Relationship between radical intensity and cytotoxic activity of dopamine-related compounds

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 1069-1074

  Kawase, Masami ^a   Motohashi, Noboru ^b   Kurihara, Teruo ^a   Inagaki, Masahiro ^c   Satoh, Kazue ^c   Sakagami, Hiroshi ^d  

^a JOSAI UNIVERSITY   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

spin density; Ascorbic acid; Cytotoxicity; Dopamine analogs; Radical intensity; Structure activity relationship

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; ASCORBIC ACID; DOPAMINE; DOPAMINE DERIVATIVE; NORADRENALIN; RADICAL;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HOMOGENATE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; METABOLITE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; DOPAMINE; FREE RADICALS; HL-60 CELLS; HUMANS; MALE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031813679     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Yamafuji K, Murakami H and Shinozuka M: Antitumor activity of dopa, dopamine, noradrenalin or adrenalin and their reaction with nucleic acids. Z Krebsfosch 73: 195-203, 1970.
2. Dasgupta PS and Lahiri T: Dopamine inhibits sarcoma-180 tumor growth in vivo. Indian J Cancer Chemother 7: 27-30, 1985.
3. Chelmicka-Szorc E and Arnason B: Effect of 6-hydroxydopamine on tumor growth. Cancer Res 36: 2382-2384, 1976.
4. Boulos BM, Dajuvone C and Azarnoff DL: A new method for increasing chemotherapeutic drug concentration in the tumor tissue. Panminerva Med 18: 95-98, 1976.
5. (a) Prasad KN, Gilmer KN, Sahu SK and Becker G: Effect of neurotransmitters, guanosine triphosphate, and divalent ions on the regulation of adenylate cyclase activity in malignant and adenosine cyclic 3′:5′-monophosphate-induced "differentiated" neuroblastoma cells. Cancer Res 35: 77-81, 1975.
6. (b) Kumar S, Becker G and Prasad KN: Cyclic adenosine 3′:5′-monophosphate phosphodiesterase activity in malignant and cyclic adenosine 3′:5′-monophosphate-induced "differentiated" neuroblastoma cells. Cancer Res 35: 82-87, 1975.
7. Wick MM: Levodopa and dopamine analogs: Dihydroxy and trihydroxybenzylamines as novel quinol antitumor agents in experimental leukemia in vivo. Cancer Treat Rep 65: 861-867, 1981.
8. Driscoll JS, Melnick NR, Quinn FR, Lomax N, Davignon JP, Ing R, Abbott BJ, Congleton G and Dudeck L: Psychotropic drugs as potential antitumor agents: A selective screening study. Cancer Treat Rep 62: 45-74, 1978.
9. Driscoll J: Catecholamine analogs as potential antitumor agents. J Pharm Sci 68: 1519-1521, 1979.
10. Reynolds CP and Perez-Polo JR: Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines. Neurosci Lett 26: 151-155, 1981.
11. Tiffany-Castiglioni E, Saneto RP, Proctor PH and Perez-Polo JR: Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line. Biochem Pharmacol 31: 181-188, 1982.
12. Uretsky NJ and Iversen LL: Effects of 6-hydroxydopamine on noradrenaline-containing neurons in the rat brain. Nature 221: 557-559, 1969.
13. Purpura P, Westman L, Will P, Eidelman A, Kagan VE, Osipov AN and Schor NF: Adjunctive treatment of murine neuroblastoma with 6-hydroxydopamine and tempol. Cancer Res 56; 2336-2342, 1996.
14. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
15. Sakagami H, Satoh K, Hatano T, Yoshida T and Okuda T: Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis. Anticancer Res 17: 377-380, 1997.
16. Satoh K, Sakagami H and Motohashi N: Radical modulation activity of benzo[α]phenothiazine. Anticancer Res 17: 2539-2544, 1997.
17. Satoh K, Sakagami H, Kurihara T and Motohashi N: Radical intensity and differentiation-inducing activity of benzo[α]phenothiazines and phenothiazines. Anticancer Res 17: 2465-2470, 1997.
18. Kawase M, Motohashi N, Niwa M and Nozaki M: Use of the triflamide group for Friedel-Crafts acylation of N-(ß-phenethyl) amino acids to 3-benzazepine derivatives. Heterocycles 45: 1121-1129, 1997.
19. Sakagami H, Satoh K, Fukuchi K, Gomi K and Takeda M: Effect of an iron-chelator on ascorbate-induced cytotoxicity. Free Radic Biol Med 23: 260-270, 1997.
20. Iriyama K, Yoshiura M, Iwamoto T and Ozaki Y: Simultaneous determination of uric and ascorbic acids in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection. Anal Biochem 141: 238-243, 1984.
21. Stewart JJP: MOPAC 93. JCPE#P081.
22. Sakagami H, Asano K, Fukuchi K, Gomi K, Ota H, Kazama K, Tanuma S and Kochi K: Induction of tumor degeneration by sodium benzylideneascorbate. Anticancer Res 11: 1533-1538, 1991.