994) NAD(P)H:quinone oxidoreductasel (DT diaphorase) specifically prevents the formation of benzo(a)pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase. Proc Natl Acad Sci USA 91: 8413-8417
15. Joseph P, Xie T, Xu YH and Jaiswal AK (1994) NAD(P)H:quinone oxidoreductase 1 (DT-diaphorase): expression, regulation, and role in cancer. Oncol Res 6: 525-532
16. Kaufman RJ, Davies MV, Wasley LC and Michnick D (1991) Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucl Acids Res 19: 4485-4490
17. Kraemer KH and Seidman MM (1989) Use of supF, an Escherichia coli tyrosine suppressor tRNA gene, as a mutagenic target in shuttle-vector plasmids. Mutation Res 220: 61-72
18. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R and Berns A (1991) Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19: 4293
19. Lind C, Hochstein P and Ernster L (1982) DT-Diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation Arch Biochem Biophys 216: 178-185
20. Monks TJ, Hanzlik RP, Cohen GM, Ross D and Graham DG (1992). Contemporary issues in toxicology. Quinone chemistry and toxicity. Toxicol Appl Pharmacol 112: 2-16
21. O'Brien PJ (1991) Molecular mechanisms of quinone cytotoxicity. Chem-Biol Interact 80: 1-41
22. Paris CN and Scidman MM (1992) A signature element distinguishes sibling and independent mutations in a shuttle vector plasmid. Gene 117:1-5
23. Prochaska HJ, Santamaria AB and Talalay P (1992) Rapid detection of inducers of enzymes that protect against carcinogens. Proc Natl Acad Sci USA 89: 2398-2398
24. Rushmore TH and Pickett CB (1993) Glutathione-S-transferases, structure, regulation and therapeutic implications. J Biol Chem 268: 11475-11478
25. Sakai A, Miyata N and Takahashi A (1995) Initiating activity of quinones in the two-stage transformation of BALB/3T3 cells. Carcinogenesis 16: 477-481
26. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press: Plainview, NY
27. Talalay P, Fahey JW, Holtzclaw, WD, Prestera T and Zhang Y (1995) Chemoprevention against cancer by phase 2 enzyme induction. Toxicol Lett 82-83: 173-179
28. Yamano S, Aoyama T, Mcbride OW, Hardwick JP, Gelboin HV and Gonzalez FJ (1989). Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localizalion of the CYPOR gene to chromosome 7. Mol Pharm 35: 83-88
29. Zhang Y, Talalay P, Cho C, Posner GH (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2403