Prognostic significance of different biological markers (DNA index, PCNA index, apoptosis, p53, karyotype) in 126 adenocarcinoma gastric biopsies

Anticancer Research

Volumn 18, Issue 4 B, 1998, Pages 2819-2825

  Matturri, L ^a   Biondo, B ^a   Cazzullo, A ^a   Colombo, B ^a   Giordano, F ^b   Guarino, M ^b   Pallotti, F ^b   Turconi, P ^a   Lavezzi, A M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b DESIO HOSPITAL   (Italy)

Author keywords

Apoptosis; DNA content; Gastric cancer; p53; PCNA labeling index; Trisomy 7

Indexed keywords

BIOLOGICAL MARKER; CYCLINE; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER STAGING; CHROMOSOME 7; CYTOMETRY; DIPLOIDY; DNA CONTENT; DNA DETERMINATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GASTRECTOMY; GENE MUTATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KARYOTYPE; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SIGNET RING CARCINOMA; STOMACH ADENOCARCINOMA; STOMACH BIOPSY; TRISOMY; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; APOPTOSIS; CHROMOSOMES, HUMAN, PAIR 7; DIPLOIDY; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MALE; MIDDLE AGED; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031813505     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Blot WJ, Devesa SS, Kneller RW, Fraumeni JF: Rising incidence of adenocarcinoma of the esophagus and gastric cancer. JAMA 265: 1287-1289, 1991.
2. Marubini E, Bonfanti G, Bozetti F, Boracchi P, Amadori D, Folli S et al: A prognostic score for patients resected for gastric cancer. Eur J Cancer 29A(6): 845-850, 1993.
3. ReMine WH: Partial gastrectomy and subtotal gastric resection with introductory comments on factors that may affect prognosis. In: ReMine WH, Priestley JT, Berkson J, editors. Cancer of the Stomach. Philadelphia: WB Saunders, 1964: 86-106.
4. MacDonald JS, Gunderson LL, Cohn I: Cancer of the stomach. In: De Vita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. 2nd ed. Philadelphia: JB Lippincott, 1982: 534-562.
5. Yonemura Y, Sugijama K, Fujimura T, De Aretxabala X Kamata T, Kosaka T: Correlation of DNA ploidy and proliferative activity in human gastric cancer. Cancer 62: 1497-1502, 1988.
6. Ohyama S, Yonemura Y, Miyazaki I: Prognostic value of S-phase fraction and DNA ploidy studied with in vivo administration of bromodeoxyuridine on human gastric cancers. Cancer 65: 116-121, 1990.
7. Yonemura Y, Ooyama S, Sugiyama K, Kamata T, De Aretxabala X, Kimura H: Retrospective analysis of the prognostic significance of DNA ploidy patterns and S- phase fraction in gastric carcinoma. Cancer Res 50: 509-514, 1990.
8. Flyger HL, Christensen IJ, Thorup J, Hakansson TU, Norgaard T: DNA aneuploidy in gastric carcinoma. Flow cytometric data related to survival, location and histopathologic findings. Scand J Gastroenterol 30: 258-264, 1995.
9. Stratmann H, Decker D, Hirner A, Bollmann R: Clinical importance and prognostic value of the image-DNA-cytometry for patients with gastric cancer. Gen Diagn Pathol 142: 97-100, 1996.
10. Watanabe H, Jass JR, Sobin LH: Histological typing of esophageal and gastric tumours. 2nd ed. Berlin: Springer-Verlag, 1990: 20-6.
11. Yu C, Woods A, Levison D: The application of immunohistochemistry in assessment of cellular proliferation. In: Assessment of Cell Proliferation in Clinical Practice. P.Hall, D.Levison, N.Wright, editors. Berlin: Springer-Verlag, 1991: 134-6.
12. Garcia RL, Coltrera MD, Gown AM: Analysis of proliferative grade using anti PCNA/Cyclin in fixed embedded tissues. Am J Pathol 134: 733-739, 1989.
13. Maeda K, Chung S, Takatsuka S, Ogawa Y, Onoda N, et al: Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma. Br J Cancer 72: 319-323, 1995.
14. Bown NP: Chromosome studies of solid tumours. J Clin Pathol 556-60, 1992.
15. Sandberg M, Turc-Carel C: The cytogenetics of solid tumours. Relation to diagnosis, classification and pathology. Cancer 59: 387-395, 1987.
16. Ferti-Passantonoioulon AD, Panani AD, Vlachos JD, Raptis SA: Common cytogenetic findings in gastric cancer. Cancer Genet Cytogenet 24: 63-74, 1987.
17. Panani AD, Ferti A, Malliaros S, Raptis S: Cytogenetic study of 11 gastric adenocarcinomas. Cancer Genet Cytogenet 81: 169-172, 1995.
18. Xiao S, Geng JS, Feng XL, Liu XQ, Liu QZ, Li P: Cytogenetic studies of eight primary gastric cancers. Cancer Genet Cytogenet 58: 79-84, 1992.
19. Rao PH, Mathew S, Kelsen DP, Chaganti RS: Cytogenetics of gastric and esophageal adenocarcinomas. Cancer Genet Cytogenet 81: 139-143, 1995.
20. Cremer T, Landegent J, Bruckner A et al: Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques. Hum Genet 74: 346-352, 1986.
21. Poddighe PJ, Ramaekers FCS, Hopman AHN: Interphase cytogenetics of tumours. J Pathol 166: 215-224, 1992.
22. Nederlof PM, van der Filer S, Raap AK, Tanke HJ et al: Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization. Cancer Genet Cytogenet 42: 87-98, 1989.
23. Han K, Oh EJ, Kim YS, Kim YG, Lee KY et al: Chromosomal numerical aberrations in gastric carcinoma: analysis of eighteen cases using in situ hybridization. Cancer Genet Cytogenet 92: 122-129, 1996.
24. Rao PH, Mathew S, Lauwers G, Rodriguez E, kelsen DP, Chaganti RS: Interphase cytogenetics of gastric and esophageal adenocarcinomas. Diagn Mol Pathol 2: 264-268, 1993.
25. Dekken H, Pizolo JG, Kelsen DP, Melamed MR: Targeted cytogenetic analysis of gastric tumors by in situ hybridization with a set of chromosome-specific DNA probes. Cancer 66: 491-497, 1990.
26. Proceedings 20th International Workshops on Human Gene Mapping. Los Angeles, Cytogenet Cell Genet 37: 1-666, 1984. 13
27. D'Agnano J, Savarese A, D'Angelo C, Carlini M, Garofalo A et al: DNA ploidy, proliferate index and epidermal growth factor receptor expression in patients with gastric cancers. Lab Invest 72: 432-438, 1995.
28. Ioachim E, Goussia A, Stefanou D, Agnanus NJ: Expression of p53 protein in gastric cancer: an immunohistochemical study with correlation to proliferative activity. Anticancer Res 17: 513-517, 1997.
29. Koshida Y, Saegusa M, Okayasu I: Apoptosis, cell proliferation and expression of Bc1-2 and Bax in gastric carcinomas: immunohistochemical and clinicopathological study. Br J Cancer 75: 367-373, 1997.
30. Shinohara T, Ohshima K, Murayama H, Kikuchi M, Yamashita Y: Apoptosis and proliferation in gastric carcinoma: the association with histological type. Histopathol 29: 123-129, 1996.
31. Kasagi N, Gomyo Y, Shirai H, Tsujitani S, Ito H: Apoptotic cell death in human gastric carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Jpn J Cancer Res 85: 939-945, 1994.