Effect of the Na+-channel modulator BDF 9148 on Ca2+-sensitivity and force of contraction of hypertrophic myocardium from transgene rats harboring the mouse Renin gene (TG(mREN2)27)

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 5, 1998, Pages 532-539

  Zobel, Carsten ^a   Brixius, Klara ^a   Frank, Konrad ^a   Schwinger, Robert H G ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

BDF 9148; Diastolic tension; Force frequency relationship; Hypertrophic myocard; Skinned fibers; Transgenic rats

Indexed keywords

4 [3 (1 BENZHYDRYL 3 AZETIDINYLOXY) 2 HYDROXYPROPOXY] 1H INDOLE 2 CARBONITRILE; RENIN; SODIUM CHANNEL AFFECTING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; ENZYME ACTIVITY; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; INOTROPISM; MOUSE; NONHUMAN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SKINNED MUSCLE FIBER; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AZETIDINES; CARDIOMEGALY; CARDIOTONIC AGENTS; HISTOLOGICAL TECHNIQUES; MALE; MICE; MUSCLE FIBERS; MYOCARDIAL CONTRACTION; NA(+)-K(+)-EXCHANGING ATPASE; RATS; RATS, SPRAGUE-DAWLEY; RENIN; SODIUM CHANNELS;

EID: 0031801938     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005204     Document Type: Article

References (45)

1. Armah BI, Brückner R, Stenzel W (1990) A novel inotropic agent that transiently prolongs cardiac action potential duration. Naunyn Schmiedeberg's Arch Pharmacol 341:R50
2. Bachmann S, Peters J, Engler E, Ganten D, Mullins J (1992) Transgenic rats carrying the mouse renin gene - morphological characterization of a low-renin hypertension model. Kidney Int 41:24-36
3. Benforado JM (1958) Frequency-dependent pharmacological and physiological effects on the rat ventricle strip. J Pharmacol Exp Ther 122:86-100
4. Bers DM (1987) Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na. J Gen Physiol 90:479-504
5. Bers DM (1991) Species differences and the role of sodium-calcium exchange in cardiac muscle relaxation. Ann NY Acad Sci 639:375-385
6. Brooks WW, Bing OH, Litwin SE, Conrad CH, Morgan JP (1994) Effects of treppe and calcium on intracellular calcium and function in the failing heart from the spontaneously hypertensive rat. Hypertension 24:347-356
7. Buggisch D, Isenberg G, Ravens U, Scholtysik G (1985) The role of sodium channels in the effects of the cardiotonic compound DPI 201-106 on contractility and membrane potentials in isolated mammalian heart preparations. Eur J Pharmacol 118:303-311
8. Clough DL, Pamnani MB, Haddy FJ (1983) Decreased myocardial Na+-K+-ATPase activity in one-kidney, one-clip hypertensive rats. Am J Physiol 245:H244-H251
9. Cohen CJ, Fozzard HA, Sheu SS (1982) Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circ Res 50:651-662
10. Fabiato A, Fabiato F (1979) Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol Paris 75:463-505
11. Flesch M, Schwinger RHG, Schiffer F, Frank K, Südkamp M, Kuhn Regnier F, Arnold G, Böhm M (1996) Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation 94:992-1002
12. Forester GV, Mainwood GW (1974) Interval dependent inotropic effects in the rat myocardium and the effect of calcium. Pflügers Arch 352:189-196
13. Frampton JE, Harrison SM, Boyett MR, Orchard CH (1991) Ca2+ and Na+ in rat myocytes showing different force-frequency relationships. Am J Physiol 261:C739-C750
14. Hajjar RJ, Gwathmey JK, Briggs GM, Morgan JP (1988) Differential effect of DPI 201-106 on the sensitivity of the myofilaments to Ca2+ in intact and skinned trabeculae from control and myopathic human hearts. J Clin Invest 82:1578-1584
15. Heyliger CE, Takeo S, Dhalla NS (1985) Alterations in sarcolemmal Na+-Ca2+ exchange and ATP-dependent Ca2+-binding in hypertrophied heart. Can J Cardiol 1:328-339
16. Hoey A, Amos GJ, Ravens U (1994a) Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium. J Mol Cell Cardiol 26:985-994
17. Hoey A, Amos GJ, Wettwer E, Ravens U (1994b) Differential effects of BDF 9148 and DPI 201-106 on action potential and contractility in rat and guinea pig myocardium. J Cardiovasc Pharmacol 23:907-915
18. Hoffman BF, Kelly JJ Jr (1959) Effect of rate and rhythm on contraction of rat papillary muscle. Am J Physiol 197:1199-1204
19. Koch Weser J, Blinks JR (1963) The influence of the interval between beats on myocardial contractility. Pharmacol Rev 15:601-652
20. Kurtz TW, Montano M, Chan L, Kabra P (1989) Molecular evidence of genetic heterogeneity in Wistar-Kyoto rats: implications for research with the spontaneously hypertensive rat. Hypertension 13:188-192
21. Lee SW, Schwartz A, Adams RJ, Yamori Y, Whitmer K, Lane LK, Wallick ET (1983) Decrease in Na+,K+-ATPase activity and [3H]ouabain binding sites in sarcolemma prepared from hearts of spontaneously hypertensive rats. Hypertension 5:682-688
22. Lee MA, Böhm M, Paul M, Bader M, Ganten U, Ganten D (1996) Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27. Am J Physiol 270:E91-29
23. Limas CJ (1978) Calcium transport ATPase of cardiac sarcoplasmic reticulum in experimental hyperthyroidism. Am J Physiol 235:H745-H752
24. Limas CJ, Conn JN (1977) Defective calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats. Circ Res 40:I62-I69
25. Limas CJ, Spier SS, Kahlon J (1980) Enhanced calcium transport by sarcoplasmic reticulum in mild cardiac hypertrophy. J Mol Cell Cardiol 12:1103-1116
26. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193:265-275
27. Magyar CE, Wang J, Azuma KK, McDonough AA (1995) Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development. Am J Physiol 269:C675-C682
28. Malhotra A, Penpargkul S, Schaible T, Scheuer J (1981) Contractile proteins and sarcoplasmic reticulum in physiologic cardiac hypertrophy. Am J Physiol 241:H263-H267
29. Morano I, Arndt H, Gartner C, Ruegg JC (1988) Skinned fibers of human atrium and ventricle: myosin isoenzymes and contractility. Circ Res 62:632-639
30. Müller-Ehmsen J, Frank K, Brixius K, Schwinger RHG (1997) Increase in force of contraction by activation of the Na+/Ca(2+)-exchanger in human myocardium. Br J Clin Pharmacol 43:399-405
31. Mullins JJ, Peters J, Ganten D (1990) Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344:541-544
32. Penefsky ZJ, Buckley NM, Litwak RS (1972) Effect of temperature and calcium on force-frequency relationships in mammalian ventricular myocardium. Pflügers Arch 332:271-282
33. Pfeffer JM, Pfeffer MA, Mirsky I, Braunwald E (1982) Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci USA 79:3310-3314
34. Pfeffer MA, Pfeffer JM, Frohlich ED (1976) Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat Circ Res 38:423-429
35. Rascher W, Clough D, Ganten D (1982) Hypertensive mechanisms. Schattauer, Stuttgart, pp 775-801
36. Schoner W, Ilberg C, Kramer R, Seubert W (1967) On the mechanism of Na+-and K+-stimulated hydrolysis of adenosine triphosphate. 1. Purification and properties of a Na+-and K+-activated ATPase from ox brain. Eur J Biochem 1:334-343
37. Schwinger RHG, Böhm M, Mittmann C, La Rosee K, Erdmann E (1991) Evidence for a sustained effectiveness of sodium-channel activators in failing human myocardium. J Mol Cell Cardiol 23:461-471
38. Schwinger RHG, Böhm M, La Rosee K, Schmidt U, Schulz C, Erdmann E (1992) Na(+)-channel activators increase cardiac glycoside sensitivity in failing human myocardium. J Cardiovasc Pharmacol 19:554-561
39. Schwinger RHG, Böhm M, Koch A, Uhlmann R, Uberfuhr P, Kreuzer E, Reichart B, Erdmann E (1993a) Force-frequency-relation in human atrial and ventricular myocardium. Mol Cell Biochem 119:73-78
40. Schwinger RHG, Böhm M, Müller Ehmsen J, Uhlmann R, Schmidt U, Stablein A, Uberfuhr P, Kreuzer E, Reichart B, Eissner HJ (1993b) Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart. Circulation 88:2267-2276
41. Schwinger RHG, Böhm M, Koch A, Schmidt U, Morano I, Eissner HJ, Uberfuhr P, Reichart B, Erdmann E (1994) The failing human heart is unable to use the Frank-Starling mechanism. Circ Res 74:959-969
42. Studer R, Reinecke H, Vetter R, Holtz J, Drexler H (1997) Expression and function of the cardiac Na+/Ca2+ exchanger in postnatal development of the rat, in experimental-induced cardiac hypertrophy and in the failing human heart. Basic Res Cardiol 92 [Suppl 1]:53-58
43. Suko J (1973) The calcium pump of cardiac sarcoplasmic reticulum. Functional alterations at different levels of thyroid state in rabbits J Physiol Lond 228:563-582
44. Tepel M, Theilmeier G, Bachmann J, Barenbrock M, Spieker C, Ganten D, Rann KH, Zidek W (1994) Increased cytosolic sodium and reduced Na,K-ATPase activity in transgenic rats. Hypertension 23:1198-1202
45. Zarain Herzberg A, Yano K, Elimban V, Dhalla NS (1994) Cardiac sarcoplasmic reticulum Ca(2+)-ATPase expression in streptozotocin-induced diabetic rat heart. Biochem Biophys Res Commun 203:113-120