Validation of freeze-drying to visualize percutaneous 3H-estradiol transport: The influence of skin hydration on the efficacy of the method

Skin Pharmacology and Applied Skin Physiology

Volumn 11, Issue 1, 1998, Pages 11-22

  Neelissen, Jan A M ^a   Arth, Christoph ^b   Schrijvers, Ad H G J ^c   Junginger, Hans E ^d   Boddé, Harry E ^d  

^a ASTRAZENECA R AND D   (Sweden)

^b Schwarz Pharma AG   (Germany)

^c LEIDEN UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Autoradiography; Estradiol; Freeze drying; Human skin; Percutaneous drug delivery; Skin hydration

Indexed keywords

ESTRADIOL; OSMIUM TETRAOXIDE; RESIN;

ARTICLE; ARTIFACT; AUTORADIOGRAPHY; CONTROLLED STUDY; DERMATOME; DRUG DISTRIBUTION; ELECTRON MICROSCOPY; EMBEDDING; FEMALE; FREEZE DRYING; HORMONE TRANSPORT; HUMAN; HUMAN TISSUE; HYDRATION; PRIORITY JOURNAL; SKIN; STRATUM CORNEUM; TOPICAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION; VAPOR;

ARTIFACTS; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; BUFFERS; ESTRADIOL; FREEZE DRYING; HUMANS; REPRODUCIBILITY OF RESULTS; SKIN; SPECIMEN HANDLING; TRITIUM; WATER;

EID: 0031801651     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000029804     Document Type: Article

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