Modelling the macrophage invasion of turnours: Effects on growth and composition

IMA Journal of Mathemathics Applied in Medicine and Biology

Volumn 15, Issue 2, 1998, Pages 165-185

  Owen, Markus R ^a   Sherratt, Jonathan A ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Cancer; Cytolysis; Immunotherapy; Macrophage; Tumour composition

Indexed keywords

ARTICLE; CANCER IMMUNOTHERAPY; CANCER INVASION; CYTOLYSIS; IMMUNE RESPONSE; MACROPHAGE; MATHEMATICAL MODEL; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VASCULARIZATION;

CHEMOTAXIS; CYTOTOXICITY, IMMUNOLOGIC; LINEAR MODELS; MACROPHAGES; MODELS, BIOLOGICAL; NEOPLASMS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED;

BIFURCATION (MATHEMATICS); CYTOLOGY; ENDOTHELIAL CELLS; MACROPHAGES;

BLOOD SUPPLY; CANCER; CELL TYPES; CYTOLYSE; ENDOTHELIAL-CELLS; IMMUNOTHERAPY; MUTANT CELLS; NORMAL TISSUE; TISSUE CELLS; TUMOR COMPOSITION;

TUMORS;

EID: 0031802840     PISSN: 02650746     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. ADAM, J. A. 1993 The dynamics of growth-factor-modified immune response to cancer growth: One dimensional models. Math. Comp. Model. 17, 83-106.
2. ALBERT, A., FREEDMAN, M. & PERELSON, A. S. 1980 Tumors and the immune system: The effects of a tumor growth modulator. Math. Biosci. 50, 25-28.
3. ALLAVENA, P., GRANDI, M., INCALCI, M. D., GERI, O., GUILIANI, F. C. & MANTOVANI, A. 1987 Human tumor cell lines with pleiotropic drug resistance are effectively killed by interleukin-2 activated monocytes. Int. J. Cancer, 40, 104-107.
4. ALLAVENA, P., PECCATORI, F., MAGGIONI, D., SIRONI, M., COLOMBO, N., LISSONI, A., GALAZKA, A., MEIERS, W., MANGIONI, C. & MANTOVANI, A. 1990 Intraperitoneal recombinant γ-interferon in patients with recurrent ascitic ovarian carcinoma: Modulation of cytotoxicity and cytokine production in tumor-associated effectors and major histocompatibility antigen expression on tumor cells. Cancer Res. 50, 7318-7323.
5. ALVING, C. R. 1983 Delivery of liposome-encapsulated drugs to macrophages. Pharmacol. Ther. 22, 407-424.
6. ANDREESEN, R. 1993 Macrophage-directed tumour immunotherapy revisited - past and future of an old doctor's dilemma. Res. Immunol. 144, 291-294.
7. ANDREESEN, R., SCHEIBENBOGEN, C., BRUGGER, W., KRAUSE, S., MEERPOHL, H., LESER, H., ENGLER, H. & LÖHR, G. 1990 Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: A new approach to cancer immunotherapy. Cancer Res. 50, 7450-7456.
8. AZNAVOORIAN, S., STRACKE, M. L., KRUTSCH, H., SCHIFFMANN, E. & LIOTTA, L. A. 1990 Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumour cells. J. Cell. Biol. 110, 1427-1438.
9. BOTTAZZI, B., POLENTARUTTI, N., ACERO, R., BALSARI, A., BORASCHI, D., GHEZZI, P., SALMONA, M. & MANTOVANI, A. 1983 Regulation of the macrophage content of neoplasms by chemoattractants. Science, 220, 210-212.
10. BOTTAZZI, B., GHEZZI, P., TARABOLETTI, G., SALMONA, M., COLOMBO, N., BONNAZZI, C., MANGIONI, C. & MANTOVANI, A. 1985 Tumor-derived chemotactic factor(s) from human ovarian carcinoma: Evidence for a role in the regulation of macrophage content of neoplastic tissues. Int. J. Cancer. 36, 167-173.
11. BOTTAZZI, B., ERBA, E., NOBILI, N., FAZIOLI, F., RAMBALDI, A. & MANTOVANI, A. 1990 A paracrine circuit in the regulation of the proliferation of macrophages infiltrating murine sarcomas. J. Immunol. 144, 2409-2412.
12. BOTTAZZI, B., WALTER, S., GOVONI, D., COLOTTA, F. & MANTOVANI, A. 1992 Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J. Immunol. 148, 1280-1285.
13. CHAPLAIN, M. A. J. 1995 The mathematical modelling of tumor angiogenesis and invasion. Acta Biotheor. 43, 387-402.
14. COLOMBO, N., PECCATORI, F., PAGANIN, C., BINI, S., BRANDELY, M., MANGIONI, C., MANTOVANI, A. & ALLAVENA, P. 1992 Anti-tumor and immunomodulatory activity of intraperitoneal IFN-γ in ovarian carcinoma patients with minimal residual tumor after chemotherapy. Int. J. Cancer 51, 42-46.
15. DOEDEL, E. J., KELLER, H. B. & KERNÉVEZ, J. P. 1991 Numerical analysis and control of bifurcation problems part i: Bifurcations in finite dimensions. Int. J. Bifurcations and Chaos 1, 493-520.
16. DURAND, R. E. 1990 Multicell spheroids as a model for cell kinetic studies. Cell Tiss. Kinet. 23, 141-159.
17. ESGRO, J. J., WHITWORTH, P. & FIDLER, I. J. 1990 Macrophages as effectors of tumor immunity. Immunol. Allergy Clin. N. Am. 10, 705-729.
18. FEARON, E. R. & VOGELSTEIN, B. 1990 A genetic model for colorectal tumorigenesis. Cell 61, 759-767.
19. FIDLER, I. J. & KLEINERMAN, E. S. 1993 Therapy of cancer metastasis by systemic activation of macrophages: From the bench to the clinic. Res. Immunol. 144, 284-287.
20. FISHER, R. A. 1937 The wave of advance of advantageous genes. Ann. Eugenics 73, 353-369.
21. + monocytic cells in the tumor stroma. Int. J. Cancer 35, 199-205.
22. HAMILTON, T. A. & ADAMS, D. O. 1987 Mechanisms of macrophage-mediated tumor injury. In: Tumor Immunology - Mechanisms, Diagnosis, Therapy (W. den Otter & E. J. Ruitenberg, eds.), pp. 89-107. New York: Elsevier Science Publishers.
23. HIBBS, J. B. 1991 Synthesis of nitric-oxide from 1-arginine - a recently discovered pathway induced by cytokines with antitumor and antimicrobial activity. Res. Immunol. 142, 565-569.
24. HIERNAUX, J. R. & LEFEVER, R. 1988 Population dynamics of tumors attacked by immunocompetent killer cells. In: Theoretical Immunology, Vol. 2 (A. S. Perelson, ed.), pp. 19-36. Reading, MA: Addison Wesley.
25. HOFSTADER, F., KONUR, A., ANDREESEN, R. & KNUCHEL, R. 1995 In-vitro test systems. Urologe-ausgabe A 34, 212-214.
26. JONJIC, N., ALBERTI, S., BERNASCONI, S., PERI, G., JILEK, P., ANICHINI, A., PARMIANI, G. & MANTOVANI, A. 1992 Heterogeneous susceptibility of human-melanoma clones to monocyte cytotoxicity - role of ICAM-1 defined by antibody blocking and gene transfer. Eur. J. Immunol. 22, 2255-2260.
27. KAISER, H. E. 1989 Regression of neoplasms in man. In: Influence of the Host on Tumour Development (R. B. Herberman, ed.), pp. 20-26. Dordrecht: Kluwer.
28. KELLER, R. 1993 The macrophage response to infectious agents Mechanisms of macrophage activation and tumour cell killing. Res. Immunol. 144, 271-273.
29. KUZNETSOV, V. A., ZHIVOGLYADOV, V. P. & STEPANOVA, L. A. 1993 Kinetic approach and estimation of the parameters of cellular interaction between the immunity system and a tumor. Arch. Immunol. Ther. Exp. 41, 21-31.
30. LEWIS, C. E., LEEK, R., HARRIS, A. & MCGEE, J. O. D. 1995 Cytokine regulation of angiogenesis in breast cancer - the role of tumor-associated macrophages. J. Leukoc. Biol. 57, 747-751.
31. MACE, K. F., EHRKE, M. J., HORI, K., MACCUBBIN, D. L. & MIHICH, E. 1988 Role of tumor necrosis factor in macrophage activation and tumoricidal activity. Cancer Res. 48, 5427-5432.
32. MANTOVANI, A. 1989 Cytotoxic killing of tumour cells by monocytes. In: Human Monocytes (M. Zembala & C. L. Asherson, eds.), pp. 303-311. London: Academic Press.
33. MANTOVANI, A. 1990 Tumour-associated macrophages. Curr. Opin. Immunol. 2, 689-692.
34. MANTOVANI, A. 1993 Discussion 50th forum in immunology - Macrophages and cancer. Res. Immunol. 144, 296.
35. MANTOVANI, A., BOTTAZZI, B., COLOTTA, F., SOZZANI, S. & RUCO, L. 1992 The origin and function of tumor-associated macrophages. Immunol. Today, 13, 265-270.
36. OWEN, M. R. & SHERRATT, J. A. 1997 Pattern formation and spatiotemporal irregularity in a model for macrophage-tumour interactions. J. Theor. Biol. 189, 63-80.
37. PREHN, R. T. 1994 Stimulatory effects of immune reactions upon the growths of untransplanted tumors. Cancer Res. 54, 908-914.
38. ROSENBERG, S. A. 1990 The immunotherapy and gene therapy of cancer. J. Clin. Oncol. 10, 180-199.
39. ROSENBERG, S. A., LOTZE, M., MUUL, L., CHANG, A. & AVIS, F. 1987 Progress report on the treatment of 157 patients with advanced cancer using LAK cells and IL2 or IL2 alone. New Engl. J. Med. 316, 889-897.
40. ROSENBERG, S. A., PACKARD, B., AEBERSOLD, P., SOLOMON, D. & TOPALIAN, S. 1990 Use of tumor-infiltrating lymphocytes and IL2 in the immunotherapy of patients with metastatic melanoma. New Engl. J. Med. 319, 1676-1680.
41. SAMPSON-JOHANNES, A. & CARLINO, J. A. 1988 Enhancement of human monocyte tumoricidal activity by recombinant M-CSF. J. Immunol. 141, 3680-3686.
42. SCHNEEMANN, M., SCHOEDON, G., HOFER, S., BLAU, N., GUERRERO, L. & SCHAFFNER, A. 1993 Nitric-oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J. Infect. Dis. 167, 1358-1363.
43. SHERRATT, J. A. & MURRAY, J. D. 1990 Mathematical analysis of a basic model for epidermal wound-healing. J. Math. Biol. 29, 389-404.
44. SHERRATT, J. A. & NOWAK, M. A. 1992 Oncogenes, anti-oncogenes and the immune response to cancer: A mathematical model. Proc. R. Soc. Lond. B 248, 261-271.
45. STEVENSON, H. C., LACERNA, L. V. & SUGARBAKER, P. H. 1988 Ex vivo activation of killer monocytes and their application to the treatment of human cancer. J. Clin. Apheresis, 4, 118-121.
46. VAN DAMME, J., PROOST, P., LENAERTS, J. P. & OPDENAKKER, G. 1992 Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176, 59-65.
47. VIGNAUD, J. M., MARIE, B., KLEIN, N., PLENAT, F., PECH, M., BORRELLY, J., MARTINET, N., DUPREZ, A. & MARTINET, Y. 1994 The role of platelet-derived growth-factor production by tumor-associated macrophages in tumor stroma formation in lung-cancer. Cancer Res. 54, 5455-5463.
48. VOLPE, J. 1990 Genetic stability and instability in tumours. In: Molecular Basis of Cancer Genes (M. Sluyser, ed.), pp. 9-23. Chichester: Ellis Harwood.
49. VUKANOVIC, J. & ISAACS, J. T. 1995 Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Cancer Res. 55, 1499-1504.
50. WALTER, S., BOTTAZZI, B., GOVONI, D., COLOTTA, F. & MANTOVANI, A. 1991 Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE. Int. J. Cancer 49, 431-435.
51. WANG, J. M., COLELLA, S., ALLAVENA, P. & MANTOVANI, A. 1987 Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor. Immunology, 60, 439-444.
52. WANG, J. M., GRIFFIN, J. D. RAMBALDI, A., CHEN, Z. G. & MANTOVANI, A. 1988 Induction of monocyte migration by recombinant macrophage colony-stimulating factor. J. Immunol. 141, 575-579.
53. WEINBERG, R. A. 1989 Oncogenes, anti-oncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res. 49, 3713-3721.
54. WHELDON, T. E. 1975 Mitotic autoregulation of normal and abnormal cells Alternative mechanisms for the derangement of growth control. J. Theor. Biol. 53, 421-433.