Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells

Australian and New Zealand Journal of Ophthalmology

Volumn 26, Issue SUPPL. 1, 1998, Pages

  Zhang, S ^a   Shiels, I A ^a   Ambler, J S ^b   Taylor, S M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Fibronectin; Pirfenidone; Retinal pigment epithelium; Transforming growth factor 1

Indexed keywords

FIBRONECTIN; PIRFENIDONE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL CULTURE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; SYNTHESIS;

EID: 0031807062     PISSN: 08149763     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-9071.1998.tb01380.x     Document Type: Article

References (7)

1. Iyer SN, Wild JS, Scheidt MJ, Hyde DM, Margolin SB, Giri SN. Dietary intake of pirfenidone ameliorates bleomycine-induced lung fibrosis in hamsters. J. Lab. Clin. Med. 1995; 125: 779-85.
2. Margolin SB, Lefkowitz S. Pirfenidone: A novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis. FASEB J. 1995; 18: A382.
3. Jerdan JA, Pepose JS, Michels RG et al. Proliferative vitreo-retinopathy membranes: An immunohistochemical study. Ophthalmology 1989; 96: 801-10.
4. Yamakawa R, Shirakawa H, Okada M, Yoshimura N, Matsumura M, Ogino N. Retinal pigment epithelial cells produce fibronectin. Ophthal. Res. 1987; 19: 338-43.
5. Osusky R, Soriano D, Ye J, Ryan SJ. Cytokine effect on fibronectin release by retinal pigment epithelial cells. Curr. Eye Res. 1994; 13: 569-74.
6. 1 stimulates fibronectin production in bovine adrenocortical cells in culture. J. Biol. Chem. 1990; 265: 6467-72.
7. Wahl SM. Transforming growth factor beta (TGF-β) in inflammation: A cause and a cure. J. Clin. Immunol 1992; 12: 61-74.