A high-performance liquid chromatographic method for the determination of nicardipine in plasma and its application to pharmacokinetics in humans

Biomedical Chromatography

Volumn 12, Issue 6, 1998, Pages 326-329

  Li, Ke ^a   Zhang, Xin ^a   Yuan, Yi Sheng ^a   Zhao, Fei Lang ^a  

^a JINLING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; HUMAN BODIES; HUMAN PLASMAS; INTERNAL STANDARDS; ITS APPLICATIONS; NICARDIPINE; NIMODIPINE; REVERSED-PHASE LIQUID CHROMATOGRAPHIC METHODS; SIMPLE++; STATIONARY PHASE;

PHARMACOKINETICS;

ACETONITRILE; BORIC ACID; BUTANOL; HEXANE; NICARDIPINE; NIMODIPINE;

ARTICLE; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

EID: 0031797049     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0801(199811/12)12:6<326::AID-BMC755>3.0.CO;2-M     Document Type: Article

References (9)

1. Eastwood, R. J., Galustian, C., Bhamra, R. K. and Holt, D. W. High-performance liquid chromatographic method for the measurement of nicardipine in plasma or serum. (1990). J. Chromatgr. Biomed. Appl. 530, 463.
2. Higuchi, S. and Shrobara, Y. Comparative pharmacokinetics of nicardipine hydrochloride, a new vasodilator in various species. (1980). Xenobiotica 10, 447.
3. Kobayashi, S. Simple method for the determination of nicardipine in plasma using high-performance liquid chromatography. (1987). J. Chromatgr. Biomed. Appl. 420, 439.
4. Marciniec, B. and Kujawa, E. Qualitative-quantitative GC-MS analysis of some dihydropyridine derivatives. (1995). Chem. Anal. 40, 511.
5. Obendorf, D. and Stubauer, G. Adsorptive stripping voltammetry of nicardipine at a HMDE: determination of trace levels nicardipine in blood and urine. (1995). J. Pharm. Biomed. Anal. 13, 1339.
6. Pradhan, S. M. and Tipnis, H. P. High-performance liquid chromatographic method for determination of nicardipine in plasma: evaluation of pharmacokinetic parameters in healthy humans. (1995). Indian Drugs 32, 33.
7. Visor, G. C., Bajka, E. and Benjamin, E. Intranasal delivery of nicardipine in the rat. (1986). J. Pharm. Sci. 75, 44.
8. Sorkin, E. M. and Clissold, S. P. Nicardipine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders. (1987). Drugs 33, 296.
9. Watari, N., Mizumura, J. and Higuchi, S. Simultaneous microdetermination of nicardipine and its pyridine metabolite in body fluids by capillary column gas chromatography with electroncapture detection. (1990). J. Chromatgr. Biomed. Appl. 530, 438.