Early cyclosporine monotherapy in liver transplantation: A 5-year follow-up of a prospective, randomized trial

Hepatology

Volumn 27, Issue 6, 1998, Pages 1524-1529

  Belli, Luca S ^a   De Carlis, Luciano ^a   Rondinara, Gianfranco ^a   Alberti, Alberto B ^a   Bellati, Giorgio ^a   De Gasperi, Andrea ^a   Forti, Domenico ^a   Ideo G ^a  

^a OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; METHYLPREDNISOLONE; PREDNISONE; THYMOCYTE ANTIBODY;

ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; CYCLOSPORINE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; PROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 0031798854     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270609     Document Type: Article

References (24)

1. Maiorca R, Cristinelli L, Brunori G, Setti G, Salemi B, De Nobili U, Mittempergher E Prospective controlled trial of steroid withdrawal after six month in renal transplant patients treated with cyclosporine. Transplant Proc 1988;20(Suppl 3):121-125.
2. Hricik DE, Almawy WY, Strom TB. Trends in the use of glucocorticoids in renal transplantation. Transplantation 1994;57:979-989.
3. Price GD, Olsen SL, Taylor DO, O'Connell JB, Bristow MR, Renlund DG. Corticosteroid free maintenance immunosuppression after heart transplantation: feasibility and beneficial effects. J Heart Lung Transplant 1992;11:403-414.
4. Keogh A, McDonald P, Harvison A, Richens D, Mundy J, Spratt P. Initial steroid free versus steroid based maintenance therapy and steroid withdrawal after heart transplantation: two views of the steroid question. J Heart Lung Transplant 1992;11:421.
5. Margarit C, Martinez-Ibanez V, Tormo R, Infante D, Iglesias H. Maintenance immuno-suppression without steroids in pediatric liver transplantation. Transplant Proc 1989;21:2230.
6. Padbury RT, Gunson BK, Dousset B, Hubscher SG, Buchels JA, Neuberger JM, Elias E, et al. Steroid withdrawal from long term immunosuppression in liver allograft recipients. Transplantation 1993;55:789-794.
7. Dunn SP, Falkenstein K, Lawrence JP, Meyers R, Vincour CD, Billmire DF, Weintraub WH, et al. Monotherapy with cyclosporin for chronic immunosuppression in pediatric liver transplantation. Transplantation 1994;57:544.
8. Fraser GM, Grammoustianos K, Reddy J, Rolles K, Davidson B, Burroughs AK. Long term immuno-suppression without corticosteroids after orthotopic liver transplantation: a positive therapeutic aim. Liver Transplant Surg 1996;2:411-417.
9. Stegall MD, Everson GT, Schroter G, Karrer F, Bilir B, Sternberg T, Sherstha R, et al. Prednisone withdrawal late after adult liver transplantation reduces diabetes, hypertension and hypercholesterolemia without causing graft loss. HEPATOLOGY 1997;25:173-177.
10. Belli LS, De Cadis L, Rondinara GF, Romani F, Alberti AB, Pirotta V, Sansalone CV, et al. Prospective randomized trial of steroid withdrawal in liver transplant patients: preliminary report. Transpl Int 1994;7(Suppl 1):88-90.
11. Romani F, Belli LS, De Carlis L, Rondinara GF, Alberti AB, Sansalone CV, Bellati G, et al. Cyclosporin monotherapy (after 3 months) in liver transplant patients: a prospective randomized trial. Transplant Proc 1994;26:2683-2685.
12. International Working party. Terminology for hepatic graft rejection. HEPATOLOGY 1995;22:648-654.
13. Ishack K, Baptista A, Blanchi L, Callea F, De Groole J, Gudat F, Denk H, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699.
14. Belli LS, De Carlis L, Rondinara GF, Alberti AB, Rossetti O, Zurleni F, Bellati G, et al. Sandimmun-Neoral in liver transplantation: a remarkable improvement in long-term immunosuppression. Transplant Proc 1994; 26:2983-2984.
15. McDiarmid SV, Farmer DA, Goldstein LI, Martin P, Vargas J, Tripton JR, Simmons F, et al. A randomized prospective trial of steroid withdrawal after liver transplantation. Transplantation 1995;60:1443-1450.
16. Klintmalm GBG, Nery JR, Husbergh BS, Gonwa TA, Tillery GW. Rejection in liver transplantation. HEPATOLOGY 1988;10:978.
17. Mor E, Gonwa TA, Husberg BS, Goldstein RM, Klintmalm GB. Late onset acute rejection in orthotopic liver transplantation; associated risk factors and outcome. Transplantation 1992;54:821.
18. Anand AC, Hubscher SG, Gunson BK, McMaster P, Neuberger JM. Timing, significance and prognosis of late acute liver allograft rejection. Transplantation 1995;60:1098-1103.
19. Lowes JR, Hubscher SG, Neuberger JM. Chronic rejection of liver allografts. Gastroenterol Clin North Am 1993;22:401.
20. Ramos H, Reyes J, Abu-Elmgad K, Zeevi A, Reinsomen N, Tzakis A, Demetris AJ, et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995;59:212.
21. Farges O, Saliba F, Farhamant H, Samuel D, Bismuth A, Reynes M, Bismuth H. Incidence of rejection and infection after liver transplantation as a function of the primary disease: possible influence of alcohol and polyclonal immunoglobulins. HEPATOLOGY 1996;23:240-248.
22. Levine GN, Keaney JF, Vita JA. Cholesterol reduction in cardiovascular disease. N Engl J Med 1995;332:512-522.
23. Jindal RM. Posttransplant diabetes mellitus - a review. Transplantation 1994;58:1289-1298.
24. O'Grady JG, Forbes A, Rolles K, Calne RY, Williams R. An analysis of cyclosporine efficacy and toxicity after transplantation. Transplantation 1988;45:785.