Open state block by fendiline of L-type Ca++ channels in ventricular myocytes from rat heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 546-552

  Nawrath, Hermann ^a   Klein, Gunnar ^a   Rupp, Johanna ^a   Wegener, Jörg W ^a   Shainberg, Asher ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; BARIUM ION; CALCIUM CHANNEL; CALCIUM ION; FENDILINE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; FEMALE; HEART MUSCLE CELL; HEART VENTRICLE; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; FEMALE; FENDILINE; HEART; MALE; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

EID: 0031808934     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bayer Rand Mannhold R (1987) Fendiline: A review of its basic pharmacological and clinical properties. Pharmatherapeutica 5:103-36.
2. Bechem M, Goldmann S, Gross R, Hallermann S, Hebisch S. Hutter J, Rounding HP, Schramm M, Stoltefuss J and Straub A (1997) A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines. Life Sci 80:107-118.
3. 2+ channel antagonists. Trends Pharmacol Sci 13:256-262.
4. Cohen NM and Lederer WJ (1987) Calcium current in isolated neonatal rat ventricular myocytes. J Physiol (Lond) 391:169-191.
5. Ehara T and Kaufmann R (1978) The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium. J Pharmacol Exp Ther 207:49-55.
6. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ (1981) Improved patch-clamp techniques for high resolution current recording from cells and cell free membrane patches. Pflügers Arch 391:85-100.
7. Hess P, Lansman JB and Tsien RW (1984) Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311:538-544.
8. Hockermnn GH, Peterson BZ, Johnson BD and Catterall WA (1997) Molecular determinants of drug binding and action on L-type calcium channels. Ann Rev Pharmacol Toxicol 37:361-396.
9. Hondeghem LM and Katzung BG (1984) Antiarrhythmic agents: The modulated receptor mechanism of action of sodium and calcium channel-blocking drugs. Ann Rev Pharmacol Toxicol 24:387-423.
10. Jahnel U, Klemm P and Nawrath H (1994) Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes. Naunyn-Schmiedeberg Arch Pharmacol 349:87-94.
11. Kokubun S and Reuter H (1984) Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proc Natl Acad Sci USA 81:4824-4827.
12. Lee KS and Tsien RW (1983) Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302:790-794.
13. McDonald TF, Pelzer D and Trautwein, W (1980) On the mechanism of slow calcium channel block in heart. Pflügers Arch 385:175-179.
14. McDonald TF, Pelzer D and Trautwein W (1984) Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock. J Physiol (Lond) 352:217-241.
15. McDonald TF, Pelzer S, Trautwein W and Pelzer DJ (1994) Regulation and modulation of calcium channels in cardiac, skeletal and smooth muscle cells. Physiol Rev 74:365-507.
16. Nawrath H and Rupp J (1997) Distinctive effects of fendiline on L-type calcium channels in ventricular myocytes from rat hearts. Biophys J 72:Th-Pos136.
17. Nawrath H and Wegener JW (1997) Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels. Naunyn Schmiedeberg Arch Pharmacol 355:79-86.
18. Pelzer D, Cavalié A and Trautwein W (1985) Guinea-pig ventricular myocytes treated with D600: Mechanism of calcium-channel blockade at the level of single channels, in Recent Aspects in Calcium Antagonism (Lichtlen PR ed) pp 3-26, Schattauer, Stuttgart, FRG.
19. Rakotoarisoa L, Sayet I, Mironneau C and Mironneau J (1990) Selective modulation by membrane potential of desmethoxyverapamil binding to calcium channels in rat portal vein. J Pharmacol Exp Ther 255:942-947.
20. Roberts R and Zanchetti A (1996) Calcium antagonists, in Cardiovascular Drug Therapy (Messerli FH ed) pp 891-901, WB Saunders Company, Philadelphia, PA.
21. Sanguinetti MC and Kass RS (1984) Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 55:336-348.
22. Schreibmayer W, Tripathi O and Tritthart HA (1992) Kinetic modulation of guinea-pig cardiac L-type calcium channels by fendiline and reversal of the effects of Bay K 8644. Br J Pharmacol 106:151-156.
23. +-depolarized smooth muscle. Naunyn Schmiedeberg Arch Pharmacol 328:69-75.
24. Starmer CF, Nesterenko W, Undrovinas AI, Packer DL, Gilliam FR, Grant AO, Rosenshtraukh LV and Strauss HC (1989) Characterizing ion channel blockade with the guarded receptor hypothesis, in Molecular and Cellular Mechanisms of Antiarrhythmic Agents (Hondeghem LM ed) pp 179-200, Future Publ, Comp. Inc., Mount Kisko, NY.
25. Timin EN and Hering S (1992) A method for estimation of drug affinity constants to the open conformational state of calcium channels. Biophys J 63:808-814.
26. Uehara A and Hume JR (1985) Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol 85:621-647.
27. Wegener JW and Nawrath H (1995) Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes. Naunyn Schmiedeberg Arch Pharmacol 352:322-330.
28. Yatani A, Seidel CL, Allen J and Brown AM (1987) Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein. Circ Res 60:523-533.