Kinetics of racemization of (+)- and (-)-diethylpropion: Studies in aqueous solution, with and without the addition of cyclodextrins, in organic solvents and in human plasma

Chirality

Volumn 10, Issue 4, 1998, Pages 307-315

  Mey, Boris ^a   Paulus, Hanns ^a   Lamparter, Erich ^b   Blaschke, Gottfried ^c  

^a Central Institute   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Configurational stability; Cyclodextrin derivatives; Ionic strength; Native cyclodextrins; pH; Phosphate buffer concentration; Plasma protein affinity; Temperature

Indexed keywords

AMFEPRAMONE; BUFFER; CYCLODEXTRIN; ORGANIC SOLVENT; OROSOMUCOID; PHOSPHATE; PLASMA PROTEIN; SILICON DIOXIDE;

AQUEOUS SOLUTION; ARTICLE; DRUG STABILITY; ENANTIOMER; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIC STRENGTH; KINETICS; PH; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; TEMPERATURE;

APPETITE DEPRESSANTS; BLOOD PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; DIETHYLPROPION; HUMANS; HYDROGEN-ION CONCENTRATION; PROTEIN BINDING; PROTEIN CONFORMATION; TEMPERATURE;

EID: 0031803596     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1998)10:4<307::AID-CHIR4>3.0.CO;2-4     Document Type: Article

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