Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers

British Journal of Pharmacology

Volumn 125, Issue 6, 1998, Pages 1375-1381

  Southan, Andrew P ^a   Robertson, Brian ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Dendrotoxins; Inhibitory synaptic transmission; Mouse cerebellum; Potassium channels; Scorpion toxins

Indexed keywords

BICUCULLINE; DENDROTOXIN; MARGATOXIN; NEUROTOXIN; POTASSIUM CHANNEL BLOCKING AGENT; SCORPION VENOM; SNAKE VENOM; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

EID: 0031796708     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702218     Document Type: Article

References (35)

1. ANDERSEN, P., ECCLES, J. & VOORHOEVE, P.E. (1963). Inhibitory synapses on somas of Purkinje cells in the cerebellum. Nature, 199, 655-656.
2. AUGUSTINE, G.J. (1990). Regulation of transmitter release at the squid giant synapse by presynaptic delayed rectifier potassium current. J. Physiol., 431, 343-364.
3. BARRETT, J.C. & HARVEY, A.L. (1979). Effects of the venom of the green mamba, Dendroaspis angusticeps on skeletal muscle and neuromuscular transmission. Br. J. Pharmacol., 67, 199-205.
4. + conductances with complementary functions in postsynaptic integration at a central auditory synapse. J. Neurosci., 15, 8011-8022.
5. CHANDY, K.G. & GUTMAN, G.A. (1995). Voltage-gated potassium channel genes. In: Handbook of Receptors and Channels. (ed). North, RA. pp 1-71. CRC Press Inc.
6. CHRISTIE, M.J., NORTH, R.A., OSBORNE, P.B., DOUGLASS, J. & ADELMAN, J.P. (1990). Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits. Neuron, 2, 405-411.
7. + channels in the nervous system: location and molecular properties unveiled with α-dendrotoxin and homologues. In Neurotoxins and Neurobiology. ed. Tipton, K.F. & Dajas, F. pp. 103-122. Chichester: Ellis Horwood Ltd.
8. ECCLES, J.C., ITO, M. & SZENTÁGOTHAI, J. (1967). The Cerebellum as a Neuronal Machine. Berlin: Heidelberg, New York: Springer-Verlag.
9. + channels from Leiurus quinquestriatus var. hebraeus venom. Biochem., 33, 6834-6839.
10. + channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol., 45, 1227-1234.
11. HARVEY, A. (1997). Recent studies on dendrotoxins and potassium ion channels. Gen. Pharmac., 28, 7-12.
12. HAUSSER, M. & CLARK, B.A. (1997). Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron, 19, 665-678.
13. HOCHNER, B., KLEIN, M., SCHACHNER, S. & KANDEL, E.R. (1986). Action potential duration and the modulation of transmitter release from the sensory neurons of Aplysia in presynaptic facilitation and behavioural sensitizations. Proc. Natl. Acad. Sci. U.S.A., 83, 8410-8414.
14. HOPKINS, W., MILLER, J.L. & MILJANICH, G.P. (1996). Voltage-gated potassium channel inhibitors. Curr. Pharm. Design. 2, 389-396.
15. KATZ, B. (1969). The Release of Neural Transmitter Substances, Liverpool University Press: Liverpool.
16. + channels. J. Biol. Chem., 272, 27577-27581.
17. LARRAMENDI, L.M. (1969). Analysis of synaptogenesis in the cerebellum of the mouse. In Neurobiology of Cerebellar Evolution and Development ed. Llinas, R., pp. 803-843. Chicago: American Medical Association.
18. LLANO, I. & GERSCHENFELD, H.M. (1993). Inhibitory synaptic currents in stellate cells of rat cerebellar slices. J. Physiol., 468, 177-200.
19. 2+ signals in basket cells from rat cerebellar slices. J. Physiol., 502, 509-519.
20. + channel containing the α-subunit Kv1.2 in the basket cell nerve terminals of rat cerebellum. Neuroscience, 57, 1039-1045.
21. + channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. Br. J. Pharmacol., 120, 1029-1034.
22. PALAY, S.L. & CHAN-PALAY, V. (1974). Cerebellar Cortex. Cytology and Organization. Berlin: Springer-Verlag.
23. RAMÓN Y CAJAL, S. (1911). Histology of the Nervous System of Man and Vertebrates. Trans. (1995). Swanson, N. & Swanson, L. Oxford University Press, Oxford and New York.
24. + channel α- and β-subunit polypeptides in rat brain. J. Neurosci., 15, 5360-5371.
25. + channel β subunits: expression and distribution of Kvβ1 and Kvβ2 in adult rat brain. J. Neurosci., 16, 4846-4860.
26. + channels: more than model behaviour. Trends Pharmac. Sci., 18, 474-483.
27. ROBERTSON, B., OWEN, D., STOW, J., BUTLER, C. & NEWLAND, C. (1996). Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. FEBS Letters, 383, 26-30.
28. + channel subunit in different neurons of rat brain. J. Neurosci., 14, 2408-2417.
29. SOUTHAN, A.P. & OWEN, D.G. (1997). The contrasting effects of dendrotoxins and other potassium channel blockers in the CA1 and dentate gyrus regions of rat hippocampal slices. Br. J. Pharmacol., 122, 335-343.
30. SOUTHAN, A.P. & ROBERTSON, B. (1998). Patch-clamp recordings from cerebellar basket cell bodies and their presynaptic terminals reveal an asymmetric distribution of voltage-gated potassium channels. J. Neurosci., 18, 948-955.
31. STUART, G. & HAUSSER, M. (1994). Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron. 13, 703-712.
32. STÜHMER, W., RUPPERSBERG, J. P., SCHROTER, K. H., SAKMANN, B., STOCKER, M., GIESE, K.P., PERSCHKE, A., BAUMANN, A., & PONGS, O. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J., 8, 3235-3244.
33. VINCENT, P., ARMSTRONG, C.M. & MARTY, A. (1992). Inhibitory synaptic currents in rat cerebellar cells: modulation by postsynaptic depolarization. J. Physiol., 456, 453-471.
34. VINCENT, P. & MARTY, A. (1996). Fluctuations of inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices. J. Physiol., 494, 183-199.
35. + channels in terminal and juxtaparanodal regions of neurons. Nature. 365, 75-79.