Gamma-interferon activates a nuclear protein that binds to the gamma- interferon activation site of the thyroglobulin gene

Journal of Molecular Endocrinology

Volumn 20, Issue 3, 1998, Pages 293-298

  Kung, A W C ^a   Lau, K S ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GENE PRODUCT; NUCLEAR PROTEIN; THYROGLOBULIN; THYROTROPIN;

ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; GENE ACTIVATION; GENETIC TRANSCRIPTION; HORMONE METABOLISM; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTERFERON INDUCTION; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; THYROID CELL;

BASE SEQUENCE; BINDING SITES; CELL NUCLEUS; CELLS, CULTURED; DNA FOOTPRINTING; FORSKOLIN; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA, RECOMBINANT; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TATA BOX; THYROGLOBULIN; THYROID GLAND; THYROTROPIN; TRANSFECTION;

EID: 0031808882     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0200293     Document Type: Article

References (27)

1. Ashizama K, Yamashita S, Nagayama Y, Kimura H, Hirayu H, Izume M & Nagataki S 1989 Interferon-γ inhibits thyrotropin-induced thyroidal peroxidase gene expression in cultured human thyrocytes. Journal of Clinical Endocrinology and Metabolism 69 475-477.
2. Bottazzo GF, Pujol-Borrell R, Hanafusa T & Feldmann M 1983 Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2 1115-1119.
3. Christophe D, Cabrer B, Bacolla A, Targovnik H, Pohl V & Vassert G 1985 An unusually long poly(purine) -poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene. Nucleic Acids Research 13 5127-5144.
4. Christophe D, Gerard C, Juvenal G, Bacolla A, Teugels E, Ledent C, Christophe-Hobertus C, Dumont JE & Vassart G 1989 Identification of a cAMP-responsive region in thyroglobulin gene promoter. Molecular and Cellular Endocrinolgy 64 5-18.
5. Civitareale D, Lonigro R, Sinclair A & Di Lauro R 1989 A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO Journal 8 2537-2542.
6. Darnell Jr JE, Kerr IM & Stark GR 1994 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins. Nature 264 1415-1421.
7. Decker T, Lew DJ, Mirkovitch J & Darnell JE 1991 Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. EMBO Journal 10 927-932.
8. Del-Prete GF, Tiri A, Mariotti S, Pinchera A, Ricci M & Romagnani S 1987 Enhanced production of gamma-interferon by thyroid-derived T cell clones from patients with Hashimoto's thyroiditis. Clinical and Experimental Immunology 69 323-331.
9. Dignam JD, Lebovitz RM & Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Research 11 1475-1489.
10. Hamilton F, Black M, Farquharson MA, Stewart C & Foulis AK 1991 Spatial correlation between thyroid epithelial cells expressing class II MHC molecules and interferon-gamma-containing lymphocytes in human thyroid autoimmune disease. Clinical and Experimental Immunology 83 64-68.
11. Hinds WE, Takai N, Rapoport B, Filetti S & Clark OH 1981 Thyroid stimulatory immunoglobulin bioassay using cultured human thyroid cells. Journal of Clinical Endocrinology and Metabolism 52 1204-1210.
12. Igarashi K, David M, Finbloom DS & Larner AC 1993 In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signalling cascade. Molecular and Cellular Biology 13 1634-1640.
13. Khan KD, Shuai K, Lindwall G, Maher SE, Darnell JE & Bothwell ALM 1993 Induction of the Ly-6A/E gene by interferon α/β and γ requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proceedings of the National Academy of Sciences of the USA 90 6806-6810.
14. Kimura S, Hong YS, Kotani T, Ohtaki S & Kikkawa F 1989 Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene. Biochemistry 28 4481-4489.
15. Kung AWC & Lau KS 1990 Interferonγ inhibits thyrotropin-induced thyroglobulin gene transcription in cultured human thyrocytes. Journal of Clinical Endocrinology and Metabolism 70 1512-1517.
16. Kung AWC, Ma L & Lau CS 1992 The role of interferon-gamma in lymphocytic thyroiditis: its functional and pathological effect on human thyrocytes in culture. Clinical and Experimental Immunology 87 261-265.
17. Kung AWC, Lau KS & Wong NS 1995 Interferon-γ increases intracellular calcium and inositol phosphates in primary human thyroid cell culture. Endocrinology 136 5028-5033.
18. Ledent C, Parmentier M & Vassart G 1990 Tissue-specific expression and methylation of a thyroglobulin chloramphenicol acetyltransferase fusion gene in transgenic mice. Proceedings of the National Academy of Sciences of the USA 87 6176-6180.
19. Miller JFAP & Morahan G 1992 Peripheral T cell tolerance. Annual Review of Immunology 10 51-69.
20. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, Pellegrini S, Wilks AF, Ihle JN, Stark GR & Kerr LM 1993 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal tranduction. Nature 366 129-135.
21. Musti AM, Avvedimento EV, Polistina C, Ursini VM, Obici S, Nitsch L, Cocozza S & Di Lauro R 1986 The complete structure of the rat thyroglobulin gene. Proceedings of the National Academy of Sciences of the USA 83 323-327.
22. Nagayama Y, Izumi M, Ashizawa K, Kiriyama T, Kokoyama N, Morita S, Ohtakara S, Fukuda T, Eguchi K & Morimoto I 1987 The inhibitory effect of interferon-gamma on the response of human thyrocytes to TSH stimulation. Journal of Clinical Endocrinology and Metabolism 64 949-959.
23. Nishikawa T, Yamashita S, Namba H, Usa T, Tominaga T, Kimura H, Izumi M & Nagataki S 1993 Interferon-γ inhibition of human thyrotropin receptor gene expression. Journal of Clinical Endocrinology and Metabolism 77 1084-1089.
24. Volpe R 1993 Suppressor T lymphocyte dysfunction is important in the pathogenesis of autoimmune thyroid disease: a perspective. Thyroid 3 345-352.
25. Watson PF, Pickerill AP, Davies R & Weetman AP 1994 Analysis of cytokine gene expression in Graves' disease and multinodular goitre. Journal of Clinical Endocrinology and Metabolism 79 355-360.
26. Weetman AP 1995 Antigen presentation in endocrine autoimmunity. Journal of Autoimmunity 8 305-312.
27. Weetman AP & McGregor AM 1994 Autoimmune thyroid disease: further developments in our understanding. Endocrine Reviews 15 788-830.