The neurology of male sexual dysfunction and its investigation by clinical neurophysiological methods

British Journal of Urology

Volumn 81, Issue 6, 1998, Pages 785-795

  Fowler, C J ^a,b  

^a National Hospital of Neurology and Neiiwsurgery   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAUDA EQUINA SYNDROME; CORPUS CAVERNOSUM; DEGENERATIVE DISEASE; ELECTROMYOGRAPHY; EPILEPSY; EVOKED MUSCLE RESPONSE; EVOKED SOMATOSENSORY RESPONSE; HUMAN; MALE; MALE SEXUAL DYSFUNCTION; MULTIPLE SCLEROSIS; NEUROLOGY; NEUROPHYSIOLOGY; PARASYMPATHETIC INNERVATION; PENIS ERECTION; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PUDENDAL NERVE; REVIEW; SPINAL CORD INJURY; SPINAL REFLEX; SYMPATHETIC INNERVATION;

BRAIN DISEASES; ELECTROMYOGRAPHY; GENITALIA, MALE; HUMANS; MALE; NERVOUS SYSTEM DISEASES; PENILE ERECTION; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SPINAL CORD DISEASES;

EID: 0031810020     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.1998.00640.x     Document Type: Review

References (97)

1. Brindley GS. Pathophysiology of erection and ejaculation. In Whitfield HN, Hendry WF, eds. Textbook of Genitourinary Surgery. Edinburgh: Churchill Livingstone, 1985: 1083-94
2. Brindley GS. Neurophysiology. In Kirby R. Carson C. Webster G, eds. Impotence: Diagnosis and Management of Male Erectile Dysfunction. Oxford: Butterworth-Heinemann, 1991: 27-31
3. de Groat W. Neural control of the urinary bladder and sexual organs. In Bannister R, Mathias C, eds. Autonomie Failure. 3rd Edn. Oxford: Oxford University Press. 1992: 129-59
4. de Groat W. Steers W. The neuroanatomy and neurophysiology of penile erection. In Tanagho E, Lue T. McClure D. eds. Impotence and infertility. Baltimore: Williams & Wilkins. 1988: 3-27
5. Lue T. Tanagho E. Physiology of erection and pharmacological management of impotence. / Urol 1987: 137: 829-36
6. Carrier S. Brock C. Kour N. Lue T. Pathophysiology of erectile dysfunction. Urology 1993: 42: 468-81
7. Gil-Vernet J. Alvarez-Vijande R. Gil-Vernet A. Gii-Vernet J. Ejaculation in men: a dynamic endorectal ultrasono-graphical study. Br }Urol 1994: 73: 442-8
8. Tiihonen J, Kikka J. Kuplia ], Partanen K. Vainio P. Airaksinen f. Increase in cerebral blood flow of right prefrontal cortex in man during orgasm. Neurosci Letts 1994: 170: 241-3
9. Lundberg P. Brattberg A. Impotence -the neurological risk factor. Int ] Impôt Res 1993; 5: 241-3
10. Miller B. Cummings J. Mclntyre H. Hypersexuality or altered sexual preference following brain injury. / Neural Neurosurg Psychial 1986: 49: 867-73
11. Hulling A-L. Muhr C. Lundberg P. Werner S. Prolactinomas in men: clinical characteristics and the effect of bromocriptine treatment. Acta Med Scand 1985: 217: 101-9
12. Lundberg P. Hulter B. Sexual dysfunction in patients with hypothalamo-pituitary disorders. Exp Clin Endocrin 1991: 98: 81-8
13. Shukla G, Srivastava 0. Katiyar B. Sexual disturbance in temporal lobe epilepsy: a controlled study. Br / Psychiat 1979; 134: 288-92
14. Blumer D, Walker A. Sexual behavior in temporal lobe epilepsy. Arch Neural 1967: 16: 37-43
15. Murialdo G. Galimberti C. Fonzi S et al. Sex hormones and pituitary function in male epileptic patients with altered or normal sexuality. Epilepsia 1995; 36: 360-5
16. Hierons R, Saunders M. Impotence in patients with temporal lobe lesions. Lancet 1966; 2: 761
17. Guldner G, Morrell M. Nocturnal penile tumesence and rigidity evaluation in men with epilepsy. Epilepsia 1996; 37: 1211-4
18. Christianson S. Silfvenius H. Saisa ]. Nilsson M. Life satisfaction and sexuality in patients operated for epilepsy. Acta Neural Scand 1995: 92: 1-6
19. Elliott M. Biever L. Head injury and sexual dysfunction. Brain Inj 1996: 10: 703-17
20. O'Carroll R. Woodrow J. Maroun F. Psychosexual and psychosocial sequelae of closed head injury. Brain Inj 1991: 5: 303-13
21. Clark J. Raggatt P, Edwards 0. Hypothalamic hypogonadism following major head injury. Clin Endoc 1988; 29: 153-65
22. Lezak M. Living with the characterologically altered brain injured patient. / Clin Psych 1978; 39: 592-8
23. Argiolas A. Melis M. Mauri A. Gessa G. Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not ACTH in rats. Brain Res 1987; 421: 349-52
24. Heaton J, Morales A, Adams M, Johnston B, El-Rashidy R. Recovery of erectile function by the oral administration of apomorphine. Urology 1995: 45: 200-6
25. Beck RO, Betts CD. Fowler CJ. Genito-urinary dysfunction in Multiple System Atrophy: clinical features and treatment in 62 cases. / Urol 1994: 151: 1336-41
26. Singer C, Weiner WJ, Sanchez-Ramos JR. Ackerman M. Sexual dysfunction in men with Parkinson's Disease. / Neural Rehab 1989: 3: 199-204
27. Chandiramani VA, Palace J, Fowler CJ. How to recognise patients with parkinsonism who should not have urological surgery. Br ] Urol 1997: 80: 100-4
28. Brown RG. Jahanshahi M. Quinn N, Marsden CD. Sexual function in patients with Parkinson's disease and their partners. / Neural Neurosurg Psychiat 1990; 53: 480-6
29. Bors EH, Comarr AE. Neurological disturbances of sexual function with special references to 529 patients with spinal cord injury. Urol Survey 1960; 10: 191-222
30. Comarr AE. Sexual function among patients with spinal cord injury. Urol Int 1970; 25: 134-68
31. Leyson J (ed.). Sexual Rehabilitation of the spinal-cord-injured patient. Clifton: Humana Press, 1991
32. Mossman S, Kapoor R, Fowler CJ. Letter - spontaneous ejaculation secondary to spinal cord disease. / Neural Neurosurg Psychiat 1994; 57: 505-6
33. White J. Sweet W. Hawkins R. Nilges R. Anterolateral cordotomy: results, complications and causes of failure. Brain 1950; 73: 346-66
34. Beric A. Light J. Anorgasmia in anterior spinal cord syndrome. / Neural Neurosurg Psychiat 1993; 56: 548-51
35. Lilius HG. Valtonen EJ, Wikstrom J. Sexual problems in patients suffering from multiple sclerosis. / Chron Dis 1976; 29: 643
36. Valleroy ML, Kraft GH. Sexual dysfunction in multiple sclerosis. Arch Phys Med Rehab 1984; 65: 125-8
37. Minderhoud JM. Leehuis JG. Kremer J, Laban E, Smits. Sexual disturbances arising from multiple sclerosis. Acta Neural Scand 1984; 70: 299-306
38. Miller H. Simpson CA, Yeates WK. Bladder dysfunction in multiple sclerosis. Br Med] 1965; 1: 1265-9
39. Betts CD, Jones SJ. Fowler CG, Fowler CJ. Erectile dysfunction in multiple sclerosis; associated neurological and neurophysiological deficits and treatment of the condition. Brain 1994; 117: 1303-10
40. Betts CD, D'Mellow MT, Fowler CJ. Urinary symptoms and the neurological features of bladder dysfunction in multiple sclerosis. / Neural Neurosurg Psychiat 1993; 56: 245-50
41. Kirkeby HJ, Poulsen EU, Petersen T, Dorup J. Erectile dysfunction in multiple sclerosis. Neurology 1988: 38: 1366-71
42. Ghezzi A, Malvestiti G, Baldini S. Zaffaroni M. Zibetti A. Erectile impotence in multiple sclerosis: a neurophysiological study. / Neural 1995; 242: 123-6
43. Donohue J, Rowland R. Complications of retroperitoneal lymph node dissection. / Urol 1981; 125: 338
44. Skinner D. Melamud A, Lieskovsky G. Complications of thoraco-abdominal retroperitoneal lymph node dissection. / Urol 1982; 127: 1107
45. Jewett M, Kong Y, Goldberg S. Retroperitoneal lymphadenectomy for testis tumour with nerve sparing for ejaculation. / Urol 1988; 139: 1220
46. Donohue J, Foster R, Rowland R. Nerve sparing retroperitoneal lymphadenectomy with preservation of ejaculation. / Urol 1990; 144; 287
47. Comarr A, Vigue M. Sexual counseling among male and female patients with spinal cord and/or cauda equina injury. Part I Am ] Phys Med 1978; 57: 107-22
48. Maatman TJ, Montague DK. Martin LM. Erectile dysfunction in men with diabetes mellitus. Urology 1987; 29: 589
49. Vardi Y. Sprecher E, Kanter Y. Livne P, Hemli J, Yarnitsky Y. Polyneuropathy in impotence. Int J Impot Res 1996; 8: 65-8
50. Klein R. Klein B, Lee K, Moss S, Cruickshanks K. Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care 1996; 19: 135-41
51. Minhas S. Eardley I. Diabetic impotence. In Carson C. Kirby RS, Goldstein I eds, Textbook of Erectile Dysfunction. Oxford: Isis Medical Media. 1998. in press
52. Villaplana G, Rosino E, Cubillana P. Egea L, Pertusa P. Albacete M. Corino-Andrade disease (familial amyloidotic polineuropathy type 1) in Spain. Neurourol Urodynam 1997; 16: 55-61
53. Walsh P, Mostwin J. Radical prostatectomy and cystoprostatectomy with preservation of potency: results utilizing a new nerve sparing technique. Er] Urol 1984; 56: 694-7
54. Jonler M, Messing E. Rhodes P, Bruskewitz R. Sequelae of radical prostatectomy. Br J Urol 1994; 74: 352-8
55. Koeman M. Van Driel M, Weijmar Schultz W, Mensink H. Orgasm after radical prostatectomy. Br }Urol 1996; 77: 861-4
56. Leveckis J. Boucher N. Parys B, Reed M, Shorthouse A. Anderson J. Bladder and erectile dysfunction before and after rectal surgery for cancer. Br ] Urol 1995; 76: 752-6
57. Hanbury D, Sethia K. Erectile function following transurethral prostatectomy. Br J Urol 1995; 75: 12-3
58. Bullock N. Impotence after sclerotherapy of haemorrhoids: case report. Br Med J 1997; 314: 419
59. Bennani S. Evaluation of sub-trigonal injections in the treatment of the hyperactive bladder. Ann d'Urol 1994; 28: 13-9
60. Vodusek DB, Janko M. The bulbocavernosus reflex. A single motor neuron study. Brain 1990; 113: 813-20
61. Ertekin C, Reel F. Bulbocavernosus reflex in normal men and in patients with neurogenic bladder and/or impotence. / Neural Sei 1976; 28: 1-15
62. Wabrek AJ. Bulbocavernosus reflex testing in 100 consecutive cases of erectile dysfunction. Urology 1985; 25: 495-8
63. Herman CW. Weinberg H], Brown J. Testing for neurogenic impotence: a challenge. Urology 1986; 27: 318-21
64. Ertekin CA. O.Gurses AN, Turgut H. The value of somatosensory evoked potentials and bulbocavernosus reflex in patients with impotence. Acta Neural Scand 1985: 71:48-53
65. Kaneko S, Bradley WE. Penile electrodiagnosis. Value of bulbocavernosus reflex latency versus nerve conduction velocity of the dorsal nerve of the penis in diagnosis of diabetic impotence. / Urol 1987: 137: 933-5
66. Tackmann W, Porst H, Van Ahlen H. Bulbocavernosus reflex latencies and somatosensory evoked potentials after pudendal nerve stimulation in the diagnosis of impotence. ] Neural 1988; 235: 219-55
67. Desai KM. Dembny K. Morgan H, Gingell JC. Prothero D. Neurophysiological investigation of diabetic impotence. Are sacral response studies of value? Br J Urol 1988: 61: 68-73
68. Parys BT. Evans CM. Parsons KF. Bulbocavernosus reflex latency in the investigation of diabetic impotence. Br }Urol 1988: 61: 59-62
69. Vodusek DB. Zidar J. Pudendal nerve involvement in patients with hereditary motor and sensory neuropathy. Acta Neural Scand 1987: 76: 457-60
70. Sarica Y, Karacan I. Bulbocavernosus reflex to somatic and visceral nerve stimulation in normal subjects and in diabetics with erectile impotence. / Urol 1987: 138: 55-8
71. Fowler CJ, Ali Z, Kirby RS. Pryor JP. The value of testing for unmyeiinated fibre, sensory neuropathy in diabetic impotence. Br ] Urol 1988: 61: 63-7
72. Nogueira MC. Herbaut AG, Wespes E. Neurophysiological investigations of two hundred men with erectile dysfunction. Interest of bulbocavernosus reflex and pudendal evoked responses. Eur Neural 1990; 18: 37-41
73. Vardi Y. Yarnitsky D. Simri W. Honigman S. Hemli J. Bulbocavernous reflex latency in evaluation of diabetic impotence. Int ] Impôt Res 1992: 4: 97.1-97.4
74. Ho K. Ong B. Chong P. Teo W. The bulbocavernosus reflex in the assessment of neurogenic impotence in diabetic and non-diabetic men. Ann Acad Med Siny 1996; 25: 558-61
75. Haldeman S. Bradley WE. Bhatia N. Evoked responses from the pudendal nerve. / Vrol 1982: 128: 974-80
76. Rodi Z. Vodusek D, Denislic M. Clinical uroneurophysiological investigation in multiple sclerosis. Eur Neural 1996; 3: 574-80
77. Pickard RS. Powell PH. Schofield IS. The clinical application of dorsal penile nerve cerebral-evoked response recording in the investigation of impotence. Br / Vrol 1994; 74: 231-5
78. Bemelmans B, Meuleman E, Anten B, Doesburg W. Van Kerrebroeck P, Debruyne F. Penile sensory disorders in erectile dysfunction: results of a comprehensive neurourophysiological diagnostic evaluation in 123 patients. / Urol 1991; 146: 777-82
79. Ghezzi A. Callea L. Zaffaroni M, Montanini R, Tessera G. Motor potentials of bulbocavernosus muscle after transcranial and lumbar magnetic stimulation: comparative study with bulbocavernous reflex and pudendal evoked potentials. / Neural Neurosurg Psychiat 1991; 54: 524-6
80. Palace J. Chandiramani VA, Fowler CJ. Value of sphincter EMG in the diagnosis of Multiple System Atrophy. Muscle Nerve 1997; 20: 1396-403
81. Low P. Evaluation and Management of Clinical Autonomie Disorders. Boston: Little, Brown. 1993
82. Ravits J. Autonomie nervous system testing. Muscle Nerve 1997; 20: 919-37
83. Ewing D. Campbell I, Bell A. Clarke B. Vascular reflexes in diabetic autonomie neuropathy. Lancet 1973; 2: 1354-6
84. Robinson L. Woodcock J. Stephenson T. Results of investigation of impotence in patients with overt or probable neuropathy. Br ] Urol 1987: 60: 583-7
85. Quadri R, Veglio M. Flecchia M. Autonomie neuropathy and sexual impotence in diabetic patients: cardiovascular reflexes. Andrology 1989: 21: 346-52
86. Nisen H. Larsen A. Lindstrom B, Ruutu M. Virtanen J. Alfthan 0. Cardiovascular reflexes in the neurological evaluation of impotence. Br / Urol 1993: 71: 199-203
87. Yarnitsky D. Sprecher E. Vardi Y. Penile thermal sensation. / Urol 1996: 156: 391-3
88. Ertekin C. Ertekin N. Mutlu S. Almis A. Akcam A. Skin potentials (SP) recorded from the extremities and genital regions in normal and impotent subjects. Acta Neurol Scand 1987: 76: 28-36
89. Ertekin C. Almis S. Ertekin N. Sympathetic skin potentials and bulbocavernosus reflex in patients with chronic alcoholism and impotence. Eur Neurol 1990: 30: 334-7
90. Kunesch E, Reiners K. Muller-Mattheis V, Strohmeyer T. Ackermann R. Freund H. Neurological risk prolile in organic erectile impotence. / Neural Neiirosurg Psychiat 1992: 55: 275-81
91. Gerstenberg TC. Nordling J. Raid T, Wagner G. Standardized evaluation of erectile dysfunction in 95 consecutive patients. / Urol 1989: 141: 857-62
92. Wagner G. Gerstenberg T. Levin RJ. Electrical activity of corpus cavernosum during flaccidity and erection of the human penis: a new diagnostic method? / Urol 1989: 142: 723-5
93. Stief CG. Djamilian M. Anton P. de Riese W. Allhoff EP. Jonas U. Single potential analysis of cavernous electrical activity in impotent patients: a possible diagnostic method for autonomie cavernous dysfunction and cavernous smooth muscle degeneration. / Urol 1991: 146: 771-6
94. Yarnitsky D. Sprecher E. Barilan Y, Vardi Y. Corpus cavernosum electromyogram: spontaneous and evoked electrical activities. / Urol 1995: 153: 653-4
95. Yarnitsky D. Dashkovsky A. Rogovsk 7.. Vardi Y. Smooth muscle electromyography from rat urethra. Muscle Nerve 1997: 20: 1497-501
96. Truss M. Djamilian M. Tan H et al. Single potential analysis of cavernous electrical activity. Four years' experience in more than 500 patients with erectile dysfunction. Eur Urol 1993: 24: 358-65
97. Merckx L. de Bruyne R. Keuppens F. Electromyography of cavernous smooth muscle during flaccidity: evaluation of technique and normal values. Br }Urol 1993: 72: 353-8