Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats

Journal of Toxicological Sciences

Volumn 23, Issue 2, 1998, Pages 129-148

  Sadanobu, Shinro ^a   Takeuchi, Masaya ^b   Tezuka, Masakatsu ^a  

^a NIHON UNIVERSITY   (Japan)

^b Sapporo Gen Pathol Lab Co   (Japan)

Author keywords

Carbon tetrachloride; D galactosamine; Hepatoprotective effect; Rat; Thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CHOLESTEROL; CYCLOPENTENE DERIVATIVE; GALACTOSAMINE; GAMMA GLUTAMYLTRANSFERASE; LIVER PROTECTIVE AGENT; OLIVE OIL; THIOACETAMIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER INJURY; LIVER PROTECTION; LIVER WEIGHT; LONG TERM EXPOSURE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0031805543     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.23.2_129     Document Type: Article

References (25)

1. Allain, C.C., Poon, L.S., Chan, C.S.G., Richmond, W. and Fu, P.C. (1974): Enzymatic determination of total serum cholesterol. Clin. Chem., 20, 470-475
2. Ambrose, A.M., DeEds, F. and Rather L.J. (1949): Toxicity of thioacetamide in rats. J. Ind. Hyg. Toxicol., 31, 158-161
3. Challenger, F., Mason, E.A., Holdsworth, E.C. and Emmott, R. (1952): Isomeric dithiacyclopentenethiones. Chemistry & Industry, 714
4. Dashti, H., Jeppsson, B., Hagerstr and, L, Hultberg, B., et al. (1989): Thioacetamide-and carbon tetrachloride-induced liver cirrhosis. Eur. Surg. Res., 21, 83-91
5. Decker K. and Keppler D. (1972): Galactosamine-induced liver injury; in Popper H and Schaffner F. (eds): Progress in liver disease. New York, Grune & Stratton, vol. 4, 183-199
6. Dunnett C. W. (1964): New tables for multiple comparisons with a control. Biometrics, 20, 482-491
7. Fitzhugh O.G., Nelson, A.A. (1948): Liver tumors in rats fed thiourea or thioacetamide. Science, 108, 626-628
8. Fujisawa, K., Tanaka, M., Amamiya, K., Sen, K. et al. (1986): The effect of protease, proteolytic enzyme, upon experimental liver disorders induced by combined administration of D-galactosamine and carbon tetrachloride., Jpn. Clin. Exp. Med., 63, 324-332
9. Grun, M., Liehr, H. and Rasenack. U. (1976): Significance of endotoxaemia in experimental "Galactosamine hepatitis" in the rat. Acta HepatoGastroenterol., 23, 64-81
10. Iwaki, Y., Noguchi, K., Abe, H., Tanikawa, K. and Tsuda, K. (1988): Role of endotoxin in D-galactosamine induced hepatic injury. Acta Hepatol. Jpn., 29, 1043-1050
11. Karmen, A., Wroblewski, F. and La Due, J.S. (1955): Transaminase activities in human blood. J. Clin. Invest., 34, 126-131
12. Katoh, M. and Sugimoto, T. (1982): Effect of malotilate on chronic liver injury induced by carbon tetrachloride in rats. Folia Pharmacol. Japon, 80, 83-91
13. Keppler, D., Lesch. R., Reutter, W., & Decker, D. (1968): Experimental hepatitis induced by D-galactosamine. Exp. Mol. Path. 9, 279-290
14. Keppler, D., Rudigier, J., Bischoff, E., and Decker, K. (1970): The trapping of uridine phosphates by D-galactosamine, D-glucosamine and 2-deoxy-D-galactose. Eur. J. Biochem., 17, 246-253
15. Kind, P.R.N. and King, E.J. (1954): Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J. Clin. Path., 7, 322-326
16. Nuber, R., Teutsch, H.F., and Sasse, D. (1980): Metabolic zonation in thioacetamide-induced liver cirrhosis. Histochemistry, 69, 277-288
17. 35S in the intact rat. Cancer Res., 14, 625-628
18. Orlowski, M. and Meister, A. (1963): γ -Glutamyl-p-nitro-anilide, a new convetivities substrate for determination and study of L-and D-γ -glutamyl transpeptidase activities. Biochem. Biophys. Acta, 73, 679
19. Sadanobu, S., Takeuchi, M. and Tezuka, M. (1997): Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats. J. Toxicol. Sci., 22, 413-426
20. Saga, K., Sato, N. and Amamiya, K. (1988): Quantitative method using carmine dye for measuring the volume of blood vessels in the liver and capillaries developing effect of pronase in experimentally chronic liver lesion induced by D-galac-tosamine plus carbon tetrachloride. Basic Pharmacol. Ther., 16(8), 67-70
21. Sato, Y., Koyama, K., Asanuma, Y, Omokawa, S. et al. (1990): Cell kinetic studies on the experimental liver cirrhosis induced by thioacetamide in the rat. Acta Hepatol. Jpn. 31, 280-286
22. Spayd, R.W., Bruschl, B., Burdick, B.A., Dappen, G.M., et al., (1978): Multilayer film elements for clinical analysis: Applications to representative chemical determinations. Clin. Chem., 24, 1343-1350
23. Umezu, K., Yuasa, S. and Sudoh, A. (1985): Antidotal properties of tritoqualine against liver injury by some toxic agents in rats. Pharmacometrics, 29, 381-389
24. Wendel, A., Tiegs, G., and Werner, C (1987): Evidence for the involvement of reperfusion injury in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmacol. 36, 2637-2639
25. Wroblewski, F. and La Due, J.S. (1956): Serum glutamic pyruvic transaminase in cardiac and hepatic disease. Proc. Soc. Exp. Biol. Med., 91, 569-571