Differential activation of the c-Ki-ras-2 proto-oncogene in human colorectal carcinoma

Anticancer Research

Volumn 18, Issue 4 A, 1998, Pages 2323-2325

  Halatsch, Marc E ^a,c   Hirsch Ernst, Karen I ^a   Weinel, Rolf J ^b   Kahl, Georg F ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Bad Soden Salmünster Hospital   (Germany)

^c CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

c Ki ras 2 proto oncogene; Colorectal carcinoma; Oligonucleotide hybridization; Point mutation; Polymerase chain reaction

Indexed keywords

DNA; OLIGONUCLEOTIDE;

ARTICLE; CODON; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA HYBRIDIZATION; GENE ACTIVATION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

CODON; COLORECTAL NEOPLASMS; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; PANCREATIC NEOPLASMS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS P21(RAS); TUMOR CELLS, CULTURED;

EID: 0031811525     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Barbacid M: ras genes. Annu Rev Biochem 56: 779-827, 1987.
2. Bartram CR, Ludwig WD, Hiddemann W et al: Acute myeloid leukemia: analysis of ras gene mutations and clonality defined by polymorphic X-linked loci. Leukemia 3: 247-256, 1989.
3. van't Veer LJ, Burgering BMT, Versteeg R et al: N-ras mutations in human cutaneous melanoma correlated with sun exposure. Mol Cell Biol 9: 3114-3116, 1989.
4. Almoguera C, Shibata D, Forrester F et al: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53: 549-554, 1988.
5. Höhne MW, Halatsch M-E, Kahl GF et al: Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic carcinoma. Cancer Res 52: 2616-2619, 1992.
6. Smit VTHBM, Boot AJM, Smits AMM et al: KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucl Acids Res 16: 7773-7782, 1988.
7. Bos JL, Fearon ER, Hamilton SR et al: Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293-297, 1987.
8. Forrester K, Almoguera C, Han K et al: Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298-303, 1987.
9. Enomoto T, Fujita M, Inoue M et al: Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. Am J Clin Pathol 103: 224-230, 1995.
10. Rosell R, Li S, Skacel Z et al: Prognostic impact of mutated K-ras gene iti surgically resected non-small cell lung cancer patients. Oncogene 8: 2407-2412, 1993.
11. Rochlitz CF, Heide I, de Kant E et al: Position specificity of Ki-ras oncogene mutations during the progression of colorectal carcinoma. Oncology 50: 70-76, 1993.
12. Chirgwin JM, Przybyla AE, MacDonald RJ et al: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294-5299, 1979.
13. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503-517, 1975.
14. Wood WI, Gitschier J, Lasky LA et al: Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc Natl Acad Sci USA 82: 1585-1588, 1985.
15. Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
16. Zhu D, Keohavong P, Finkelstein SD et al: K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients. Cancer Res 57: 2485-2492, 1997.
17. Yuasa Y, Reddy EP, Rhim JS et al: Activated N-ras in a human rectal carcinoma cell line associated with clonal homozygosity in myb locus restriction fragment polymorphism. Jap J Cancer Res 77: 639-647, 1986.
18. Kobayashi H, Kim N, Halatsch M-E et al: Specificity of ribozyme designed for mutated DHFR mRNA. Biochem Pharmacol 47: 1607-1613, 1994.