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Volumn 9, Issue 6, 1998, Pages 455-463

Recombinant plasminogen activators: A comparative review of the clinical pharmacology and therapeutic use of alteplase and reteplase

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; ANISTREPLASE; HEPARIN; RECOMBINANT PLASMINOGEN ACTIVATOR; RETEPLASE; STREPTOKINASE; UROKINASE;

EID: 0031804199     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199809060-00003     Document Type: Review
Times cited : (3)

References (31)
  • 1
    • 0022640774 scopus 로고
    • Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction
    • Feb 22
    • GISSI (Gruppo Italiano per lo Studio della Streptokinasi nell'Infarto myocardico). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986 Feb 22: 1: 397-402
    • (1986) Lancet , vol.1 , pp. 397-402
  • 2
    • 0020472522 scopus 로고
    • Kinetics of the activation of plasminogen by human tissue plasminogen activator: Role of fihrin
    • Hoylaerts M, Rijken DC, Lijnen HR, et al. Kinetics of the activation of plasminogen by human tissue plasminogen activator: role of fihrin. J Biol Chem 1982; 257: 2912-9
    • (1982) J Biol Chem , vol.257 , pp. 2912-2919
    • Hoylaerts, M.1    Rijken, D.C.2    Lijnen, H.R.3
  • 3
    • 0026575312 scopus 로고
    • Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022
    • Kohnert U, Rudolph R, Verheijen JH, et al. Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022. Protein Eng 1992; 5: 93-100
    • (1992) Protein Eng , vol.5 , pp. 93-100
    • Kohnert, U.1    Rudolph, R.2    Verheijen, J.H.3
  • 4
    • 0027400526 scopus 로고
    • Differential fibrinolytic properties of the recombinant plasminogen activator BM 06.022 in human plasma and blood clot systems in vitro
    • Martin U, Sponer G, Strein K. Differential fibrinolytic properties of the recombinant plasminogen activator BM 06.022 in human plasma and blood clot systems in vitro. Blood Coagul Fibrinol 1993; 4: 235-42
    • (1993) Blood Coagul Fibrinol , vol.4 , pp. 235-242
    • Martin, U.1    Sponer, G.2    Strein, K.3
  • 5
    • 0024381603 scopus 로고
    • Serpin-resistant mutants of human tissue type plasminogen activator
    • Madison EL, Goldsmith EJ, Gerard RD, et al. Serpin-resistant mutants of human tissue type plasminogen activator. Nature 1989; 339: 721-3
    • (1989) Nature , vol.339 , pp. 721-723
    • Madison, E.L.1    Goldsmith, E.J.2    Gerard, R.D.3
  • 6
    • 0026557133 scopus 로고
    • Pharmacokinetics of the novel recombinant plasminogen activator BM 06.022 in rats, dogs, and nonhuman primates
    • Martin U, Köhler J, Sponer G, et al. Pharmacokinetics of the novel recombinant plasminogen activator BM 06.022 in rats, dogs, and nonhuman primates. Fibrinolysis 1992; 6: 39-43
    • (1992) Fibrinolysis , vol.6 , pp. 39-43
    • Martin, U.1    Köhler, J.2    Sponer, G.3
  • 7
    • 0027057301 scopus 로고
    • Bolus application of a novel recombinant plasminogen activation in acute myocardial infarction patients: Pharmacokinetics and effect on the hemostatic system
    • Seifried E, Mueller M, Martin U, et al. Bolus application of a novel recombinant plasminogen activation in acute myocardial infarction patients: pharmacokinetics and effect on the hemostatic system. Ann NY Acad Sci 1991; 667: 417-20
    • (1991) Ann NY Acad Sci , vol.667 , pp. 417-420
    • Seifried, E.1    Mueller, M.2    Martin, U.3
  • 8
    • 0025829182 scopus 로고
    • Thrombolysis with an Escherichia coli-produced recombinant plasminogen activator (BM 06.022) in the rabbit model of jugular vein thrombosis
    • Martin U, Fischer S, Kohnert U, et al. Thrombolysis with an Escherichia coli-produced recombinant plasminogen activator (BM 06.022) in the rabbit model of jugular vein thrombosis. Thromb Haemost 1991; 65: 560-4
    • (1991) Thromb Haemost , vol.65 , pp. 560-564
    • Martin, U.1    Fischer, S.2    Kohnert, U.3
  • 9
    • 0026595548 scopus 로고
    • Evaluation of thrombolytic and systemic effects of thec novel recombinant plasminogen activator BM 06.022 compared with alteplase, anistreplase, streptokinase, and urokinasc in a canine model of coronary artery thrombosis
    • Martin U, Sponer G, Strein K. Evaluation of thrombolytic and systemic effects of thec novel recombinant plasminogen activator BM 06.022 compared with alteplase, anistreplase, streptokinase, and urokinasc in a canine model of coronary artery thrombosis. J Am Coll Carcdiol 1992; 19: 433-40
    • (1992) J Am Coll Carcdiol , vol.19 , pp. 433-440
    • Martin, U.1    Sponer, G.2    Strein, K.3
  • 10
    • 0026699823 scopus 로고
    • Hirudin and solutroban improve coronary blood flow after reperfusion induced by the novel recombinant plasminogen activator BM 06.022 in a canine model of coronary artery thrombosis
    • Martin U, Sponer G, Strein K. Hirudin and solutroban improve coronary blood flow after reperfusion induced by the novel recombinant plasminogen activator BM 06.022 in a canine model of coronary artery thrombosis. J Int Haematol 1992; 56: 143-53
    • (1992) J Int Haematol , vol.56 , pp. 143-153
    • Martin, U.1    Sponer, G.2    Strein, K.3
  • 11
    • 0021916187 scopus 로고
    • The Trombolysis in Myocardial Infarction (TIMI) trial: phase I results
    • TIMI Study Group. The Trombolysis in Myocardial Infarction (TIMI) trial: phase I results N Engl J Med 1985; 312: 932-6
    • (1985) N Engl J Med , vol.312 , pp. 932-936
  • 12
    • 0028337135 scopus 로고
    • Dose finding with a novel recombinant plasminogen activator (BM 06.022) in patients with acute myocardial infarction: Results of the German Recombinant Plasminogen Activator Study
    • Neuhaus KL, von Essen R, Vogt A, et al. Dose finding with a novel recombinant plasminogen activator (BM 06.022) in patients with acute myocardial infarction: results of the German Recombinant Plasminogen Activator Study. J Am Coll Cardiol 1994; 24: 55-60
    • (1994) J Am Coll Cardiol , vol.24 , pp. 55-60
    • Neuhaus, K.L.1    Von Essen, R.2    Vogt, A.3
  • 13
    • 0027203680 scopus 로고
    • Open, non-controlled dose-finding study with a novel plasminogen activator (BM 06.022) given as a double bolus in patients in patients with acute myocardial infarction
    • Tebbe U, von Essen R, Smolarz A, et al. Open, non-controlled dose-finding study with a novel plasminogen activator (BM 06.022) given as a double bolus in patients in patients with acute myocardial infarction. Am J Cardiol 1993; 72: 518-24
    • (1993) Am J Cardiol , vol.72 , pp. 518-524
    • Tebbe, U.1    Von Essen, R.2    Smolarz, A.3
  • 14
    • 0029066701 scopus 로고
    • More rapid, complete, andi stable coronary thrombosis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction
    • Smalling RW, Bode C, Kalbfleisch J, RAPID Investigators, et al. More rapid, complete, andi stable coronary thrombosis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction. Circulation 1995; 91: 2725-32
    • (1995) Circulation , vol.91 , pp. 2725-2732
    • Smalling, R.W.1    Bode, C.2    Kalbfleisch, J.3
  • 15
    • 1842353065 scopus 로고
    • Improvement of global and regional LV-function by the bolus administration of recombinant plasminogen activator (r-PA) in acute myocardial infarction: A comparison with standard dose alteplase
    • Smalling RW, Bode C, Kalbfleisch J, RAPID Investigators, et al. Improvement of global and regional LV-function by the bolus administration of recombinant plasminogen activator (r-PA) in acute myocardial infarction: a comparison with standard dose alteplase [abstract]. Calculation 1994; 90 Suppl 1: 562
    • (1994) Calculation , vol.90 , Issue.1 SUPPL. , pp. 562
    • Smalling, R.W.1    Bode, C.2    Kalbfleisch, J.3
  • 16
    • 1842272222 scopus 로고
    • Safety profile of reteplase (r-PA) as compared to alteplase (rt-PA): Will there be fewer strokes?
    • Bode C, Smalling RW, Sen S, RAPID Investigators, et al. Safety profile of reteplase (r-PA) as compared to alteplase (rt-PA): will there be fewer strokes [abstract]? Eur Heart J 1994; 15 Suppl.: 3096
    • (1994) Eur Heart J , vol.15 , Issue.SUPPL. , pp. 3096
    • Bode, C.1    Smalling, R.W.2    Sen, S.3
  • 17
    • 0029142436 scopus 로고
    • Randomized, double-blind comparison of reteplase double bolus administration with streptokinase in acute myocardial infarction (INJECT): Trial to investigate equivalence
    • International Joint Efficacy Comparison of Thrombolytics. Randomized, double-blind comparison of reteplase double bolus administration with streptokinase in acute myocardial infarction (INJECT): trial to investigate equivalence: Lancet 1995; 346: 329-36
    • (1995) Lancet , vol.346 , pp. 329-336
  • 18
    • 0027240597 scopus 로고
    • An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction
    • GUSTO (Global Utilisation of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries). An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993; 329: 673-82
    • (1993) N Engl J Med , vol.329 , pp. 673-682
  • 19
    • 0343849937 scopus 로고    scopus 로고
    • Randomized comparison of coronary thrombolysis achieved with double-bolus rereplase recombinant plasminogen activator and front-loaded, accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute invocardial infarction
    • Bode C, Smalling RW, Berg G, RAPID 2 Investigators, et al. Randomized comparison of coronary thrombolysis achieved with double-bolus rereplase (recombinant plasminogen activator and front-loaded, accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute invocardial infarction. Circulation 1996; 84: 891-8
    • (1996) Circulation , vol.84 , pp. 891-898
    • Bode, C.1    Smalling, R.W.2    Berg, G.3
  • 20
    • 0030879325 scopus 로고    scopus 로고
    • A comparison of reteplase with alleplase for acute myocardial infarction
    • GUSTO-III. A comparison of reteplase with alleplase for acute myocardial infarction. N Engl J Med 1997; 337: 1118-23
    • (1997) N Engl J Med , vol.337 , pp. 1118-1123
  • 21
    • 0026653385 scopus 로고
    • Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in mycardial infarction
    • Carney RJ, Murphy GA, Brand TR, et al. Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in mycardial infarction. J Am Coll Cardiol 1992; 52: 17-23
    • (1992) J Am Coll Cardiol , vol.52 , pp. 17-23
    • Carney, R.J.1    Murphy, G.A.2    Brand, T.R.3
  • 22
    • 0026522895 scopus 로고
    • Improved thrombolysis in acute myocardial infarction with front-loaded administration of alteplase: Results of the rt-PA APSAC patency study (TAPS)
    • Neuhaus KL, von Essen R, Tebbe U, et al. Improved thrombolysis in acute myocardial infarction with front-loaded administration of alteplase: results of the rt-PA APSAC patency study (TAPS). J Am Coll Cardiol 1992; 19: 855-91
    • (1992) J Am Coll Cardiol , vol.19 , pp. 855-891
    • Neuhaus, K.L.1    Von Essen, R.2    Tebbe, U.3
  • 23
    • 0027424433 scopus 로고
    • The comparative effects of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function and survival in acute myocardial infarction
    • GUSTO Angiographic Investigators. The comparative effects of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function and survival in acute myocardial infarction. N Engl J Med 1993; 329: 1615-22
    • (1993) N Engl J Med , vol.329 , pp. 1615-1622
  • 24
    • 0027245839 scopus 로고
    • Impact of early reperfusion status of the infarct-related artery on short-term mortality aftet thrombolysis for acute myocardial infarction: Comparative analysis of four German multicenter studies
    • Vogt A, von Essen R, Tebbe U, et al. Impact of early reperfusion status of the infarct-related artery on short-term mortality aftet thrombolysis for acute myocardial infarction: comparative analysis of four German multicenter studies. J Am Coll Cardiol 1993; 21: 1391-5
    • (1993) J Am Coll Cardiol , vol.21 , pp. 1391-1395
    • Vogt, A.1    Von Essen, R.2    Tebbe, U.3
  • 25
    • 0026569906 scopus 로고
    • Does Thrombolysis in Myocardial Infarction (TIMi) perfusion grade 2 represent a mostly patent artery or a mostly occluded artery? Enzymatic and electrocardiographic evidence from the TEAM-2 study
    • Karagounis L, Sorensen SG, Menlove RL, TEAM-2 Investigators, et al. Does Thrombolysis In Myocardial Infarction (TIMi) perfusion grade 2 represent a mostly patent artery or a mostly occluded artery? Enzymatic and electrocardiographic evidence from the TEAM-2 study. J Am Coll Cardiol 1992; 19: 1-10
    • (1992) J Am Coll Cardiol , vol.19 , pp. 1-10
    • Karagounis, L.1    Sorensen, S.G.2    Menlove, R.L.3
  • 26
    • 0027182471 scopus 로고
    • Time course of left ventricular function and coronary patency after saruplase vs streptokinase in acute myocardial infarction
    • Schofer J, Lins M, Mathey DG, et al. Time course of left ventricular function and coronary patency after saruplase vs streptokinase in acute myocardial infarction. Eur Heart J 1993; 14: 958-63
    • (1993) Eur Heart J , vol.14 , pp. 958-963
    • Schofer, J.1    Lins, M.2    Mathey, D.G.3
  • 27
    • 0027172657 scopus 로고
    • TIMI perfusion grade 3 but not grade 2 results in improved outcome after thrombolysis for acute myocardial infarction: Ventriculographic, enzymatic, and electrocardiographic evidence from the TEAM-3 study
    • Anderson JL, Karanougis LA, Becker LC, TEAM-3 Investigators, et al. TIMI perfusion grade 3 but not grade 2 results in improved outcome after thrombolysis for acute myocardial infarction: ventriculographic, enzymatic, and electrocardiographic evidence from the TEAM-3 study. Circulation 1993; 87: 1829-39
    • (1993) Circulation , vol.87 , pp. 1829-1839
    • Anderson, J.L.1    Karanougis, L.A.2    Becker, L.C.3
  • 28
    • 7144250126 scopus 로고
    • Consequences of TIMI 2 vs 3 flow at 90 minutes following: Thrombolysis
    • Gibson CM, Cannon CP, Piana RN, TIM1-4 Study Group, et al. Consequences of TIMI 2 vs 3 flow at 90 minutes following: thrombolysis [abstract]. J Am Coll Cardiol 1993; 21 Suppl. A: 348A
    • (1993) J Am Coll Cardiol , vol.21 , Issue.SUPPL. A
    • Gibson, C.M.1    Cannon, C.P.2    Piana, R.N.3
  • 29
    • 0026537021 scopus 로고
    • Effect of early intravenous heparin on coronary patency, infarct size and bleeding complications after alteplase thrombolysis: Results of a randomized double blind European Cooperative Study Group trial
    • de Bono DP, Simoons ML, Tijssen J European Cooperative Study Group, et al. Effect of early intravenous heparin on coronary patency, infarct size and bleeding complications after alteplase thrombolysis: results of a randomized double blind European Cooperative Study Group trial. Br Heart J 1992; 67: 122-8
    • (1992) Br Heart J , vol.67 , pp. 122-128
    • De Bono, D.P.1    Simoons, M.L.2    Tijssen, J.3
  • 30
    • 0026607185 scopus 로고
    • A randomized comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction
    • ISIS-3. A randomized comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction. Lancet 1992; 339: 753-770
    • (1992) Lancet , vol.339 , pp. 753-770
  • 31
    • 0030847845 scopus 로고    scopus 로고
    • COBALT: A comparison of continuous infusion of alteplase with double-bolus administration for acute myocardial infarction
    • Continuous Infusion versus Double Bolus Administration of Alteplase Investigators. COBALT: a comparison of continuous infusion of alteplase with double-bolus administration for acute myocardial infarction. N Engl J Med 1997; 337: 1124-30
    • (1997) N Engl J Med , vol.337 , pp. 1124-1130


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