The mechanism of cleavage under basic conditions of succinyl-anchored oligonucleotides

Nucleosides and Nucleotides

Volumn 17, Issue 7, 1998, Pages 1177-1182

  Palom, Yolanda ^a   Grandas, Anna ^a   Pedroso, Enrique ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ARTICLE; CHEMICAL ANALYSIS; NUCLEOTIDE METABOLISM; STRUCTURE ANALYSIS;

EID: 0031801327     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808004230     Document Type: Article

References (17)

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3. a) Ma, Y.; Sonveaux, E. Nucleosides and Nucleotides 1987, 6, 491-493,
4. b) Ma, Y.; Sonveaux, E. Biopolymers 1989, 28, 965-973.
5. Brown, T.; Pritchard, C.E.; Turner, G.; Salisbury, S.A. J. Chem Soc. Chem Commun. 1989, 891-893.
6. Lehmann, C.; Xu, Y-Z.; Christodoulou, C.; Tan, Z-K.; Gait, M.J. Nucleic Acids Res. 1989, 17, 2379-2390.
7. Stengele, K-P.; Pfleiderer, W. Tetrahedron Lett. 1990, 31, 2549-2552.
8. Brown, T.; Brown, D.J.S. in "Oligonucleotides and Analogues: a Practical Approach", (ed. Eckstein, F.), pp. 1-24, Oxford University Press, 1991.
9. +.
10. Montserrat, F.X.; Grandas, A.; Eritja, R.; Pedroso, E. Tetrahedron 1994, 50, 2617-2622.
11. +).
12. 2O to 100% ACN in 20min, 1mL/min, λ=260nm. Retention times: 15.9min (1), 14.0min (2), 9.4min (3), 5.3min (4), 4.4min (5).
13. a) Clark, J.H. Chem. Rev. 1980, 80, 429-452,
14. b) Pless, J. J. Org. Chem. 1974, 39, 2644-2646.
15. Fernández-Forner, D.; Palom, Y.; Ikuta, S.; Pedroso, E.; Eritja, R. Nucleic Acids Res. 1990, 18, 5729-5734.
16. Robles, J.; Pedroso, E.; Grandas, A., unpublished results.
17. Abreviations used are as follows: DCC=N,N′-dicyclohexylcarbodiimide, DMT=4,4′-dimethoxytrityl, TEA=triethylamine, DMF=N,N-dimethylformamide, DBU=1,8-diazabicyclo[5.4.0]undec-7-ene, DCM=dichloromethane.