New combination of the old drugs for elderly patients with small-cell lung cancer: A phase II study of the PAVE regimen

Journal of Clinical Oncology

Volumn 16, Issue 5, 1998, Pages 1940-1947

  Westeel, Virginie ^a   Murray, Nevin ^a   Gelmon, Karen ^a   Shah, Amil ^a   Sheehan, Finbar ^a   McKenzie, Michael ^a   Wong, Frances ^a   Morris, James ^a   Grafton, Clive ^a   Tsang, Victor ^a   Goddard, Karen ^a   Murphy, Kevin ^a   Parsons, Christina ^a   Amy, Roger ^a   Page, Ruth ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; ETOPOSIDE; VINCRISTINE;

AGED; ARTICLE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; ESOPHAGITIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; ORAL DRUG ADMINISTRATION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0031803819     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.5.1940     Document Type: Article

References (20)

1. Ihde DC: Chemotherapy of lung cancer. N Engl J Med 327:1434-1441, 1992
2. Evans WK, Feld R, Murray N, et al: Superiority of alternating non-cross-resistant chemotherapy in extensive small-cell lung cancer. Ann Int Med 107:451-458, 1987
3. Feld R, Evans WK, Coy P, et al: Canadian multicenter randomized trial comparing sequential and alternating administration of two non-cross-resistant chemotherapy combinations in patients with limited small-cell carcinoma of the lung. J Clin Oncol 5:1401-1409, 1987
4. Murray N, Coy P, Pater JL, et al: Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. J Clin Oncol 11:336-344, 1993
5. Cohen HJ: Geriatric principles of treatment applied to medical oncology: An overview. Semin Oncol 22:1-2, 1995
6. Johnson DH: Treatment of the elderly patient with small-cell lung cancer. Chest 103:72S-74S, 1993
7. Medical Research Council Lung Cancer Working Party: Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer: A stopped multicentre randomised trial. Lancet 348:563-566, 1996
8. Souhami RL, Spiro SG, Rudd RM, et al: Five-day oral etoposide treatment for advanced small-cell lung cancer: Randomized comparison with intravenous chemotherapy. J Natl Cancer Inst 89:577-580, 1997
9. DeVita VT, Schein PS: The use of drugs in combination for the treatment of cancer: Rationale and results. N Engl J Med 288:998-1006, 1973
10. Messeih AA, Schweitzer JM, Lipton A, et al: Addition of etoposide to cyclophosphamide, doxorubicin, and vincristine for remission induction and survival in patients with small-cell lung cancer. Cancer Treat Rep 71:61-66, 1987
11. Jackson DV, Case LD, Zekan PJ, et al: Improvement of long-term survival in extensive small-cell lung cancer. J Clin Oncol 6:1161-1169, 1988
12. Jett JR, Everson L, Therneau TM, et al: Treatment of limited-stage small-cell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide: A randomized trial of the North Central Cancer Treatment Group. J Clin Oncol 8:33-38, 1990
13. Siu LL, Shepherd FA, Murray N, et al: The influence of age on the treatment of limited-stage small-cell lung cancer. J Clin Oncol 14:821-828, 1996
14. Hryniuk W, Levine MN: Analysis of dose-intensity for adjuvant chemotherapy trials in stage II breast cancer. J Clin Oncol 4:1162-1170, 1986
15. Hande KR, Krozely MG, Greco A, et al: Unavailability of low-dose oral etoposide. J Clin Oncol 11:374-377, 1993
16. Ihde DC, Mushine JL, Kramer BS, et al: Prospective randomized comparison of high-dbse and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer. J Clin Oncol 12:2022-2034, 1994
17. Urban T, Chastang C, Schuller MP, et al: Cyclophosphamide-doxorubicin-etoposide (CDE) vs cisplatin-CDE in small-cell lung cancer (SCLC). Proc Am Soc Clin Oncol 15:383, 1996 (abstr 1149)
18. Rowinsky EK, Gilbert MR, McGuire WP: Sequences of Taxol and cisplatin: A phase I and pharmacologic study. J Clin Oncol 9:1692-1703, 1991
19. Slevin ML, Clarck PI, Joel SP, et al: A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer. J Clin Oncol 7:1333-1340, 1989
20. Murray N, Coldman A: The relationship between thoracic irradiation timing and long-term survival in combined modality therapy of limited-stage small-cell lung cancer. Proc Am Soc Clin Oncol 14:360, 1995 (abstr 1099)