Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: A novel derivative

Therapeutic Drug Monitoring

Volumn 20, Issue 3, 1998, Pages 313-318

  Dasgupta, Amitava ^a,c   Appenzeller, Peter ^b   Moore, Jeffrey ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

2,2,2 trichloroethyl carbamate; Gas chromatography mass spectrometry; Mexiletine

Indexed keywords

AMPHETAMINE DERIVATIVE; CHLOROFORMIC ACID ETHYL ESTER; DICHLOROMETHANE; MEXILETINE;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MONITORING; GAS CHROMATOGRAPHY; HEART VENTRICLE ARRHYTHMIA; MASS SPECTROMETER; PRIORITY JOURNAL;

EID: 0031811036     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199806000-00012     Document Type: Article

References (14)

1. Talbot RG, Julian DG, Prescou LF. Long term treatment of ventricular arrhythmias with oral mexiletine. Am Henrt J 1976;91:58-66.
2. Campbell NPS, Kelly JG, Adgey AAJ, Shanks RG. The clinical pharmacology of mexiletine. Br J Clin Pharm 1978;6:103-8.
3. Jequir P, Jones R, MacKintosh A. Fatal mexiletine overdose. Lancet 1976;1:492.
4. Kempton J, Levine B, Manoukian A, Smialek JE. A mexiletine intoxication. Presented at the Annual Meeting of the Society of the Forensic Toxicologists; October 15, 1993; Phoenix, Arizona.
5. Gupta R, Lew M. Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent. J Chromatogr 1985;344:221-30.
6. Paczkowski D, Filipek M, Mielniczuk Z, Andrzejczak J. Poplawska W, Sitkiewicz D. Simultaneous determination of mexiletine and four hydroxylated metabolites in human serum by high performance liquid chromatography and its application to pharmacokinetic studies. J Chromatogr 1992;573:235-46.
7. Minnigh MB, Alvin JD, Zemaitis MA. Determination of plasma mexiletine levels with gas chromatography-mass spectrometry and selected ion monitoring. J Chromatogr 1994;662:118-22.
8. Ji SG, Kong QH, Li X, Li P. Gas chromatographic determination of mexiletine in human plasma with flame ionization detection after reaction with carbon disulfide. Biomed Chrom 1993;7:196-9.
9. Bradbrook ID, James C, Rogers HJ. A rapid method for the determination of plasma mexiletine levels by gas chromatography. Br J Clin Pharm 1997;4:380-2.
10. Holt DW, Flanagan RJ, Hayler AM, Loizou M. Simple gas-liquid chromatographic method for the measurement of mexiletine and lignocaine in blood-plasma or serum. J Chromatogr 1979;169: 295-301.
11. Frydman A, Lafarge JP, Vial F, Rulliere R. New electron capture gas-liquid chromatographic method for the determination of mexiletine plasma level in man. J Chromatogr 1978;145:401-11.
12. Vasiliades J, Kellett J, Cox RS. Gas chromatographic determination of mexiletine with nitrogen selective detector. Am J Clin Pathol 1984;81:776-9.
13. Kempton J, Manoukian A, Levine B, Smialek J. A mexiletine intoxication. J Anal Toxicol 1994;18:346-7.
14. Rohrig T, Harty L. Postmortem distribution of mexiletine in a fatal overdose. J Anal Toxicol 1994;18:354-6.