Effects of an anti-IL-10 monoclonal antibody on rIFNβ-1b-mediated immune modulation. Relevance to multiple sclerosis

Journal of Neuroimmunology

Volumn 81, Issue 1-2, 1998, Pages 109-115

  Porrini, A M ^a   De Luca, G ^a   Gambi, D ^a   Reder, A T ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Antibody; Cytokine; IFN ; IFN ; Interferons; Interleukin 10; Multiple sclerosis; Suppressor function

Indexed keywords

GAMMA INTERFERON; INTERFERON BETA SERINE; INTERLEUKIN 10; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFECT; HUMAN; IMMUNOREGULATION; INTERFERON PRODUCTION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SUPPRESSOR CELL;

EID: 0031809196     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00165-3     Document Type: Article

References (40)

1. Antel J.P., Arnason B.G.W., Medof M.E. Suppressor cell function in multiple sclerosis: correlation with disease activity. Ann. Neurol. 6:1978;469-473.
2. Antel J.P., Bania M.B., Reder A., Cashman N. Activated suppressor cell dysfunction in progressive multiple sclerosis. J. Immunol. 137:1986;137-141.
3. Baxevanis C.N., Reclos G.J., Ansenis P. Decreased expression of HLA-Dr antigens on monocytes in patients with multiple sclerosis. J. Neuroimmunol. 22:1989;177-183.
4. Baxevanis C.N., Reclos G.J., Papamichail M. Decreased HLA-Dr antigen expression in monocytes causes impaired suppressor cell activity in multiple sclerosis. J. Immunol. 146:1990;4166-4171.
5. Bever C.T., Whitaker J.N. Proteinases in inflammatory demyelinating disease. Springer Seminars in Immunopathology. 8:1985;235-250.
6. Chen W., Zlotnik A. IL-10: a novel cytotoxic T cell differentiation factor. J. Immunol. 147:1991;528-534.
7. Dayal A., Jansen M., Lledo A., Arnason B.G.W. Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta 1b. Neurology. 45:1996;2173-2177.
8. de Waal Malefyt R., Haanen J., Spits H., Roncarolo M.G., te Velde A., Figdor C., Johnson K., Kastelein R., Yssel H., de Vries J.E. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:1991;915-924.
9. de Waal Malefyt R., Abrams J., Bennett B., Figdor C.G., de Vries J.E. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1991;1209-1220.
10. Gallo P., Piccinno M.G., Tavolato B., Sidén Å. A longitudinal study on IL-2, sIL-2R, IL-4 and IFNγ in multiple sclerosis. J. Neurol. Sci. 101:1991;227-232.
11. Genç K., Reder A.T. IFNβ-1b reverses elevated lymphocyte B7 in MS. J. Neuroimmunol. 52(Suppl. 1):1995;20.
12. Giulian D., Lachman L.B. Interleukin-1 stimulation of astroglial proliferation after brain injury. Science. 228:1985;497-499.
13. Hofman F.M.N., von Hanwehr I., Dinarello C.A., Mizel S.B., Hinton D., Merril J.E. Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain. J. Immunol. 136:1986;3239-3245.
14. Hofman F.M., Hinton D.R., Johnson K., Merrill J.E. Tumor necrosis factor identified in multiple sclerosis brain. J. Exp. Med. 170:1989;607-612.
15. Kadish A.S., Tansey F.A., Yu G.S.M., Doyle A.T., Bloom B.R. Interferon as a mediator of human lymphocyte suppression. J. Exp. Med. 151:1980;637-650.
16. Karpus W.J., Gould K.E., Swanborg R.H. CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur. J. Immunol. 22:1992;1757-1763.
17. Klimpel G.R., Infante A.J., Patterson J., Hess C.B., Asuncion M. Virus-induced interferon-α/β (IFN-α/β)production by T cells and by Th1 and Th2 helper Tcell clones: a study of the immunoregulation actions of IFN-α versus IFN-α/β on functions of different T cell populations. Cell Immunol. 128:1990;603-618.
18. Maimone D., Gregory S., Arnason B.G.W., Reder A.T. Cytokine levels in the cerebrospinal fluid and sera of patients with multiple sclerosis. J. Neuroimmunol. 32:1991;67-74.
19. Noma T., Dorf M.E. Modulation of suppressor T cell induction with -interferon. J. Immunol. 135:1985;3655-3660.
20. Noronha A., Toscas A., Jensen M.A. Interferon beta augments suppressor cell function in multiple sclerosis. Ann. Neurol. 27:1990;207-210.
21. Noronha A., Toscas A., Jensen M.A. Interferon-β decreases T cell activation and interferon-γ production in multiple sclerosis. J. Neuroimmunol. 46:1993;145-154.
22. Panitch H.S., Hirsch R.L., Schindler J., Johnson K.P. Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology. 37:1987;1097-1102.
23. Panitch H.S., Folus J.S., Johnson K.P. Recombinant beta interferon inhibits gamma interferon production in multiple sclerosis. Ann. Neurol. 22:1987;139.
24. Porrini A.M., Reder A.T. IFNγ, IFNβ and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis. Cell. Immunol. 157:1994;428-438.
25. Porrini A.M., Gambi D., Reder A.T. Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients. J. Neuroimmunol. 61:1995;27-34.
26. Poser, C.M., Paty, D., Scheinberg, L., Mc Donald, L.W., Davis, F.A., Ebers, G.C., Johnson, K.P., Sibley, W.A., Silberberg, D.H., Tourtellotte, W.W., 1983. New diagnostic criteria for multiple sclerosis. Guidelines for research protocol. In: Poser, C.M. (Ed.), The Diagnosis of Multiple Sclerosis. Thieme-Stratton, Stuttgart/New York, pp. 225-229.
27. Ransohoff R., Tuohy V., Barna B., Rudick R.A. Monocytes in active multiple sclerosis: intact regulation of HLA-DR density in vitro despite decreased HLA-DR density in vivo. J. Neuroimmunol. 37:1992;169-176.
28. Reder, A.T., Arnason, B.G.W., 1985. Immunology of multiple sclerosis. In: Vinken, P.J., Bruyn, G.W., Klawans, H.L., Koetsier, J.C. (Eds.), Handbook of Clinical Neurology, Elsevier Science Publishers, Amsterdam. 3 (47) pp. 337-395.
29. Reder A.T. Regulation of production of adrenocorticotropin-like proteins in human mononuclear cells. Immunology. 77:1992;436-442.
30. Rudick R.A., Carpenter C.S., Cookfair D.L. In vitro and in vivo inhibition of nitrogen-driven T-cell activation by recombinant interferon beta. Neurology. 43:1993;2080-2087.
31. Selmaj K.W., Raine C.S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:1988;339-346.
32. Shakir S., Byskosh P.V., Reder A.T. Interferon-β induces interleukin-10 mRNA in mononuclear cells (MNC). Neurology. 44(Suppl. 2):1994;A211-A212.
33. Sharief M.K., Thompson E.J. Correlation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 56:1993;169-174.
34. + current expression in cultured oligodendrocytes. J. Membrane Biol. 124:1991;127-137.
35. Tada T., Inoue T., Asano Y. Suppression of immune response by cloned T cells and their products. Behring Inst. Mitt. Apr. 91:1992;78-86.
36. The IFNβ multiple sclerosis study group. Sibley, W.A., Ebers, G.C., Panitch, H.S., Reder, A.T., 1993. Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology, 43, 655-661.
37. The IFNβ Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group, 1995. Interferon beta-1b in treatment of multiple sclerosis. Final outcome of the randomized controlled trial. Neurology, 45, 1277-1285.
38. Tilg H., Mier J.W., Vogel W.et al. Induction of circulating IL-1 receptor antagonist by IFN treatment. J. Immunol. 150:1993;4687-4692.
39. Trougott U., Lebon P. Multiple sclerosis: involvement of interferons in lesion pathogenesis. Ann. Neurol. 24:1988;243-251.
40. Yong V.W., Moumdjan R., Yong F.P., Ruijs T.C., Freedman M.S., Cashman N., Antel J.P. Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc. Natl. Acad. Sci. USA. 88:1991;7016-7020.