Physical exertion induces thrombin formation and fibrin degradation in patients with peripheral atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 2, 1998, Pages 244-249

  Mustonen, Pirjo ^a   Lepäntalo, Mauri ^a   Lassila, Riitta ^a,b  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Atherosclerosis; Catecholamines; Coagulation; Exercise; Fibrinolysis

Indexed keywords

ANTIPLASMIN; CATECHOLAMINE; D DIMER; FIBRIN; FIBRINOGEN; LACTIC ACID; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD CLOT LYSIS; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBRINOLYSIS; HUMAN; LEG ISCHEMIA; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL STRESS; PRIORITY JOURNAL; TREADMILL EXERCISE;

EID: 0031809111     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.2.244     Document Type: Article

References (17)

1. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. N Engl J Med. 1993;329:1677-1683.
2. Leor J, Poole W, Kloner R. Sudden cardiac death triggered by an earthquake. N Engl J Med. 1996;334:413-419.
3. Streiff M, Bell WR. Exercise and hemostasis in humans. Semin Hematol. 1994;31:155-165.
4. Lentner C, ed. Geigy Scientific Tables 5, Heart and Circulation. Basel, Switzerland: Ciba-Geigy Ltd; 1990:233-236.
5. Hawkey C, Britton B, Wood W, Peele M, Irving M. Changes in blood catecholamine levels and blood coagulation and fibrinolytic activity in response to graded exercise in man. Br J Haematol. 1975;29:377-384.
6. Kestin A, Ellis P, Barnard M, Errichetti A, Rosner B, Michelson A. Effect of strenuous exercise on platelet activation state and reactivity. Circulation. 1993;88:1502-1511.
7. Eyster ME, Ballard JO, Prager D. Comparison of factor VIII levels after adrenalin in classic hemophilia and von Willebrand's disease (vWd). Thromb Haemost. 1978;39:657-662.
8. Zhu GJ, Abbadini M, Donati MB, Mussoni L. Tissue-type plasminogen activator release in response to epinephrine in perfused rat hindlegs. Am J Physiol. 1989;256:H404-H410.
9. Mustonen P, Lassila R. Epinephrine augments platelet recruitment to immobilized collagen in flowing blood: evidence for a von Willebrand factor-mediated mechanism. Thromb Haemost. 1996;75:175-181.
10. Goto S, Ikeda Y, Murata M, Handa M, Takahashi E, Yoshioka A, Fujimura Y, Fukuyama M, Handa S, Ogawa S. Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation. Circulation. 1992;86:1859-1863.
11. Huisveld IA, van den Burg PJM, Meijer P, van Vliet M, Hospers JEH, Mosterd WL, Bouma BN, Kluft C. Catheter unsuitable for the study of turn-over products of coagulation, fibrinolysis and platelet activation. Fibrinolysis. 1992;6:78-80.
12. Peltonen S, Lassila R, Rossi P, Salenius J-P, Lepäntalo M. Blood coagulation and fibrinolysis activation during sudden arterial occlusion of lower extremities: an association with ischemia and patient outcome. Thromb Haemost. 1995;74:1442-1446.
13. 2-antiplasmin-plasmin complex determination in human plasma. Fibrinolysis. 1992;6(suppl 3):94-96.
14. Kluft C, Verheijen JH. Leiden Fibrinolysis Working Party: blood collection and handling procedures for assessment of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). Fibrinolysis. 1990;4:155-161.
15. Scheinin M, Karhuvaara S, Ojala-Karlsson P, Kallio A, Koulu M. Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor-mediated regulation of norepinephrine release in healthy human volunteers. Life Sci. 1991;49:75-84.
16. Rutherford RB, Flanigan DP, Gupta SK, Johnston KW, Karmody A, Whittemore AD, Baker JD, Ernst CB. Suggested standards for reports, dealing with lower extremity ischemia. J Vasc Surg. 1986;4:80-94.
17. Lassila R, Peltonen S, Lepäntalo M, Saarinen O, Kauhanen P, Manninen V. Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin. Arterioscler Thromb. 1993;13:1412-1417.