A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARα, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia

British Journal of Haematology

Volumn 101, Issue 2, 1998, Pages 338-340

  Langabeer, S E ^a   Grimwade, D ^a,b   Walker, H ^a   Rogers, J R ^a   Burnett, A K ^c   Goldstone, A H ^a   Linch, D C ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

AML; Cryptic rearrangements; Cytogenetics; Secondary abnormalities

Indexed keywords

TUMOR MARKER;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER SCREENING; CANCER SURVIVAL; CHROMOSOME 9Q; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; HUMAN; KARYOTYPE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TRISOMY 8;

ACUTE DISEASE; ADULT; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 8; GENE REARRANGEMENT; HUMANS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOID; ONCOGENE PROTEINS, FUSION; TRANSLOCATION, GENETIC; TRISOMY; TUMOR MARKERS, BIOLOGICAL;

EID: 0031811713     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00686.x     Document Type: Article

References (12)

1. Andrieu, V., Radford-Weiss, I., Troussard, X., Chane, C., Valensi, F., Guesnu, M., Haddad, E., Viguier, F., Dreyfus, F., Varet, B., Flandrin, G. & Macintyre, E. (1996) Molecular detection of the t(8:21)/AMM1-ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype. British Journal of Haematology, 92, 855-865.
2. Caligiuri, M.A., Schichman, S.A., Strout, M.P., Mrozek, K., Baer, M.R., Frankel, S.R., Barcos, M., Herzig, G.P., Croce, C.M. & Bloomfield, C.D. (1994) Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations. Cancer Research, 54, 370-373.
3. Grimwade, U., Howe, K., Langabeer, S., Davies, L., Oliver, F., Walker, H., Swirsky, D., Wheatley, K., Goldstone, A., Burnett, A. & Solomon, E. (1996a) Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment in patients entered into the MRC ATRA trial. British Journal of Haematology, 94, 557-575.
4. Grimwade, D., Langabeer, S., Gorman, P., Howe, K., Duprez, E., Walker, H., Wheatley, K., Goldstone, A., Burnett, A. & Solomon, E., (1997) Molecular characterisation of patients with APL entered into the UK MRC ATRA trial: relationship of PML breakpoint with additional cytogenetic abnormalities and outcome. Blood, 90, (Suppl. 1), 271a.
5. Grimwade, D., Walker, H., Harrison, C., Oliver, E., Wheatley, K., Harrison, G., Gray, R., Hann, I., Stevens, R., Goldstone, A. & Burnett, A. (1996b) Impact of diagnostic cytogenelics on outcome in AML: analysis of 1613 patients-entered into the UK MRC AML 10 trial. Blood, 88, (Suppl. 1), 2525a.
6. Hiorns, L.R., Min, T., Swansbury, G.J., Zelent, A., Dyer, M.J.S. & Catovsky, D. (1994) Interstitial insertion of the retinoic acid receptor gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. Blood, 83, 2946-2951.
7. Johansson, B., Mertens, F. & Mitelman, F. (1994) Secondary chromosomal abnormalities in acute leukemias. Leukemia, 8, 953-962.
8. Langabeer, S.E., Walker, H., Gale, R.E., Wheatley, K., Burnett, A.K., Goldstone, A.H. & Linch, D.C. (1997a) Frequency of CBFB/MYH11 fusion transcripts in patients entered into the UK MRC AML trials. British Journal of Haematology, 96, 736-739.
9. Langabeer, S.E., Walker, H., Rogers, J.R., Burnett, A.K., Wheatley, K., Swirsky, D., Goldstone, A.H. & Linch, D.C. (1997b) Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. British Journal of Haematology, 99, 925-928.
10. Miller, W.H., Kakizuka, A., Frankel, S.R., Warrell, R.P., De Blasio, A., Levine, K., Evans, R. & Dmitrovsky, K. (1992) Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor a clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 89, 2694-2698.
11. Nucifora, G., Dickenstein, J.I., Torbenson, V., Roulston, D., Rowley, J. & Vardiman, J.W. (1994) Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21). Leukemia, 8, 1533-1538.
12. Poirel, H., Radford-Weiss, I., Rack, K., Troussard, X., Veil, A., Valensi, F., Picard, F., Guesna, M., Leboeuf, D., Meile, J., Dreyfus, F., Flandrin, G. & Macintyre, H. (1995) Detection of the chromosome 16 CBFB/MYH11 fusion transcripts in myelomonocytic leukemias. Blood, 85, 1313-1322.