Electroporation therapy of human larynx tumors HEp-2 implanted in nude mice

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 999-1004

  Nanda, G S ^a   Sun, F X ^b   Hofmann, G A ^a   Hoffman, R M ^b   Dev, S B ^a  

^a Inovio Biomedical Corporation   (United States)

^b ANTICANCER INC   (United States)

Author keywords

Bleomycin; Electrochemotherapy; Electroporation therapy; Head and neck cancer; Larynx cancer

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER REGRESSION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG PENETRATION; ELECTROCHEMOTHERAPY; ELECTROPORATION; HISTOPATHOLOGY; INTRATUMORAL DRUG ADMINISTRATION; LARYNX CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME; XENOGRAFT;

EID: 0031813674     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Parkin DM, Pisani P, Ferlay J: Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606, 1993.
2. Parker SL, Tong T, Bolden S, Wingo PA: Cancer Statistics, 1996. CA Cancer J Clin 46: 5-27, 1996.
3. Batsakis, JG: Tumors of head and neck: clinical and pathological considerations, Williams and Wilkins, Baltimore, 574, 1979.
4. Gupta PK: Drug targeting in Cancer Chemotherapy: A Clinical Perspective. J Phamm Sci 79(11): 949-962, 1990.
5. Okino M, Mohn H: Effects of a high-voltage electrical impulse and an anticancer drug on in vivo growing tumors. Jpn J Cancer Res 78: 1319-1321, 1987.
6. Dev SB, Hofmann GA: Electrochemotherapy - a novel method of cancer treatment. Cancer Treat Rev 20: 105-115, 1994.
7. Hofmann GA, Dev SB, and Nanda GS: Electrochemotherapy: Transition from laboratory to the clinic. IEEE Eng Med Biol 15(6): 124-132, 1996.
8. Dev SB, Nanda GS, An Z, Wang X, Huffman RM and Hofmann GA: Effective electroporation therapy of human pancreatic tumors implanted in nude mice. Drug Delivery 4(4): 293-299, 1997.
9. Mir LM, Belehradek M, Domenge C, Orlowski S, Poddevin B, Belehradek JJ, Schwaab G, Luboinski B and Paoletti C: Electrochemotherapy, a novel antitumor treatment: first clinical trial. CR Acad Sci Paris III 313(3): 613-618, 1991.
10. Belehradek JJ, Orlowski S, Poddevin B, Paoletti C and Mir LM: Electrochemotherapy of spontaneous mammary tumors in mice. Eur J Cancer 27: 73-76, 1991.
11. Heller R, Jaroszeski MJ, Glass LF, Messina JL and Rapaport DP: Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer 77: 964-966, 1996.
12. Rudolf Z, Stabuc B, Cemazar M, Miklavcic D, Vodovnik L and Sersa G: Electrochemotherapy with bleomycin The first clinical experience in malignant melanoma patients. Radiol Oncol 29: 229-235, 1995.
13. Jaroszeski MJ, Gilbert RA and Heller R: In vivo antitumor effects of electrochemotherapy in a hepatoma model. Biochim Biophys Acta 1134: 15-18, 1997.
14. Kanesada H: Anticancer effect of high voltage pulses combined with concentration dependent anticancer drugs on Lewis lung carcinoma, in vivo. J Jpn Soc Cancer Ther 25(11): 2640-2648, 1990.
15. Salford LG, Persson BRR, Brun A, Ceberg CP, Kongstad P and Mir LMA: New brain tumor therapy combining bleomycin with in vivo electropermeabilization. Biochem Biophys Res Comm 194(2): 938-943, 1993.
16. Yabushita H, Yoshikawa K, Hirata M, Furuya H, Hojyoh T, Fukatsu H, Noguch M and Nakanishi M: Effects of electrochemotherapy on CaSki cells derived from a cervical squamous cell carcinoma. Gynecologic Oncology 65: 267-303, 1997.
17. Kinosita K, Tsong TY: Voltage induced formation and hemolysis of human erythrocytes. Biochim Biophys Acta 471: 227-242, 1979.
18. Tounekti O, Pron G, Belehradek J and Mir LM: Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized. Cancer Res 53: 5462-5469, 1993.