Distinction of recrudescences from new infections by PCR-RFLP analysis in a comparative trial of CGP 56 697 and chloroquine in Tanzanian children

Tropical Medicine and International Health

Volumn 3, Issue 6, 1998, Pages 490-497

  Irion, Andrea ^a   Felger, Ingrid ^a   Abdulla, Salim ^b   Smith, Tom ^a   Mull, Robert ^c   Tanner, Marcel ^a   Hatz, Christoph ^a   Beck, Hans Peter ^a  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b IFAKARA HEALTH INSTITUTE   (Tanzania)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Artemether; Benflumetol; Drug treatment; Malaria; Plasmodium falciparum; Polymerase chain reaction; Resistance

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; CHLOROQUINE;

CHILD HEALTH; DISEASE CONTROL; DRUG PRESCRIBING; MALARIA;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG MIXTURE; HUMAN; MALARIA FALCIPARUM; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; REINFECTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TANZANIA;

ACUTE DISEASE; ANIMALS; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG COMBINATIONS; FLUORENES; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECURRENCE; SESQUITERPENES; TANZANIA; TIME FACTORS; TREATMENT OUTCOME;

TANZANIA;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0031800628     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.1998.00253.x     Document Type: Article

References (31)

1. Academy of Military Medical Sciences (1993) Benflumetol registration dossier. Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences (AMMS), Beijing, PRC.
2. Arnold K, Hien TT, Chinh NT, Phu NK & Mai PP (1990) A randomised comparative study of artemisinin (Qinghaosu) suppositories and oral quinine in acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 499-502.
3. Beck HP, Felger I, Huber W et al. (1997) Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66. Journal of Infectious Diseases 175, 921-926.
4. Bunnag D, Viravan C, Looareesuwan S, Karbwang J & Harinasuta T (1991) Clinical trial of artesunate and artemether on multidrug resistant falciparum malaria in Thailand. South-East Asian Journal of Tropical Medicine and Public Health 22, 380-385.
5. Contamin H, Fandeur T, Bonnefoy S, Skouri F, Ntoumi F & Merecreau-Puijalon O (1995) PCR typing of field isolates of Plasmodium falciparum. Journal of Clinical Microbiology 33, 944-951.
6. Contamin H, Fandeur T, Rogier C et al. (1996) Different genetic characteristics of Plasmodium falciparum isolates collected during successive clinical malaria episodes in Senegalese children. American Journal of Tropical Medicine and Hygiene 54, 632-643.
7. Creasey A, Fenton B, Walker A et al. (1990) Genetic diversity of Plasmodium falciparum shows geographic variation. American Journal of Tropical Medicine and Hygiene 42, 403-413.
8. Felger I, Tavol L & Beck HP (1993) Plasmodium falciparum: A rapid technique for genotyping the merozoite surface protein 2. Experimental Parasitology 77, 372-375.
9. Felger I, Marshall VM, Reeder JC, Hunt JA, Mgone C & Beck HP (1997) Sequence diversity and evolution of the merozoite surface antigen 2 of Plasmodium falciparum. Journal of Molecule Evolution 45, 154-169.
10. Felger I, Tavul L, Kabintik S et al. (1994) Plasmodium falciparum: extensive polymorphism in mcrozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea. Experimental Parasitology 79, 106-116.
11. Foley M, Ranford-Cartwright LC & Babiker HA (1992) Rapid and simple method for isolating malaria DNA from fingerprick samples of blood. Molecular and Biochemical Parasitology 53, 241-244.
12. Hatz C, Abdulla S, Mull B et al. (1998) The efficacy and safety of CGIP 56 697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years. Tropical Medicine and International Health 3, 498-504.
13. Henry MC., Eggelte TA, Watson P, Docters van Leeuwen B, Bakker DA & Klurin J (1994) Response of childhood malaria to chloroquine and Fansidar in an area of intermediate chloroquine resistance in Cote døIvoire. Transaction of the Royal Society of Tropical Medicine and Hygiene 88, 610-615.
14. Klavman DL (1985) Qinghaosu (artemisinin). An antimalarial drug from China. Science 228, 1045-1055.
15. Koella JC, Hatz C, Mshinda H et al. (1990) In vitro resistance patterns of Plasmodium falciparum to chloroquine - a reflection of strain-specific immunity? Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 662-665.
16. Kyle DE & Webster HK (1996) Postantibiotic effect of Quinine and dihydroartemisinine on Plasmodium falciparum in vitro: implications tor a mechanism of recrudescence. XIVth International Congress on Tropical Medicine and Malaria, Nagasaki, Japan (abstract).
17. Liu G, Shen C & Jiao X (1995) Clinical studies of compound artemether tablets. Review of 100 cases of Plasmodium falciparum malaria in children. Ciba Geigy Ltd, Basle, Switzerland.
18. Nakazawa S, Kanbara H &: Aikawa M (1995) Plasmodium falciparum: recrudescence of parasites in culture. Experimental Parasitology 81, 556-563.
19. Ntoumi F, Contamin H, Rogier C, Bonnefoy S, Trape JF & Mercereau-Puijalon O (1995) Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections. American Journal of Tropical Medicine and Hygiene 52, 81-88.
20. Peters W (1996) Drug combination and the prevention of resistance. In Chemotherapy and drug resistance in malaria. Academic Press, London, pp. 1003-1035.
21. Price RN, Nosten F, Luxemburger C et al. (1996) Effects of artemisinin derivatives on malaria transmissibility. Lancet 347, 1654-1658.
22. Qinghaosu Antimalarial Coordinating Research Group (1979) Antimalarial studies on qinghaosu. Chinese Medical Journal 92, 811-816.
23. Robert F, Ntoumi F, Angel G et al. (1996) Extensive genetic diversity in Plasmodium falciparum isolates collected from patients with severe malaria in Dakar, Senegal. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 704-711.
24. Saiki RK, Gelfand DH, Stoffel S et al. (1988) Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.
25. Smith TA, Charlwood J, Kihonda S et al. (1993) Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Tropica 54, 55-72.
26. Smythe JA, Coppel RL, Day KP et al. (1991) Structural diversity in the Plasmodium falciparum merozoite surface antigen 2. Proceeding of the National Academy of Sciences of the United State of America 88, 1751-1755.
27. Snounou G, & Beck HP (1998) The use of PCR-genotyping in the assessment of recrudescence or reinfection after antimalarial drug treatment. Parasitology Today (in press).
28. Thomas AW, Carr DA, Carter JIVI & Lyon JA (1990) Sequence comparison of, allelic forms of the Plasmodium falciparum merozoite surface antigen MSA2. Molecular and Biochemistry and Parasitology 43, 211-220.
29. Wernsdorfer WH, Kilimali VAEB, Wernsdorter G & Landgraf B (1996) Sensitivity of Plasmodium falciparum to Bentlumetol: Development of an in vitro field test system and its application to measuring the activity of the enantiomers. XIVth International Congress on Tropical Medicine and Malaria, Nagasaki, Japan (abstract).
30. White NJ, Waller D, Crawley J et al. (1992) Comparison of artemether and chloroqinne for severe malaria in Gamhian children. Lancet 339, 317-321.
31. White NJ & Olliaro PL (1996) Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria. Parasitology Today 12, 399-401.