Acute insulin response to intravenous glucagon in polycystic ovary syndrome

Human Reproduction

Volumn 13, Issue 4, 1998, Pages 847-851

  Ciampelli, Mario ^a   Fulghesu, Anna M ^a   Murgia, Francesca ^a   Guido, Maurizio ^a   Cucinelli, Francesco ^a   Apa, Rosanna ^a   Caruso, Alessandro ^a   Lanzone, Antonio ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

Glucagon; Insulin; Obesity; Polycystic ovary syndrome

Indexed keywords

GLUCAGON; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; FEMALE; HUMAN; INSULIN RELEASE; INSULIN RESPONSE; INTERMETHOD COMPARISON; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE;

FALLOPIA;

EID: 0031811731     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.4.847     Document Type: Article

References (23)

1. Barbieri, R.I. and Ryan, K.J. (1983) Hyperandrogenism, insulin resistance and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiology features. Am. J. Obstet. Gynecol., 147, 90-101.
2. Bardet, S., Rohmer, V., Maugendre, D. et al. (1991) Acute insulin response to intravenous glucose, glucagon and arginine in some subjects at risk for type I (insulin dependent) diabetes mellitus. Diabetologia, 34, 648-654.
3. Buffington, C.K. and Kitabchi, A.E. (1994) Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. Metabolism, 11, 1367-1372.
4. Burghen, G.A., Givensm J.R. and Kitabchi, A.E. (1980) Correlation of hyperandrogenism and hyperinsulinism in polycystic ovarian disease. J. Clin. Endocrinol. Metab., 50, 113-116.
5. Ciampelli, M., Fulghesu, A.M., Cucinelli, F. et al. (1997) Heterogeneity in β-cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod., 12, 1897-1901.
6. Dunaif, A., Graf, M., Mandeli, M. et al. (1987) Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. J. Clin. Endocrinol. Metab., 65, 499-507.
7. Dunaif. A., Mandeli, J., Fluhr, H. et al. (1988) The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal secretion in patients with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 66, 131-139.
8. Fulghesu, A.M., Ciampelli, M., Fortini, A. et al. (1995) Effect of opioid blockade on insulin metabolism in polycystic ovarian disease. Hum. Reprod., 10, 2253-2257.
9. Golland, I.M., Vaughan Williams, C.A., Shalet, S.M. et al. (1990) Glucagon in women with polycystic ovary syndrome (PCO): relationship to abnormalities of insulin and androgens. Clin. Endocrinol., 33, 645-651.
10. Holte, J., Bergh, T., Berne, C. et al. (1994) Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J. Clin. Endocrinol. Metab., 78, 1052-1058.
11. Holte, J., Bergh, T., Berne, C. et al. (1995) Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 80, 2586-2593.
12. Lanzone, A., Fulghesu, A.M., Andreani, C.L. et al. (1990) Insulin secretion in polycystic ovarian disease: effect of ovarian suppression by GnRH agonist. Hum. Reprod., 5, 143-149.
13. Lanzone, A., Fulghesu, A.M., Cucinelli, F. et al. (1995) Evidence of a distinct derangement of opioid tone in hyperinsulinemic patients with polycystic ovarian syndrome: relationship with insulin and luteinizing hormone secretion. J. Clin. Endocrinol. Metab., 80, 3501-3506.
14. Lanzone, A., Fulghesu, A.M., Cucinelli, F. et al. (1996) Preconceptional and gestational evaluation of insulin secretion in patients with polycystic ovary syndrome. Hum. Reprod., 11, 2382-2386.
15. Lorentz, F.H. (1929) Ein never costitutios index. Klin. Wochenschr., 8, 348-354.
16. National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes, 28, 1039-1057.
17. Ovesen, P., Moller, J., Ingerslev, H.J. et al. (1993) Normal basal and stimulated fuel metabolism in lean women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 77, 1636-1640.
18. Samols, E., Marri, G. and Marks, V. (1966) Interrelationship of glucagon, insulin and glucose. Diabetes, 15, 855-866.
19. Snorgaard, O., Hasselstrom, K., Lumholtz, I.B. et al. (1988) Insulin/c- peptide response to intravenous glucagon. Acta Endocrinol. (Copenh.), 117, 109-115.
20. Stuart, C.A., Peters, E.J., Prince, M.J. et al. (1986) Insulin resistance with acanthosis nigricans: the roles of obesity and androgen excess. Metabolism, 35, 197-205.
21. Vialettes, B., Zevaco-Mattei, C., Thirion, X. et al. (1993) Acute insulin response to glucose and glucagon in subjects at risk of developing Type I diabetes. Diab. Care, 16, 973-977.
22. Weber, R.F.A., Pache, T.D., Jacobs, M.L. et al. (1993) The relationship between clinical manifestations of polycystic ovary syndrome and β-cells function. Clin. Endocrinol., 38, 295-300.
23. Widèn, E.I.M., Eriksson, J.G., Ekstrand, A.V. et al. (1992) The relationship between first-phase insulin secretion and glucose metabolism. Acta Endocrinol. (Copenh.), 127, 289-293.