Inhibitory effects of pentoxifylline on ultraviolet B light-induced cutaneous inflammation

Molecular Carcinogenesis

Volumn 22, Issue 1, 1998, Pages 16-25

  Oberyszyn, Tatiana M ^a,b   Tober, Kathleen L ^a   Ross, Mary S ^a   Robertson, Fredika M ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Cytokines; Epidermis; Inflammation; Tumor necrosis factor

Indexed keywords

CYTOKINE; MYELOPEROXIDASE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CORNEA CELL; GENE EXPRESSION REGULATION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CELL; SKIN INFLAMMATION; ULTRAVIOLET B RADIATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIVISION; INFLAMMATION; MICE; MICE, INBRED HRS; NEUTROPHILS; PENTOXIFYLLINE; PEROXIDASE; PROLIFERATING CELL NUCLEAR ANTIGEN; RADIATION INJURIES, EXPERIMENTAL; SKIN; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

EID: 0031805811     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199805)22:1<16::AID-MC3>3.0.CO;2-J     Document Type: Article

References (71)

1. + dendritic epidermal cells in murine epidermis during the evolution of radiation-induced skin cancers. Cancer Res 49:4591-4596, 1991.
2. Kripke ML. Immunological effects of ultraviolet radiation. J Dermatol 18:429-433, 1991.
3. Baadsgaard O. In vivo ultraviolet irradiation of human skin results in profound perturbation of the immune system: Relevance to ultraviolet-induced skin cancer. Arch Dermatol 127:99-109, 1991.
4. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 158:781-794, 1983.
5. Cruz P, Bergstresser P. Ultraviolet radiation, Langerhans' cells, and skin cancer: Conspiracy and failure. Arch Dermatol 125:975-979, 1989.
6. Choi KL, Sauder DN. The role of Langerhans cells and keratinocytes in epidermal immunity. J Leukoc Biol 39:343-358, 1986.
7. Kupper TS. Mechanisms of cutaneous inflammation. Arch Dermatol 125:1406-1412, 1989.
8. Robertson FM, Bijur GN, Oberyszyn AS, et al. Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion. Carcinogenesis 15:1017-1029, 1994.
9. Oberyszyn TM, Sabourin CLK, Bijur GN, Boros LG, Oberyszyn AS, Robertson FM. Interleukin-1α gene expression and localization of interleukin-1α protein during tumor promotion. Mol Carcinog 7:238-248, 1993.
10. Rivas JM, Ullrich SE. The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation. J Leukoc Biol 56:769-775, 1994.
11. Kapas L, Hong L, Cady AB, et al. Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-α and TNF-α fragments. Am J Physiol 263(3 pt 2):R708-715, 1992.
12. Camussi G, Albano E, Tetta C, Bussolino F. The molecular action of tumor necrosis factor-α. Eur J Biochem 202:3-14, 1991.
13. Kock A, Schwarz T, Kirnbauer R, et al. Human keratinocytes are a source for tumor necrosis factor alpha: Evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-1614, 1990.
14. Vincek V, Kurimoto I, Medema JP, Prieto E, Streilein JW. Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity. Cancer Res 53:728-732, 1993.
15. Rivas JM, Ullrich SE. Systemic suppression of delayed type hypersensitivity by supernatants from UV irradiated keratinocytes: An essential role for keratinocyte-derived IL-10. J Immunol 149:3865-3871, 1992.
16. Yoshikawa T, Streilein JW. On the genetic basis of the effects of ultraviolet light B on cutaneous immunity: Evidence that polymorphism at the TNF-α and Lps loci govern susceptibility. Immunogenetics 32:398-405, 1990.
17. Haniszko J, Suskind RR. The effect of ultraviolet radiation on experimental cutaneous sensitization in guinea pigs. J Invest Dermatol 40:183-191, 1963.
18. Sullivan GW, Carper HT, Novick WJ, Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun 56:1722-1729, 1988.
19. Williams JH Jr, Heshmati S, Tamadon S, Guerra J. Inhibition of alveolar macrophages by pentoxifylline. Crit Care Med 19:1073-1078, 1991.
20. Hammerschmidt DE, Kotasek D, McCarthy T, Huh P-W, Freyburger G, Vercellotti GM. Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. J Lab Clin Med 112:254-263, 1988.
21. Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med 172:391-394, 1990.
22. Waage A, Sorenson M, Stordal B. Differential effect of oxpentifylline on tumour necrosis factor and interleukin-6 production. Lancet 335:543, 1990.
23. Piguet PF, Grau GE, Hauser C, Vassalli P. Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions. J Exp Med 173:673-679, 1991.
24. Schwarz A, Krone C, Trautinger F, et al. Pentoxifylline suppresses irritant and contact hypersensitivity reactions. J Invest Dermatol 101:549-552, 1993.
25. Mandell GL, Novick WJ Jr (eds). Proceedings of a Symposium: Pentoxifylline and Leukocyte Function. Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ, 1988.
26. Bessler HR, Gilgal M, Djaldetti M, Zahavi I. Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J Leukoc Biol 40:747-754, 1986.
27. Crouch SPM, Fletcher J. Effect of ingested pentoxifylline on neutrophil superoxide anion production. Infect Immun 60:4504-4509, 1992.
28. Freitas JP, Filipe PM. Pentoxifylline: A hydroxyl radical scavenger. Biol Trace Elem Res 47:307-311, 1995.
29. Hestdal K, Ruscetti FW, Ihle JN, et al. Characterization and regulation of RB6-8 C5 antigen expression on murine bone marrow cells. J Immunol 147:22-28, 1991.
30. Spangrude GJ, Helfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 241:58-62, 1988.
31. Barmann TE. Enzyme Handbook, Vol I. Springer Verlag, New York, 1969, pp. 234-235.
32. Nill MR, Oberyszyn TM, Ross MS, Oberyszyn AS, Robertson FM. Temporal sequence of pulmonary cytokine gene expression in response to endotoxin in C3H/HeN endotoxin-sensitive and C3H/ HeJ endotoxin-resistant mice. J Leukoc Biol 58:563-574, 1995.
33. Murphy E, Hieny S, Sher A, O'Garra A. Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Shistosoma mansoni infected mice. J Immunol Methods 162:211-223, 1993.
34. Lannard P. Image analysis for all. Nature 347:103-104, 1990.
35. O'Neil R. Use of image analysis to quantitate changes in form of mitochondrial DNA after X-irradiation. Appl Theor Electrophor 1:163-167, 1989.
36. Sundfors C, Collan Y. Basics of quantitative PCR: Image analysis and quantitation of PCR products. Cell Mol Biol 41:671-681, 1995.
37. Kupper TS. The second decade of epidermal cytokine: An overview. In: Luger TA, Schwarz T (eds), Epidermal Growth Factors and Cytokines. Marcel Dekker, New York, 1993, p. 293.
38. Schwarz T, Luger TA. Pharmacology of cytokines in the skin. In: Mukhtar H (ed), Pharmacology of the Skin. CRC Press, Boca Raton, FL, 1992, p. 283.
39. Robertson FM, Bijur GN, Oberyszyn AS, et al. Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion. Carcinogenesis 15:1017-1029, 1994.
40. Kodari E, Pavone A, Reiners JJ Jr. Differential modulation of contact hypersensitivity and delayed hypersensitivity reactions by topical application of 12-O-tetradecanoylphorbol-13-acetate. Immunopharmacol Immunotoxicol 15:639-647, 1993.
41. Rivas JM, Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from ultraviolet irradiated keratinocytes: An essential role for keratinocyte-derived IL-10. J Immunol 149:3865-3871, 1992.
42. Enk AH, Katz SI. Identification and induction of keratinocyte-derived IL-10. J Immunol 149:92-95, 1992.
43. Kupper T. The role of epidermal cytokines. In: Oppenheim JJ, Shevach E (eds), The Immunophysiology of Cells and Cytokines. Oxford University Press, New York, 1990, p. 285.
44. Kock A, Schwarz T, Kirnbauer R, et al. Human keratinocytes are a source for tumor necrosis factor alpha: Evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-1614, 1990.
45. Woodley DT, Bachman PM, O'Keefe EJ. The role of matrix components in human keratinocyte re-epithelialization. In: Barbul A, Caldwell MD, Eaglstein WH, et al., Clinical and Experimental Approaches to Dermal and Epidermal Repair: Normal and Chronic Wounds. Wiley-Liss, New York, 1991, pp. 129-140.
46. Smola H, Thiekotter G, Fusenig NE. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J Cell Biol 122:417-429, 1993.
47. Berman B, Duncan MR. Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma, and morphoea skin and their production of collagen, glycosaminogly-cans, and fibronectin. Br J Dermatol 123:339-346, 1990.
48. Robertson FM, Ross MS, Tober KL, Long BW, Oberyszyn TM. Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline. Carcinogenesis 17:1719-1728, 1996.
49. Kripke ML. Immunological unresponsiveness induced by ultraviolet radiation. Immunol Rev 80:87-102, 1984.
50. Daynes RA, Spellman CW, Woodward JG, Stewart DA. Studies into the transplantation biology of ultraviolet light-induced tumors. Transplantation 23:343-348, 1977.
51. Noonan FP, De Fabo EC, Kripke ML. Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity. Photochem Photobiol 34:683-689, 1981.
52. Morison WL, Kripke ML. Systemic suppression of contact hypersensitivity by UVB radiation of methoxsalen/ultraviolet a radiation in the guinea pig. Cell Immunol 85:270-277, 1984.
53. Morison WL, Pike RA, Kripke ML. Effect of sunlight and its component wavebands on contact hypersensitivity in mice and guinea pigs. Photodermatology 2:195-204, 1985.
54. Ullrich SE, Azizi E, Kripke ML. Suppression of the induction of delayed-type hypersensitivity reactions in mice by a single exposure to ultraviolet radiation. Photochem Photobiol 43:633-638, 1986.
55. Ullrich SE. Suppression of the immune response to allogeneic histocompatibility antigen by a single exposure to ultraviolet radiation. Transplantation 42:287-291, 1986.
56. Yoshikawa T, Streilein JW. Tumor necrosis factor-alpha and ultraviolet B light have similar effects on contact hypersensitivity in mice. Regional Immunology 3:139-144, 1990-1991.
57. Kono T, Tanii T, Furukawa M, et al. Effects of human recombinant tumor necrosis factor-alpha (TNF-alpha) on the proliferative potential of human keratinocytes cultured in serum-free medium. J Dermatol 17:409-413, 1990.
58. Mosmann TR, Moore KW. The role of IL-10 in crossregulation of Th1 and Th2 responses. Immunol Today 12:A49-53, 1993.
59. Anderson C, Elmets C. Evidence that cytokines are important mediators for UVB effects in skin tumorigenesis (abstract). Proceedings of the American Association for Cancer Research 37:452, 1996.
60. Schwarz A, Aragene Y, Simon M, Luger TA, Schwarz T. Pentoxifylline (PTX) suppresses UVB-induced cytokine release by keratinocytes. J Invest Dermatol 101:388, 1993.
61. Strieter RM, Remick DG, Ward RN, et al. Cellular and molecular regulation of tumor necrosis factor alpha production by pentoxifylline. Biochem Biophys Res Commun 155:1230-1236, 1988.
62. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 110:192-198, 1991.
63. Schandene L, Vandenbussche P, Crusizux A, et al. Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by monocytes and T cells. Immunology 76:30-34, 1992.
64. Wang P, Ba ZF, Morrison MH, Ayala A, Chaudry IH. Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation. Surgery 112:451-458, 1992.
65. Oberyszyn TM, Pellegrini AE, Robertson FM. Pentoxifylline-mediated alterations of ultraviolet light induced cutaneous inflammation (abstract). Proceedings of the American Association for Cancer Research 35:644, 1994.
66. Movat HZ, Cybulsky MI, Coldit IG, Chan MKW, Dinarello CA. Acute inflammation in gram-negative infection: Endotoxin, interleukin 1, tumor necrosis factor, and neutrophils. Federation Proceedings 46:97-104, 1987.
67. Wei H, Grenkel K. Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by Sarcophytol A: A possible mechanism of antipromotion. Cancer Res 52:2298-2303, 1992.
68. Frenkel K, Wei H, Bhimani R, Ye J, et al. Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res 53:1255-1261, 1993.
69. Trush MA, Egner PA, Kensler TW. Myeloperoxidase as a biomarker of skin irritation and inflammation. Food Chem Toxicol 32:143-147, 1994.
70. Sullivan GW, Luong LS, Carper HT, Barnes RC, Mandell GL. Methylxanthines with adenosine alter TNF alpha-primed PMN activation. Immunopharmacology 31:19-29, 1995.
71. Elbim C, Lefebvre M, Hakim J, Gougerot-Pocidalo MA. Effects of pentoxifylline on human polymorphonuclear neutrophil responses to TNF in whole blood. Eur Cytokine Netw 6:113-120, 1995.