Antiviral activity of ganciclovir, 9-(1,3-dihydroxy-2-propoxymethyl) guanine against woodchuck hepatitis virus: Quantitative measurement of woodchuck hepatitis virus DNA using storage phosphor technology

Italian Journal of Gastroenterology and Hepatology

Volumn 30, Issue 5, 1998, Pages 510-516

  Zahm, F E ^a,b,c   Bonino, F ^a   Giuseppetti, R ^a   Rapicetta, M ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Gastroenterology and Hepatology   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Ganciclovir treatment; Quantification of viraemia; Storage phosphor technology; Woodchuck hepatitis virus infection

Indexed keywords

ALPHA INTERFERON; FAMCICLOVIR; GANCICLOVIR; LAMIVUDINE; NUCLEOSIDE ANALOG; PHOSPHORUS 32; THYMOSIN;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; AUTORADIOGRAPHY; CYTOMEGALOVIRUS INFECTION; DNA DETERMINATION; DNA VIRUS; DOT HYBRIDIZATION; HEPATITIS B VIRUS; HEPATITIS VIRUS; IMAGING; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; VIREMIA; VIRUS INFECTION; VIRUS REPLICATION; X RAY ANALYSIS;

EID: 0031796037     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22,707 men in Taiwan. Lancet 1981;2:1129-33.
2. Maddrey WC. Chronic viral hepatitis: Diagnosis and management. Hosp Pract 1994;29:117-32.
3. Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha interferon treatment in patients with hepatitis B e- Antigen positive chronic hepatitis B. Ann Intern Med 1993;! 19:312-23.
4. Thomas HC, Lok ASF, Carreno V, Pareil G, Tanno H, Ferez V. et al. Comparative study of three doses of interferon alfa-2a in chronic active hepatitis B. J Viral Hepatitis 1994;l:139-48.
5. Feray C, Samuel D, Gigou M, Paradis V, David MF, Lemonnier C. et al. An open trial of interferon alpha recombinant for hepatitis C after liver transplantation: Antiviral effects and risk of rejection. Hepatology 1995;22:1084-9.
6. Garcia G, Smith CI, Weissberg JI. Adenine arabinoside monophosphate (vidarabine phosphate) in combination with human leukocyte interferon in the treatment of chronic hepatitis B: a randomized, double-blinded, placebo-controlled trial. Ann Intern Med 1987:107:278-85.
7. Thomas HC, Scully LJ. Antiviral therapy in hepatitis B infection. Br Med Bull 1985;41:374-80.
8. Main J, Thomas HC. Treatment of chronic hepatitis B infection. Pharmacol Ther 1990;45:373-81.
9. Mutchnick MG, Appelman HD, Chung HT, Aragona E, Gupta TP, Cummings GD, et al. Thymosin treatment of chronic hepatitis B: A placebo controlled pilot trial. Hepatology 1991;14:409-15.
10. Main J, Brown JL, Howells C, Galassini R, Crossey M, Karayiannis P, et al. A double blind, placebo controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. J Viral Hep 1996;3:211-5.
11. Nevens F, Main J, Honkoo P, Lome Tyrrell D, Barber J, et al. Lamivudine therapy for chronic hepatitis B: A six months randomized dose-ranging study. Gastroenterology 1997;113:1258-63.
12. Gilson RJC, Chopra K, Murray-Lyon I, Newell A, Nelson M, Tedder RS et al. A placebo controlled phase I/II study of adefovir dipivoxil (Bis-Pom PMEA) in patients with chronic hepatitis B infection. Hepatology 1996;24:4:281.
13. Bloomer J, Chan R, Sherman M, Ingraham P, DeHertogh D and the-008 study group. A preliminary study of lobucavir for chronic hepatitis B. Hepatology 1997:26:4:428.
14. Brook MG, Me Donald JA, Karayiannis P, Caruso L, Foster G, Harris JRW, et al. Randomized controlled trial of interferon alfa 2A (rbe) (Roferon-A) for the treatment of chronic hepatitis B virus (HBV) infection: factors that influence response. Gut 1989;30:1116-22.
15. Thomson MH, Jeffries DJ. Ganciclovir therapy in iatrogenically immunosuppressed patients with cytomegalovirus disease. J Anitimicrob Chemother 1989;23:61-70.
16. Yokota T, Konno K, Chonan E, Mochizuki S, Kojima K, Shugeta S et al. Comparative activities of several nucleoside analogues against duck hepatitis B virus in vitro. Antimicrob Ag Chemother 1990;34:1326-30.
17. Luscombe C, Pedersen J, Bowden S, Locarnini S. Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy. Liver 1994;14:182-92.
18. Smee DF, Knight SS, Duke AE, Robinson WS, Matthews TR, Marion PL. Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl) guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion associated DNA polymerase. Antimicrob Ag Chemother 1985;27:277-9.
19. Galibert F, Chen TN, Mandart E. Nucleoside sequence of a cloned woodchuck hepatitis virus genome: Comparison with the hepatitis B virus sequence. J Virol 1982;41:5.1-65.
20. Ponzetto A, Cote PJ, Ford EC, Purcell RH, Gerin JL. Core antigen and antibody in woodchucks after infection with woodchuck hepatitis virus. J Virol 1984;52:70-6.
21. Popper H, Shih JWK, Gerin JL, Wong DC, Hoyer BH, London WT et al. Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologie with virologie observations. Hepatology 1981 ;1:91-8.
22. Snyder RL, Tyler G, Summers J. Chronic hepatitis and hepatocellular carcinoma associated with woodchuck hepatitis virus. AmJPathol 1982;107:422-5.
23. Ponzetto A, Fiume L, Forzani B, Song SY, Busi C, Mattioli A et al. Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viraemia at doses lower than do the unconjugated drugs. Hepatology 1991;4:16-24.
24. Fiume L, di Stefano G, Busi C, Mattioli A, Rapicetta M, Giuseppetti R, et al. Inhibition of woodchuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route. Hepatology 1995;22:1072-7.
25. Zahm FE, d'Urso N, Bonino F, Ponzetto A. Treatment of woodchuck hepatitis virus infection in vivo with 2′-3′-dideoxycytidine ddC and 2'-3'-dideoxycytidine monophosphate coupled to lactosaminated human serum albumin (L-HSA ddCMP). Liver 1996;16:88-93.
26. Butterworth LA, Prior SL, Buda PJ, Faoagali JL, Cooksley G. Comparison of four methods for quantitative measurement of hepatitis B viral DNA. J Hepatol 1996;24:686-91.
27. Johnston RF, Pickett SC, Barker DL. Autoradiography using storage phosphor technology. Electrophoresis 1990; 11:355-60.
28. Colloredo Melis G, Bellati G, Leandro G. Fluctuation in viraemia, aminotransferases and IgM antibody to hepatitis B core antigen in chronic hepatitis B patients with disease exacerbations. Liver 1994; 14:175-81.
29. Korba BA, Xie H, Wright KN, Hornbuckle WE, Gerin JL, Tennant BC, et al. Liver targeted antiviral nucleosides: enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo. Hepatology 1996:23:958-63.
30. Gish RG, Lau JYN, Brooks L, Fang JWS, Steady SL, Imperial JC, et al. Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients. Hepatology 1996;23:1-7.
31. Nowak MA, Bonhoeffer S, Hill AM, Boehme R, Thomas HC, McDade H. Viral dynamics in hepatitis B virus infection. Med Sciences 1996;93:4398-402.