Low rates of pregnancy termination for prenatally diagnosed klinefelter syndrome and other sex chromosome polysomies

American Journal of Medical Genetics

Volumn 80, Issue 4, 1998, Pages 330-334

  Meschede, Dieter ^a   Louwen, Frank ^a   Nippert, Irmgard ^a   Holzgreve, Wolfgang ^a,b   Miny, Peter ^a,c   Horst, Jürgen ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

47,XXX female; 47,XYY syndrome; Genetic counseling; Klinefelter syndrome; Pregnancy termination; Prenatal diagnosis

Indexed keywords

ABORTION; ADULT; ARTICLE; CULTURAL FACTOR; DECISION MAKING; FEMALE; GENETIC COUNSELING; GESTATIONAL AGE; HUMAN; KARYOTYPE 47,XXX; KARYOTYPE 47,XXY; KLINEFELTER SYNDROME; MAJOR CLINICAL STUDY; MALE; PRENATAL DIAGNOSIS; PRIORITY JOURNAL;

EID: 0031796916     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19981204)80:4<330::AID-AJMG6>3.0.CO;2-7     Document Type: Article

References (24)

1. Abramsky L, Chappie J (1997): 47.XXY (Klinefelter syndrome) and 47,XYY: Estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenatal Diagn 17:363-368.
2. Anonymous (1979): What is to be done with the XYY fetus? (Editorial) Br Med J 1979:1519-1520.
3. Bartels DM, LeRoy BS, McCarthy P, Caplan AL (1997): Nondirectiveness in genetic counseling: A survey of practitioners. Am J Med Genet 72:172-179.
4. Bender BG, Linden MG, Robinson A (1993): Neuropsychological impairment in 42 adolescents with sex chromosome abnormalities. Am J Med Genet (Neuropsychiatr Genet) 48:169-173.
5. Bernhardt BA (1997): Empirical evidence that genetic counseling is directive: Where do we go from here? Am J Hum Genet 60:17-20.
6. Clarke A (1991): Is non-directive genetic counseling possible? Lancet 338:998-1001.
7. Evans JA, Hamerton JL, Robinson A (eds) (1990): Children and Young Adults with Sex Chromosome Aneuploidy. "Birth Defects: Original Article Series." Vol 26(4). New York: Wiley-Liss.
8. Hall JG, Gilchrist DM (1990): Turner syndrome and its variants. Pediatr Clin N Am 37:1421-1440.
9. Holmes-Siedle M, Ryynanen M, Lindenbaum RH (1987): Parental decisions regarding termination of pregnancy following prenatal detection of sex chromosome abnormality. Prenatal Diagn 7:239-244.
10. Hook EB (1983): Chromosome abnormalities and spontaneous fetal death following amniocentesis: Further data and associations with maternal age. Am J Hum Genet 35:110-116.
11. Kessler S (1997): Psychological aspects of genetic counseling: XI. Nondirectiveness revisited. Am J Med Genet 72:164-171.
12. Michie S, Bron F, Bobrow M, Marteau TM (1997): Nondirectiveness in genetic counseling: An empirical study. Am J Hum Genet 60:40-47.
13. Nippert I, Horst J (1994): Die Anwendungsproblematik der pränatalen Diagnose aus Sicht von Beratenen und Beratern. Bonn: Büro für Technikfolgenabschätzung beim Deutschen Bundestag.
14. Nippert I, Nippert PR, Horst J, Schmidtke J (1997): Die medizinischgenetische Versorgung in Deutschland. Med Genetik 9:188-205.
15. Robinson A, Bender BG, Linden MG (1989): Decisions following the intrautérine diagnosis of sex chromosome aneuploidy. Am J Med Genet 34:552-554.
16. Robinson A, Bender BG, Linden MG (1990): Summary of clinical findings in children and young adults with sex chromosome anomalies. In Evans JA, Hamerton JL, Robinson A (eds): "Children and Young Adults with Sex Chromosome Aneuploidy." Birth Defects: Original Article Series Vol 26(4). New York: Wiley-Lis, pp. 225-228.
17. Robinson A, Bender BG, Linden MG (1992): Prenatal diagnosis of sex chromosome abnormalities. In Milunsky A (ed): "Genetic Disorders and the Fetus. Diagnosis, Prevention, and Treatment." Baltimore: Johns Hopkins University Press, pp. 211-239.
18. Rovet J, Netley C, Bailey J, Keenan M, Stewart D (1995): Intelligence and achievement in children with extra X aneuploidy: A longitudinal perspective. Am J Med Genet (Neuropsychiatr Genet) 60:356-363.
19. Tannenbaum HL, Perus TE, Arbeitel BE, Hsu LYF (1986): Analysis of decision to continue or terminate pregnancies diagnosed with sex chromosome abnormalities by severity of prognosis, socioeconomic level and sex of fetus. Am J Hum Genet 39(Suppl):A183.
20. Verp MS, Bombard AT, Simpson JL, Elias S (1988): Parental decision following prenatal diagnosis of fetal chromosome abnormality. Am J Med Genet 29:613-622.
21. Wertz DC (1995): Ethical views of European geneticists: Results of an international survey. Presentation at the 27th Annual Meeting of the European Society of Human Genetics, Berlin, May 24, 1995.
22. Med Genetik 2/1995:109.
23. WolffG, Jung C (1995): Nondirectiveness and genetic counselling. J Genet Counsel 4:3-26.
24. World Health Organization, Wertz DC, Fletcher JC, Berg K (1995): "Guidelines on Ethical Issues in Medical Genetics and the Provision of Genetic Services." Geneva: WHO.