Sertraline, a selective serotonin reuptake inhibitor modulates extracellular noradrenaline in the rat frontal cortex

Journal of Psychopharmacology

Volumn 12, Issue 4, 1998, Pages 366-370

  Thomas, D Nigel ^a,b   Nutt, David J ^a   Holman, R Bruce ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Biometric Research Institute   (United States)

Author keywords

Antidepressants; Brain microdialysis; Noradrenaline; Serotonin; Sertraline; SSRIs

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; NORADRENALIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT;

EID: 0031797710     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119801200406     Document Type: Article

References (29)

1. Abercrombie E D, Keller R W, Zigmond M J (1988) Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behaviourial studies. Neuroscience 27: 897-904
2. Bench C J, Friston, K J (1992) The anatomy of melancholia - focal abnormalities of cerebral blood flow in major depression. Psychol Med 22: 607-615
3. Blandina P, Goldfarb J, Walcott J, Green J P (1991) Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. J Pharmac Exp Ther 256: 341-347
4. Bolden-Watson C, Richelson E (1993) Blockade by newly developed antidepressants of biogenic uptake into rat brain synaptosomes. Life Sci 52: 1023-1029
5. Byerley W F, McConnell E J, McCabe R T, Dawson T M, Hrosser B I, Wamsley J K (1987) Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex. Brain Res 421: 377-381
6. Cervo L, Grignaschi G, Rossi C, Samanin R (1991) Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test. Eur J Pharmac 196: 21-222
7. Charney D S, Heninger G R, Reinhard J F, Sternberg D E, Hafstead K M (1982) The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects. Psychopharmacology 77: 217-222
8. Coppen A (1967) The biochemistry of affective disorders. Br J Psychiat 113: 1237-1264
9. Devane C L (1992) Pharmacokinetics of the selective serotonin reuptake inhibitors. J Clin Psychiat 52: 13-20
10. Garratt J C, Crespi F, Mason R, Marsden C A (1991) Effects of idazoxan on dorsal raphé 5-hydroxytryptamine neuronal function. Eur J Pharmac 193: 87-93
11. Green A R (1990) The effects of antidepressant drugs on noradrenergic receptor mechanisms in the central nervous system. In Heal D J, Marsden C A (eds), The pharmacology of noradrenaline in the central nervous system. Oxford Medical Publication, Oxford, pp. 316-348
12. Hyttel J (1994) Pharmacological characterization of selective serotonin reuptake inhibitors. Int Clin Psychopharmac 9 (Suppl 1): 19-26
13. Koe B K, Weissman A, Welch W M, Browne R G (1983) Sertraline, IS,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4tetrahydro-1-napthylamine, a new uptake inhibitor with selectivity for serotonin. J Pharmac Exp Ther 226: 686-700
14. Koe B K, Koch S W, Lebel L A, Minor K W, Page M G (1987) Sertraline, a selective inhibitor of serotonin uptake induces subsensitivity of β-adrenoceptor system of rat brain. Eur J Pharmac 141: 187-194
15. Kostowki W, Samanin R, Bareggi S R, Marc V, Garattini S, Vaizelli L (1974) Biochemical aspects of the interactions between midbrain raphé and locus coeruleus in the rat. Brain Res 82: 178-182
16. 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography. Neuropsychopharmacology 8: 57-65
17. Leonard B E (1992) Pharmacological difference of serotonin reuptake inhibitors and possible clinical relevance. Drugs 43: 3-10
18. L'Heureux R, Dennis T, Curet O, Scatton B (1986) Measurement of endogenous noradrenaline release in the rat cerebral cortex in vivo by transcortical dialysis: effects of drugs affecting noradrenergic transmission. J Neurochem 46: 1794-1801
19. Nutt D J, Lalies M D, Lione L A, Hudson A L (1997) Noradrenergic mechanisms in the prefrontal cortex. J Psychopharmac 11: 163-168
20. Paxinos K C, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, New York
21. 1A receptor antagonist WAY 100135: an in vivo microdialysis study. Eur J Pharmac 239: 195-202
22. Schildkraut J J (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiat 122: 509-520
23. Siever L J (1987) Role of noradrenergic mechanisms in the aetiology of the affective disorders. In Meitzer H Y (ed.), Psychopharmacology: the third generation of progress. Raven Press, New York, pp. 493-504
24. Sulser F, Gillespie D D, Mishra R, Manier D H (1984) Desensitization by antidepressants of central norepinephrine receptor systems coupled to adenylate cyclase. Ann NY Acad Sci 430: 91-101
25. Thomas D N, Holman R B (1991a) A microdialysis study of the regulation of endogenous noradrenaline release in the rat hippocampus. J Neurochem 56: 1741-1746
26. Thomas DN, Holman RB (1991b) Regulation of endogenous noradrenaline release in rat hippocampus versus frontal cortex: in vivo microdialysis. Br J Pharmac 102: 5P
27. Thomas D N, Holman R B (1991c) Effects of acute and chronic electroconvulsive shock on noradrenaline release in rat hippocampus and frontal cortex. Br J Pharmac 106: 430-436
28. Thomas D N, Nutt D J, Holman R B (1994) Regionally specific changes in extracellular noradrenaline following chronic idazoxan as revealed by in vivo microdialysis. Eur J Pharmac 261: 53-57
29. Valentine R J, Curtis A L, Parris D G, Wehby R G (1990) Antidepressant actions on brain noradrenergic neurons. J Pharmac Exp Ther 253: 833-840