DNA packaging mutant: Repression of the vaccinia virus A32 gene results in noninfectious, DNA-deficient, spherical, enveloped particles

Journal of Virology

Volumn 72, Issue 7, 1998, Pages 5769-5780

  Cassetti, Maria Cristina ^a,c   Merchlinsky, Michael ^b   Wolffe, Elizabeth J ^a   Weisberg, Andrea S ^a   Moss, Bernard ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN A32; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; DNA PACKAGING; GENE EXPRESSION REGULATION; GENE REPRESSION; LETHAL MUTANT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; VACCINIA VIRUS; VIRUS ASSEMBLY; VIRUS INFECTIVITY; VIRUS MORPHOGENESIS; VIRUS PARTICLE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0031800615     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.7.5769-5780.1998     Document Type: Article

References (54)

1. Alexander, W. A., B. Moss, and T. R. Fuerst. 1992. Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressor. J. Virol. 66:2934-2942.
2. Baroudy, B. M., S. Venkatesan, and B. Moss. 1982. Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain. Cell 28:315-324.
3. Baroudy, B. M., S. Venkatesan, and B. Moss. 1982. Structure and replication of vaccinia virus telomeres. Cold Spring Harbor Symp. Quant. Biol. 47:723-729.
4. Broyles, S. S., L. Yuen, S. Shuman, and B. Moss. 1988. Purification of a factor required for transcription of vaccinia virus early genes. J. Biol. Chem. 263:10754-10760.
5. Carroll, M., and B. Moss. 1997. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology 238: 198-211.
6. Carroll, M. W., and B. Moss. 1995. E. coli β-glucuronidase (GUS) as a marker for recombinant vaccinia viruses. BioTechniques 19:352-355.
7. Cassetti, M. C., and B. Moss. 1996. Interaction of the 82-kDa subunit of the vaccinia virus early transcription factor heterodimer with the promoter core sequence directs downstream DNA binding of the 70-kDa subunit. Proc. Natl. Acad. Sci. USA 93:7540-7545.
8. Catalano, C. E., D. Cue, and M. Feiss. 1995. Virus DNA packaging: the strategy used by phage lambda. Mol. Microbiol. 16:1075-1086.
9. Condit, R. C., A. Motyczka, and G. Spizz. 1983. Isolation, characterization, and physical mapping of temperature-sensitive mutants of vaccinia virus. Virology 128:429-443.
10. Dales, S., V. Milovanovitch, B. G. T. Pogo, S. B. Weintraub, T. Huima, S. Wilton, and G. McFadden. 1978. Biogenesis of vaccinia: isolation of conditional lethal mutants and electron microscopic characterization of their phenotypically expressed defects. Virology 84:403-428.
11. Earl, P. L., N. Cooper, and B. Moss. 1991. Preparation of cell cultures and vaccinia virus stocks, p. 16.16.1-16.16.7. In F. M. Ausubel, R. Brent. R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. Greene Publishing Associates & Wiley Interscience, New York, N.Y.
12. Earl, P. L., and B. Moss. 1991. Generation of recombinant vaccinia viruses, p. 16.17.1-16.17.16. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. Greene Publishing Associates & Wiley Interscience, New York, N.Y.
13. Ericsson, M., S. Cudmore, S. Shuman, R. C. Condit, G. Griffiths, and J. K. Locker. 1995. Characterization of ts16, a temperature-sensitive mutant of vaccinia virus. J. Virol. 69:7072-7086.
14. Feng, J.-N., M. Russel, and P. Model. 1997. A permeabilized system that assembles filamentous bacteriophage. Proc. Natl. Acad. Sci. USA 94:4068-4073.
15. Fuerst, T. R., M. P. Fernandez, and B. Moss. 1989. Transfer of the inducible lac repressor/operator system from Escherichia coli to a vaccinia virus expression vector. Proc. Natl. Acad. Sci. USA 86:2549-2553.
16. Garon, C. F., E. Barbosa, and B. Moss. 1978. Visualization of an inverted terminal repetition in vaccinia virus DNA. Proc. Natl. Acad. Sci. USA 75: 4863-4867.
17. Geshelin, P., and K. I. Berns. 1974. Characterization and localization of the naturally occurring cross-links in vaccinia virus DNA. J. Mol. Biol. 88:785-796.
18. Gorbalenya, A. E., and E. V. Koonin. 1989. Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Res. 17:8413-8440.
19. Grimley, P. M., E. N. Rosenblum, S. J. Mims, and B. Moss. 1970. Interruption by rifampin of an early stage in vaccinia virus morphogenesis: accumulation of membranes which are precursors of virus envelopes. J. Virol. 6:519-533.
20. Hu, X., L. J. Carroll, E. J. Wolffe, and B. Moss. 1996. De novo synthesis of the early transcription factor 70-kDa subunit is required for morphogenesis of vaccinia virions. J. Virol. 70:7669-7677.
21. Johnson, G. P., S. J. Goebel, and E. Paoletti. 1993. An update on the vaccinia virus genome. Virology 196:381-401.
22. Kane, E. M., and S. Shuman. 1993. Vaccinia virus morphogenesis is blocked by a temperature-sensitive mutation in the 17 gene that encodes a virion component. J. Virol. 67:2689-2698.
23. Kao, S.-Y., E. Ressner, J. Kates, and W. R. Bauer. 1981. Purification and characterization of a superhelix binding protein from vaccinia virus. Virology 111:500-508.
24. Kao, S. Y., and W. R. Bauer. 1987. Biosynthesis and phosphorylation of vaccinia virus structural protein VP11. Virology 159:399-407.
25. Kates, J. R., and B. R. McAuslan. 1967. Poxvirus DNA-dependent RNA polymerase. Proc. Natl. Acad. Sci. USA 58:134-141.
26. Katz, E., and B. Moss. 1970. Formation of a vaccinia virus structural polypeptide from a higher molecular weight precursor: inhibition by rifampicin. Proc. Natl. Acad. Sci. USA 6:677-684.
27. Koonin, E. V., and T. G. Senkevich. 1992. Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other. J. Gen. Virol. 73:989-993.
28. Koonin, E. V., T. G. Senkevich, and V. I. Chernos. 1993. Gene A32 protein product of vaccinia virus may be an ATPase involved in viral DNA packaging as indicated by sequence comparisons with other putative viral ATPases. Virus Genes 7:89-94.
29. Ladin, B. F., M. L. Blankenship, and T. Ben-Porat. 1980. Replication of herpesvirus DNA. V. Maturation of concatemeric DNA of pseudorabies virus to genome length is related to capsid formation. J. Virol. 33:1151-1164.
30. Ladin, B. F., S. Ihara, H. Hampl, and T. Ben-Porat. 1982. Pathway of assembly of herpesvirus capsids: an analysis using DNA+ temperature-sensitive mutants of pseudorabies virus. Virology 116:544-561.
31. Leduc, E. H., and W. Bernhard. 1962. Electron microscopic study of mouse liver infected by ectromelia virus. J. Ultrastruct. Res. 6:466-488.
32. Lutz, P., and C. Kedinger. 1996. Properties of the adenovirus IVa2 gene product, an effector of late-phase-dependent activation of the major late promoter. J. Virol. 70:1396-1405.
33. Merchlinsky, M., and B. Moss. 1989. Resolution of vaccinia virus DNA concatemer junctions requires late gene expression. J. Virol. 63:1595-1603.
34. Morgan, C. 1976. The insertion of DNA into vaccinia virus. Science 193:591-592.
35. Morgan, C., S. A. Ellison, H. M. Rose, and D. H. Moore. 1955. Serial sections of vaccinia virus examined at one stage of development in the electron microscope. Exp. Cell Res. 9:572-578.
36. Moss, B. 1996. Poxviridae: the viruses and their replication, p. 2637-2671. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven Publishers, Philadelphia, Pa.
37. Moss, B., and E. N. Rosenblum. 1973. Protein cleavage and poxvirus morphogenesis: tryptic peptide analysis of core precursors accumulated by blocking assembly with rifampicin. J. Mol. Biol. 81:267-269.
38. Munyon, W. E., E. Paoletti, and J. T. Grace, Jr. 1967. RNA polymerase activity in purified infectious vaccinia virus. Proc. Natl. Acad. Sci. USA 58: 2280-2288.
39. Nagayama, A., B. G. T. Pogo, and S. Dales. 1970. Biogenesis of vaccinia: separation of early stages from maturation by means of rifampicin. Virology 40:1039-1051.
40. Persson, H., B. Mathisen, L. Philipson, and U. Pettersson. 1979. A maturation protein in adenovirus morphogenesis. Virology 93:198-208.
41. Rodriguez, J. F., and G. L. Smith. 1990. IPTG-dependent vaccinia virus: identification of a virus protein enabling virion envelopment by Golgi membrane and egress. Nucleic Acids Res. 18:5347-5351.
42. Russel, M. 1991. Filamentous phage assembly. Mol. Microbiol. 5:1607-1613.
43. Senkevich, T. G., J. J. Bugert, J. R. Sisler, E. V. Koonin, G. Darai, and B. Moss. 1996. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science 273:813-816.
44. Senkevich, T. G., E. V. Koonin, J. J. Bugert, G. Darai, and B. Moss. 1997. The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology 233:19-42.
45. Sodeik, B., S. Cudmore, M. Ericsson, M. Esteban, E. G. Niles, and G. Griffiths. 1995. Assembly of vaccinia virus: incorporation of p14 and p32 into the membrane of the intracellular mature virus. J. Virol. 69:3560-3574.
46. Sodeik, B., R. W. Doms, M. Ericsson, G. Hiller, C. E. Machamer, W. van't Hof, G. van Meer, B. Moss, and G. Griffiths. 1993. Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks. J. Cell Biol. 121:521-541.
47. Thompson, C. L., and R. C. Condit. 1986. Marker rescue mapping of vaccinia virus temperature-sensitive mutants using overlapping cosmid clones representing the entire virus genome. Virology 150:10-20.
48. Vanderplasschen, A., and G. L. Smith. 1997. A novel virus binding assay using confocal microscopy: demonstration that intracellular and extracellular vaccinia virions bind to different cellular receptors. J. Virol. 71:4032-4041.
49. Ward, G. A., C. K. Stover, B. Moss, and T. R. Fuerst. 1995. Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells. Proc. Natl. Acad. Sci. USA 92:6773-6777.
50. Wittek, R., A. Menna, K. Muller, D. Schumperli, P. G. Bosley, and R. Wyler. 1978. Inverted terminal repeats in rabbit poxvirus and vaccinia virus DNA. J. Virol. 28:171-181.
51. Wolffe, E. J., D. M. Moore, P. J. Peters, and B. Moss. 1996. Vaccinia virus A17L open reading frame encodes an essential component of nascent viral membranes that is required to initiate morphogenesis. J. Virol. 70:2797-2808.
52. Zhang, Y., B.-Y. Ahn, and B. Moss. 1994. Targeting of a multicomponent transcription apparatus into assembling vaccinia virus particles requires RAP94, an RNA polymerase-associated protein. J. Virol. 68:1360-1370.
53. Zhang, Y., and B. Moss. 1991. Inducer-dependent conditional-lethal mutant animal viruses. Proc. Natl. Acad. Sci. USA 88:1511-1515.
54. Zimmermann, J., and W. Hammerschmidt. 1995. Structure and role of the terminal repeats of Epstein-Barr virus in processing and packaging of virion DNA. J. Virol. 69:3147-3155.