메뉴 건너뛰기




Volumn 31, Issue 4, 1998, Pages 390-401

Biotransformation of several structurally related 2B compounds to reactive metabolites in the somatic w/w+ assay of Drosophila melanogaster

Author keywords

1,2 dichloroethane (DCE); 1,3 dichloropropane (DCP); 5 methyl, 2 thiouracil (5M2TU); 5 propyl, 2 thiouracil (5P2TU); 6 methyl, 2 thiouracil (6M2TU); Dichloromethane (DCM); Drosophila melanogaster; Insecticide resistant strains (IR); Insecticide susceptible strain (IS); Somatic w w+ assay; Styrene (STY); Styrene 7,8 oxide (SO)

Indexed keywords

1,2 DICHLOROETHANE; CYTOCHROME P450; DICHLOROMETHANE; STYRENE; STYRENE OXIDE; THIOURACIL; THIOURACIL DERIVATIVE;

EID: 0031803309     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1998)31:4<390::AID-EM12>3.0.CO;2-7     Document Type: Article
Times cited : (6)

References (41)
  • 2
    • 0023856614 scopus 로고
    • Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP
    • Ashby J. Tennant RW (1988): Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutat Res 204:17-115.
    • (1988) Mutat Res , vol.204 , pp. 17-115
    • Ashby, J.1    Tennant, R.W.2
  • 4
    • 0026667174 scopus 로고
    • Dichloromethane (methylene chloride): Metabolism to formaldehyde and formation of DNA-protein cross-links in B6C3F1 mice and syrian golden hamsters
    • Casanova M. Devo DF, Heck HD'A (1992): Dichloromethane (methylene chloride): Metabolism to formaldehyde and formation of DNA-protein cross-links in B6C3F1 mice and syrian golden hamsters. Toxicol Appl Pharmacol 114:162-165.
    • (1992) Toxicol Appl Pharmacol , vol.114 , pp. 162-165
    • Casanova, M.1    Devo, D.F.2    Heck, H.D'A.3
  • 5
    • 0026589453 scopus 로고
    • The induction of mitotic chromosome malsegregation in Aspergillus nidiilans. Quantitative structure activity relationships (QSAR) analysis with chlorinated aliphatic hydrocarbons
    • Crebelli R, Andreoli C, Carere A, Conti G. Conti L, Cotta Ramusino M, Benigni R (1992): The induction of mitotic chromosome malsegregation in Aspergillus nidiilans. Quantitative structure activity relationships (QSAR) analysis with chlorinated aliphatic hydrocarbons. Mutat Res 266:117-134.
    • (1992) Mutat Res , vol.266 , pp. 117-134
    • Crebelli, R.1    Andreoli, C.2    Carere, A.3    Conti, G.4    Conti, L.5    Cotta Ramusino, M.6    Benigni, R.7
  • 6
    • 0029880271 scopus 로고    scopus 로고
    • An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells
    • Doherty AT. Ellard S, Parry EM, Parry JM (1996): An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis 11:247-274.
    • (1996) Mutagenesis , vol.11 , pp. 247-274
    • Doherty, A.T.1    Ellard, S.2    Parry, E.M.3    Parry, J.M.4
  • 8
    • 0342678250 scopus 로고
    • On the reaction kinetics and mutagenic activity of methylating and β-halogenethylating gasoline additives
    • Ehrenberg L, Osterman-Golkar S, Singh D, Lundqvist U (1974): On the reaction kinetics and mutagenic activity of methylating and β-halogenethylating gasoline additives. Radiat Bot 15:185-194.
    • (1974) Radiat Bot , vol.15 , pp. 185-194
    • Ehrenberg, L.1    Osterman-Golkar, S.2    Singh, D.3    Lundqvist, U.4
  • 10
    • 0011954017 scopus 로고
    • Cytochrome P450 in insects
    • Schenkman JB, Greim H (eds): Heidelberg: Springer Verlag
    • Feyereisen R (1993): Cytochrome P450 in insects. In Schenkman JB, Greim H (eds): "Cytochrome P450." Heidelberg: Springer Verlag, pp 311 -324.
    • (1993) Cytochrome P450 , pp. 311-324
    • Feyereisen, R.1
  • 11
    • 0023751542 scopus 로고
    • Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative or inconclusive result
    • Frei H, Würgler FE (1988): Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative or inconclusive result. Mutat Res 230:297-308.
    • (1988) Mutat Res , vol.230 , pp. 297-308
    • Frei, H.1    Würgler, F.E.2
  • 13
    • 0026035519 scopus 로고
    • Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich FP. Kirn DH, Iwasaki M (1991): Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4:168-179.
    • (1991) Chem Res Toxicol , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kirn, D.H.2    Iwasaki, M.3
  • 14
    • 0006072915 scopus 로고
    • Cytochrome P450 in Drosophila melanogaster. Activity, genetic variation and regulation
    • PhD Thesis, Stockholm. Hällström I, Magnusson J, Ramel C (1982): Relation between the somatic toxicity of dimethylnitrosamine and a genetically determined variation in the level and induction of cytochrome P450 in Drosophila
    • Hällström I (1984): Cytochrome P450 in Drosophila melanogaster. Activity, genetic variation and regulation. PhD Thesis, Stockholm. Hällström I, Magnusson J, Ramel C (1982): Relation between the somatic toxicity of dimethylnitrosamine and a genetically determined variation in the level and induction of cytochrome P450 in Drosophila. Mutat Res 92:161-168.
    • (1984) Mutat Res , vol.92 , pp. 161-168
    • Hällström, I.1
  • 15
    • 0026598823 scopus 로고
    • Antioxidant activity of propylthiouracil
    • Hicks M, Wong LS, Day RO (1992): Antioxidant activity of propylthiouracil. Biochem Pharmacol 43:439-444.
    • (1992) Biochem Pharmacol , vol.43 , pp. 439-444
    • Hicks, M.1    Wong, L.S.2    Day, R.O.3
  • 18
    • 0027816259 scopus 로고
    • Effect of methylene chloride inhalation on replicative DNA synthesis in the lungs of female B6C3F1 mice
    • Kanno J, Foley JF, Kari F, Anderson MW, Maronpot RR (1993): Effect of methylene chloride inhalation on replicative DNA synthesis in the lungs of female B6C3F1 mice. Environ Health Persp 101:271-276.
    • (1993) Environ Health Persp , vol.101 , pp. 271-276
    • Kanno, J.1    Foley, J.F.2    Kari, F.3    Anderson, M.W.4    Maronpot, R.R.5
  • 19
    • 0025190253 scopus 로고
    • 1-adenyl]ethyl)glutathione from ethylenedibromide: Effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation
    • 1-adenyl]ethyl)glutathione from ethylenedibromide: Effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis 11:419-424.
    • (1990) Carcinogenesis , vol.11 , pp. 419-424
    • Kim, D.H.1    Guengerich, F.P.2
  • 20
    • 0018085060 scopus 로고
    • Metabolism of dihalomethanes to carbon monoxide. III. In vitro studies on the mechanism of reaction
    • Kubic VL, Anders MW (1975): Metabolism of dihalomethanes to carbon monoxide. III. In vitro studies on the mechanism of reaction. Biochem Pharmacol 27:2349-2355.
    • (1975) Biochem Pharmacol , vol.27 , pp. 2349-2355
    • Kubic, V.L.1    Anders, M.W.2
  • 21
    • 0028973219 scopus 로고
    • Effects of indomethacin and arachidonic acid on styrene and styrene-7,8-oxide
    • Lee SH, Norppa H (1995): Effects of indomethacin and arachidonic acid on styrene and styrene-7,8-oxide. Mutat Res 348:93-99.
    • (1995) Mutat Res , vol.348 , pp. 93-99
    • Lee, S.H.1    Norppa, H.2
  • 22
    • 0016593769 scopus 로고
    • Metabolism and toxicity of styrene
    • Liebman K (1975): Metabolism and toxicity of styrene. Environ Health Perspec 11:115-119.
    • (1975) Environ Health Perspec , vol.11 , pp. 115-119
    • Liebman, K.1
  • 24
    • 0028128915 scopus 로고
    • CYP2C11 and CYP2Bl are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively
    • Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Vainio H, AoyamaT(1994):CYP2C11 and CYP2Bl are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochem Pharmacol 48:637-642.
    • (1994) Biochem Pharmacol , vol.48 , pp. 637-642
    • Nakajima, T.1    Wang, R.S.2    Elovaara, E.3    Gonzalez, F.J.4    Gelboin, H.V.5    Vainio, H.6    Aoyama, T.7
  • 26
    • 0019164219 scopus 로고
    • Styrene and styrene oxide induce SCEs and are metabolised in human lymphocyte cultures
    • Norppa H, Sorsa M, Pfaffli P, Vainio H (1980): Styrene and styrene oxide induce SCEs and are metabolised in human lymphocyte cultures. Carcinogenesis 1:357-361.
    • (1980) Carcinogenesis , vol.1 , pp. 357-361
    • Norppa, H.1    Sorsa, M.2    Pfaffli, P.3    Vainio, H.4
  • 27
    • 0020606635 scopus 로고
    • Metabolic activation of styrene by erythrocytes detected as increased sister-chromatid exchanges in cultured human lymphocytes
    • Norppa H, Vainio H, Sorsa M (1983): Metabolic activation of styrene by erythrocytes detected as increased sister-chromatid exchanges in cultured human lymphocytes. Cancer Res 43:3579-3582.
    • (1983) Cancer Res , vol.43 , pp. 3579-3582
    • Norppa, H.1    Vainio, H.2    Sorsa, M.3
  • 28
    • 0019258605 scopus 로고
    • Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane
    • Rannug U (1980): Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane. Mutat Res 76:269-295.
    • (1980) Mutat Res , vol.76 , pp. 269-295
    • Rannug, U.1
  • 29
    • 0028132745 scopus 로고
    • Activity of aromatic amines in the eye somatic mutation assay of Drosophila melanogaster
    • Rodriguez-Arnaiz R, Hernandez AJ (1994a): Activity of aromatic amines in the eye somatic mutation assay of Drosophila melanogaster. Environ Mol Mutagen 24:75-79.
    • (1994) Environ Mol Mutagen , vol.24 , pp. 75-79
    • Rodriguez-Arnaiz, R.1    Hernandez, A.J.2
  • 30
    • 0028210029 scopus 로고
    • Metabolic activation of four drugs in the eye mitotic recombination test of Drosophila melanogaster: Differences in strain sensitivity and route of exposure
    • Rodriguez-Arnaiz R, Hernandez AJ (1994b): Metabolic activation of four drugs in the eye mitotic recombination test of Drosophila melanogaster: Differences in strain sensitivity and route of exposure. Mutat Res 305:157-163.
    • (1994) Mutat Res , vol.305 , pp. 157-163
    • Rodriguez-Arnaiz, R.1    Hernandez, A.J.2
  • 31
    • 0027134983 scopus 로고
    • Strong intraspecies variability in the metabolic conversion of six procarcinogens to somatic cell recombinagens in Drosophila
    • Rodriguez-Arnaiz R, Vogel EW, Szakmary A (1993): Strong intraspecies variability in the metabolic conversion of six procarcinogens to somatic cell recombinagens in Drosophila. Mutagenesis 8:543-551.
    • (1993) Mutagenesis , vol.8 , pp. 543-551
    • Rodriguez-Arnaiz, R.1    Vogel, E.W.2    Szakmary, A.3
  • 33
    • 0023019112 scopus 로고
    • The formation of styrene glutathione adducts catalyzed by prostaglandin H synthetase
    • Stock BH, Bend JR, Eling TE (1986a): The formation of styrene glutathione adducts catalyzed by prostaglandin H synthetase. J Biol Chem 261:5959-5964.
    • (1986) J Biol Chem , vol.261 , pp. 5959-5964
    • Stock, B.H.1    Bend, J.R.2    Eling, T.E.3
  • 34
    • 0023030046 scopus 로고
    • Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthetase and horseradish peroxidase
    • Stock BH, Schreiber J, Guenat C, Mason RP, Bend JR, Eling TE (1986b): Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthetase and horseradish peroxidase. J Biol Chem 261:15915-15922.
    • (1986) J Biol Chem , vol.261 , pp. 15915-15922
    • Stock, B.H.1    Schreiber, J.2    Guenat, C.3    Mason, R.P.4    Bend, J.R.5    Eling, T.E.6
  • 36
    • 0027534655 scopus 로고
    • Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination
    • Vogel EW, Nirvard MJM (1993): Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination. Mutagenesis 8:57-81.
    • (1993) Mutagenesis , vol.8 , pp. 57-81
    • Vogel, E.W.1    Nirvard, M.J.M.2
  • 37
    • 0023618056 scopus 로고
    • Mechanistic and methodological aspects of chemically-induced somatic mutation and recombination in Drosophila melanogaster
    • Vogel EW, Zijilstra JA (1987a): Mechanistic and methodological aspects of chemically-induced somatic mutation and recombination in Drosophila melanogaster. Mutat Res 182:243-264.
    • (1987) Mutat Res , vol.182 , pp. 243-264
    • Vogel, E.W.1    Zijilstra, J.A.2
  • 38
    • 0023630075 scopus 로고
    • Somatic cell mutagenesis in Drosophila melanogaster in comparison with genetic damage in early germcell stages
    • Vogel EW, Zijilstra JA (1987b): Somatic cell mutagenesis in Drosophila melanogaster in comparison with genetic damage in early germcell stages. Mutat Res 180:189-200.
    • (1987) Mutat Res , vol.180 , pp. 189-200
    • Vogel, E.W.1    Zijilstra, J.A.2
  • 39
    • 0026600681 scopus 로고
    • In vitro metabolism and bioactivation of 1,2,3-trichloropropane
    • Weber GL, Sipes IG (1992): In vitro metabolism and bioactivation of 1,2,3-trichloropropane. Toxicol Appl Pharmacol 113:152-158.
    • (1992) Toxicol Appl Pharmacol , vol.113 , pp. 152-158
    • Weber, G.L.1    Sipes, I.G.2
  • 40
    • 0022607863 scopus 로고
    • In vivo mutagenicity testing using somatic cells of Drosophila melanogaster
    • de Serres FJ (ed): New York: Plenum Press
    • Wurgler FE, Vogel EW (1986): In vivo mutagenicity testing using somatic cells of Drosophila melanogaster. In de Serres FJ (ed): "Chemical Mutagens: Principles and Methods for Their Detection." New York: Plenum Press, pp 1-72.
    • (1986) Chemical Mutagens: Principles and Methods for Their Detection , pp. 1-72
    • Wurgler, F.E.1    Vogel, E.W.2
  • 41
    • 0027218546 scopus 로고
    • Effects of different styrene metabolites on cytotoxicity, sister-chromatid exchanges and cell-cycle kinetics in human whole blood lymphocytes in vitro
    • Zhang XX, Chakrabarti S, Malick AM. Richer CL (1993): Effects of different styrene metabolites on cytotoxicity, sister-chromatid exchanges and cell-cycle kinetics in human whole blood lymphocytes in vitro. Mutat Res 302:213-1 18.
    • (1993) Mutat Res , vol.302 , pp. 213-1118
    • Zhang, X.X.1    Chakrabarti, S.2    Malick, A.M.3    Richer, C.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.