Normal myeloid development requires both the glutaminerich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain

Molecular and Cellular Biology

Volumn 18, Issue 7, 1998, Pages 4347-4357

  Fisher, Robert C ^a   Olson, Marilyn C ^b,c   Pongubala, Jagan M R ^a   Perkel, Jeffrey M ^a   Atchison, Michael L ^a   Scott, Edward W ^a   Simon, M Celeste ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c Third Wave Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; EMBRYO; FETUS; GENE CONTROL; HEMATOPOIETIC STEM CELL; MACROPHAGE; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TRANSGENE;

ANIMALIA; VERTEBRATA;

EID: 0031806622     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.4347     Document Type: Article

References (52)

1. Austyn, J., and S. Gordon. 1981. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805-815.
2. Blobel, G. A., C. A. Sieff, and S. H. Orkin. 1995. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol. Cell. Biol. 15:3147-3153.
3. Burkert, U., R. von Ruden, and E. Wagner. 1991. Early fetal hematopoietic development from in vitro differentiated embryonic stem cells. New Biol. 3:698-708.
4. Celada, A., F. E. Borras, C. Soler, J. Lloberas, M. Klemz, C. Vanbeveren, S. McKercher, and R. A. Maki. 1996. The transcription factor PU.1 is involved in macrophage proliferation. J. Exp. Med. 184:61-69.
5. Courey, A. J., and R. Tjian. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898.
6. Doetschman, T., H. Eistetter, M. Katz, W. Schmidt, and R. Kemler. 1985. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands, and myocardium. J. Embryol. Exp. Morphol. 87:27-45.
7. Eisenbeis, C., H. Singh, and U. Storb. 1993. PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin γ2-4 enhancer. Mol. Cell. Biol. 13:6452-6461.
8. Eisenbeis, C. F., H. Singh, and U. Storb. 1995. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 9:1377-1387.
9. Erman, B., and R. Sen. 1996. Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer. EMBO J. 15:4566-4575.
10. Fisher, R. C., and E. W. Scott. 1998. Role of PU.1 in hematopoiesis. Stem Cells 16:25-27.
11. Galson, D., J. Hensold, T. Bishop, M. Schalling, A. D'Andrea, C. Jones, P. Auron, and D. Houseman. 1993. Mouse β-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/Pu.1, and is restricted in expression to hematopoietic cells. Mol. Cell. Biol. 13:2929-2941.
12. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
13. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
14. Hagemeier, C., A. Bannister, A. Cook, and T. Kouzarides. 1993. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc. Natl. Acad. Sci. USA 90:1580-1584.
15. Henkel, G. W., S. R. McKercher, H. Yamamoto, K. L. Anderson, R. G. Oshima, and R. A. Maki. 1996. PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells. Blood 88:2917-2926.
16. Hope, I. A., and K. Struhl. 1986. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46:885-894.
17. Hromas, R., A. Orazi, R. Neiman, R. Maki, C. Van Beveran, J. Moore, and M. Klemsz. 1993. Hematopoietic lineage-and stage-restricted expression of the ETS oncogene family member PU.1. Blood 82:2998-3004.
18. Karim, F. D., L. D. Urness, C. S. Thummel, M. J. Klemsz, S. R. McKercher, A. Celada, C. Van Beveren, R. A. Maki, C. V. Gunther, J. A. Nye, et al. 1990. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev. 4:1451-1453.
19. Keller, G., M. Kennedy, T. Papayannopoulou, and M. Wiles. 1993. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol. Cell. Biol. 13:473-486.
20. Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. USA 89:1473-1476.
21. Klemsz, M., S. McKercher, A. Celada, C. Van Beveren, and R. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the Ets oncogene. Cell 61:113-124.
22. Klemsz, M. J., and A. A. Maki. 1996. Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol. Cell. Biol. 16:390-397.
23. Kodandapani, R., F. Pio, C.-Z. Ni, G. Piccialli, M. Klemz, S. McKercher, R. A. Maki, and K. R. Ely. 1996. A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380:456-480.
24. Kodandapani, R., B. Veerapandian, T. J. Kunicki, and K. R. Ely. 1995. Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site. J. Biol. Chem. 270:2268-2273.
25. Kominato, Y., D. Galson, W. R. Waterman, A. C. Webb, and P. E. Auron. 1995. Monocyte expression of the human prointerleukin 1β gene (IL1B) is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1. Mol. Cell. Biol. 15:58-68.
26. Luscher, B., and R. N. Eisenman. 1998. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock. Mol. Cell. Biol. 8:2504-2512.
27. Ma, J., and M. Ptashne. 1987. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847-853.
28. Matsuyama, T., R. A. Grossman, H. W. Mittrucker, D. P. Siderovski, F. Kiefer, T. Kawakami, C. D. Richardson, T. Taniguchi, S. K. Yoshinaga, and T. W. Mak. 1995. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res. 23:2127-2136.
29. Mittrucker, H. W., T. Matsuyama, A. Grossman, T. M. Kundig, J. Potter, A. Shahinian, A. Wakeham, B. Patterson, P. S. Ohashi, and T. W. Mak. 1997. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275:540-543.
30. Moreau-Gachelin, F., D. Ray, M. Mattel, P. Tambourin, and A. Tavitian. 1989. The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene 4:1449-1456.
31. Nagulapalli, S., J. Pongubala, and M. Atchison. 1995. Multiple proteins physically interact with PU.1. J. Immunol. 155:4330-4338.
32. Olson, M., E. W. Scott, A. Hack, G. Su, H. Singh, and M. C. Simon. 1995. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 3:702-714.
33. Olweus, J., P. A. Thompson, and F. Lund-Johnson. 1996. Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1-regulated molecules, CD64 and macrophage colony-stimulating factor receptor. Blood 88:3741-3754.
34. Perkel, J. M., and M. L. Atchison. 1997. Personal communication.
35. Pongubala, J., S. Nagulapalli, M. Klemsz, S. McKercher, R. Maki, and M. Atchison. 1992. PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity. Mol. Cell. Biol. 12:368-378.
36. Pongubala, J., C. Van Beveren, S. Nagulapalli, M. Klemsz, S. McKercher, R. Maki, and M. Atchison. 1993. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259:1622-1625.
37. Pongubala, J. M., and M. L. Atchison. 1991. Functional characterization of the developmentally controlled immunoglobulin kappa 3′ enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors. Mol. Cell. Biol. 11:1040-1047.
38. Pongubala, J. M., and M. L. Atchison. 1997. PU.1 can participate in an active enhancer complex without its transcriptional activation domain. Proc. Natl. Acad. Sci. USA 94:127-132.
39. Rechsteiner, M., and S. W. Rogers. 1996. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21:267-271.
40. Roeder, R. G. 1996. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21:327-335.
41. Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234: 364-368.
42. Rosmarin, A., S. Weil, G. Rosner, J. Griffin, M. Arnaout, and D. Tenen. 1989. Differential expression of CD11b/CD18 (Mol) and myeloperoxidase genes during myeloid differentiation. Blood 73:131-136.
43. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL-4 VP16 is an unusually potent transcriptional activator. Nature 335:563-564.
44. Schmitt, R., E. Bruyns, and H. Snodgrass. 1991. Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes Dev. 5:728-740.
45. Schuetze, S., P. Stenberg, and D. Kabat. 1993. The ETS-related transcription factor PU.1 immoralizes erythroblasts. Mol. Cell. Biol. 13:5670-5678.
46. Scott, E. W., R. Fisher, M. Olson, M. C. Simon, and H. Singh. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6:437-447.
47. Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573-1577.
48. Shin, M., and M. Koshland. 1993. Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev. 7:2006-2015.
49. Weiss, M. J., C. Yu, and S. H. Orkin. 1997. Erythroid-cell-specific properties of transcription GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17:1642-1651.
50. Wiles, M., and G. Keller. 1991. Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111:259-267.
51. Yamada, T., N. Kondoh, M. Matsumoto, M. Yoshida, A. Maekawa, and T. Oikawa. 1997. Overexpression of PU.1 induces growth and differentiation inhibition and apoptotic cell death in murine erythroleukemia cells. Blood 89:1383-1393.
52. Yamagata, T., J. Nishida, S. Tanaka, R. Sakai, K. Mitani, M. Yoshida, T. Taniguchi, Y. Yazaki, and J. Hirai. 1996. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol. Cell. Biol. 16:1283-1294.